Berner Andrée Sandoval-Ramírez1, Úrsula Catalán2, Anna Pedret3, Rosa M Valls1, Ma José Motilva4, Laura Rubió5, Rosa Solà6. 1. Universitat Rovira i Virgili, Faculty of Medicine and Health Sciences, Medicine and Surgery Department, Functional Nutrition, Oxidation, CVD Research Group (NFOC-Salut), Reus, Catalonia, Spain. 2. Universitat Rovira i Virgili, Faculty of Medicine and Health Sciences, Medicine and Surgery Department, Functional Nutrition, Oxidation, CVD Research Group (NFOC-Salut), Reus, Catalonia, Spain; Eurecat, Centre Tecnològic de Catalunya, Unitat de Nutrició i Salut, Reus, Catalonia, Spain. Electronic address: ursula.catalan@eurecat.org. 3. Universitat Rovira i Virgili, Faculty of Medicine and Health Sciences, Medicine and Surgery Department, Functional Nutrition, Oxidation, CVD Research Group (NFOC-Salut), Reus, Catalonia, Spain; Eurecat, Centre Tecnològic de Catalunya, Unitat de Nutrició i Salut, Reus, Catalonia, Spain. 4. Instituto de Ciencias de la Vid y del Vino-ICVV (CSIC), Gobierno de La Rioja, Universidad de La Rioja, Logroño, La Rioja, Spain. 5. Food Technology Department, XaRTA-TPV, Agrotecnio Center, Escola Tecnica Superior d'Enginyeria Agraria, University of Lleida, Lleida, Catalonia, Spain. 6. Universitat Rovira i Virgili, Faculty of Medicine and Health Sciences, Medicine and Surgery Department, Functional Nutrition, Oxidation, CVD Research Group (NFOC-Salut), Reus, Catalonia, Spain; Eurecat, Centre Tecnològic de Catalunya, Unitat de Nutrició i Salut, Reus, Catalonia, Spain; Hospital Universitari Sant Joan de Reus (HUSJR), Reus, Catalonia, Spain.
Abstract
BACKGROUND & AIMS: The integrity of the intestinal barrier in the diseased is key to prevent further complications and disease such as sepsis and death, whereas, the role of food bioactive molecules (i. e. phenolic compounds (PCs) on the intestinal barrier, is still unknown. The current aim was to explore the benefits of the oral PC administration on the intestinal barrier integrity in animals. METHODS: The effects of PCs on the intestinal barrier integrity in in vivo animal models of intestinal inflammation were assessed up-to August 2020 from the PubMed, SCOPUS, and Cochrane Library databases under the PRISMA methodology. The risk of bias was assessed from ARRAY and SCYRCLE tools. RESULTS: From 1241 articles, 14 studies were included. In animals, oral resveratrol (n = 6) improves the intestinal barrier integrity and reduces intestinal damage. Additionally, grape seed extract (n = 2), curcumin (n = 1), genistein (n = 1), chlorogenic acid (n = 1), grape pomace (n = 1), olive leaf (n = 1) or cranberry extract (n = 1) improve the intestinal barrier integrity downregulating various inflammatory molecules (TNF-α, and other interleukins), and increasing the antioxidant enzymes in animals. Furthermore, resveratrol, quercetin, epigallocatechin, and other PCs improve the epithelial barrier integrity and pro-inflammatory molecule expression in the intestinal epithelia. CONCLUSIONS: The oral PC administration in animals improves the intestinal barrier integrity and function from three main mechanisms: 1) The reduction of pro-inflammatory molecules, 2) the improvement in tight-junction protein expression, and 3) the improvement of the antioxidant intracellular activity suggesting the potential use of PCs in the management of intestinal injury in humans, particularly for resveratrol, the most studied PC.
BACKGROUND & AIMS: The integrity of the intestinal barrier in the diseased is key to prevent further complications and disease such as sepsis and death, whereas, the role of food bioactive molecules (i. e. phenolic compounds (PCs) on the intestinal barrier, is still unknown. The current aim was to explore the benefits of the oral PC administration on the intestinal barrier integrity in animals. METHODS: The effects of PCs on the intestinal barrier integrity in in vivo animal models of intestinal inflammation were assessed up-to August 2020 from the PubMed, SCOPUS, and Cochrane Library databases under the PRISMA methodology. The risk of bias was assessed from ARRAY and SCYRCLE tools. RESULTS: From 1241 articles, 14 studies were included. In animals, oral resveratrol (n = 6) improves the intestinal barrier integrity and reduces intestinal damage. Additionally, grape seed extract (n = 2), curcumin (n = 1), genistein (n = 1), chlorogenic acid (n = 1), grape pomace (n = 1), olive leaf (n = 1) or cranberry extract (n = 1) improve the intestinal barrier integrity downregulating various inflammatory molecules (TNF-α, and other interleukins), and increasing the antioxidant enzymes in animals. Furthermore, resveratrol, quercetin, epigallocatechin, and other PCs improve the epithelial barrier integrity and pro-inflammatory molecule expression in the intestinal epithelia. CONCLUSIONS: The oral PC administration in animals improves the intestinal barrier integrity and function from three main mechanisms: 1) The reduction of pro-inflammatory molecules, 2) the improvement in tight-junction protein expression, and 3) the improvement of the antioxidant intracellular activity suggesting the potential use of PCs in the management of intestinal injury in humans, particularly for resveratrol, the most studied PC.
Authors: Antonio Jesús Ruiz-Malagón; María José Rodríguez-Sanchez; María Jesús Rodríguez-Sojo; Teresa Vezza; Ivo Pischel; Francesca Algieri; María Elena Rodríguez-Cabezas; Alba Rodríguez-Nogales; Julio Gálvez Journal: Front Pharmacol Date: 2022-09-02 Impact factor: 5.988