| Literature DB >> 33190551 |
G López-Angulo1, V Miranda-Soto2, J A López-Valenzuela1, J Montes-Avila1, S P Díaz-Camacho3, J A Garzón-Tiznado1, F Delgado-Vargas1.
Abstract
Echeveria subrigida is native to Mexico and its methanol extract (ME) shows relevant biological activities for human health, including the α-glucosidase inhibitory (αGI) activity that suggests its antidiabetic potential. Fractionation of the ME based on the αGI activity (IC50 in µg/mL) showed that quercetin-3-O-β-glucoside (131.1), isorhamnetin-3-O-β-glucoside (166.4), and dimers to heptamers proanthocyanidins (9.6) were among the main responsible of αGI activity in the ME. The purified compounds showed better activity than acarbose (IC50 = 4426 µg/mL).Entities:
Keywords: alpha-glucosidase inhibition; Echeveria subrigida; flavonoids; proanthocyanidins; tannins
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Year: 2020 PMID： 33190551 DOI： 10.1080/14786419.2020.1844695
Source DB: PubMed Journal: Nat Prod Res ISSN： 1478-6419 Impact factor: 2.861