Donovan J Lott1, Tanja Taivassalo2, Claudia R Senesac1, Rebecca J Willcocks1, Ann M Harrington3, Kirsten Zilke4, Hilary Cunkle1, Catherine Powers1, Erika L Finanger5, William D Rooney6, Gihan I Tennekoon3, Krista Vandenborne1. 1. Department of Physical Therapy, University of Florida, College of Public Health & Health Professions, Gainesville, Florida, USA. 2. Department of Physiology and Functional Genomics, University of Florida, Gainesville, Florida, USA. 3. Department of Physical Therapy, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA. 4. Oregon Health & Science University, Shriners Hospitals for Children, Portland, Oregon, USA. 5. Department of Pediatrics, Oregon Health and Science University, Portland, Oregon, USA. 6. Advanced Imaging Research Center, Oregon Health and Science University, Portland, Oregon, USA.
Abstract
INTRODUCTION: In this study we explored walking activity in a large cohort of boys with Duchenne muscular dystrophy (DMD). METHODS: Step activity (monitored for 7 days), functional ability, and strength were quantified in ambulatory boys (5-12.9 years of age) with DMD and unaffected boys. Ambulatory status was determined 2 years later. RESULTS: Two to 5 days of activity monitoring predicted weekly step activity (adjusted R2 = 0.80-0.95). Age comparisons revealed significant declines for step activity with increasing age, and relationships were found between step activity with both function and strength (P < .01). Our regression model predicted 36.5% of the variance in step activity. Those who were still ambulatory after 2 years demonstrated baseline step activity nearly double that of those who were no longer walking 2 years later (P < .01). DISCUSSION: Step activity for DMD is related to and predictive of functional declines, which may be useful for clinical trials.
INTRODUCTION: In this study we explored walking activity in a large cohort of boys with Duchenne muscular dystrophy (DMD). METHODS: Step activity (monitored for 7 days), functional ability, and strength were quantified in ambulatory boys (5-12.9 years of age) with DMD and unaffected boys. Ambulatory status was determined 2 years later. RESULTS: Two to 5 days of activity monitoring predicted weekly step activity (adjusted R2 = 0.80-0.95). Age comparisons revealed significant declines for step activity with increasing age, and relationships were found between step activity with both function and strength (P < .01). Our regression model predicted 36.5% of the variance in step activity. Those who were still ambulatory after 2 years demonstrated baseline step activity nearly double that of those who were no longer walking 2 years later (P < .01). DISCUSSION: Step activity for DMD is related to and predictive of functional declines, which may be useful for clinical trials.
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Authors: Kavya S Nair; Donovan J Lott; Sean C Forbes; Alison M Barnard; Rebecca J Willcocks; Claudia R Senesac; Michael J Daniels; Ann T Harrington; Gihan I Tennekoon; Kirsten Zilke; Erika L Finanger; Richard S Finkel; William D Rooney; Glenn A Walter; Krista Vandenborne Journal: J Neuromuscul Dis Date: 2022