Eric Xie1, Maya M Lapinski2, Sarah Talamantes3, Bareng A S Nonyane4, Maria Cristina Figueroa Magalhães5, Kala Visvanathan1,6, Antonio C Wolff1, Cesar A Santa-Maria7. 1. Johns Hopkins Sidney Kimmel Comprehensive Cancer Center, 201 North Broadway, Rm 10262, Baltimore, MD, 21287, USA. 2. Johns Hopkins University Department of Biomedical Engineering, Baltimore, MD, USA. 3. Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Chicago, IL, USA. 4. Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA. 5. Pontifícia Universidade Católica Do Paraná, Curitiba, Brazil. 6. Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA. 7. Johns Hopkins Sidney Kimmel Comprehensive Cancer Center, 201 North Broadway, Rm 10262, Baltimore, MD, 21287, USA. csantam2@jhmi.edu.
Abstract
PURPOSE: To evaluate the relationship of circulating immune cells with recurrence and metabolic/lifestyle factors in patients with early-stage breast cancer. METHODS: Patients with early-stage breast cancer were identified from the electronic record and institutional registry. Lymphocyte and monocyte counts were obtained from blood samples at time of diagnosis prior to any chemotherapy. Correlations between lymphocyte and monocyte and recurrence were assessed in the entire cohort and among obese patients, those reporting alcohol consumption and smoking. Competing risk regression was used to analyze time to recurrence. RESULTS: A total of 950 patients with ≥ 5 years of follow-up were identified; 433 had complete data and were eligible for analysis. 293 (68%) had hormone receptor-positive breast cancer, 82 (19%) HER2 positive, and 53 (13%) triple negative. Patients in the highest quintile of lymphocytes compared to the lowest quintile had lower risk of recurrence (subhazard ratio (SHR) = 0.17, 95% CI [0.03-0.93], p = 0.041) while patients in the highest quintile of monocytes had lower risk for recurrence (SHR = 0.19, 95% CI [0.04, 0.92], p = 0.039). Higher monocytes were more strongly associated with lower recurrence among those reporting alcohol consumption (HR = 0.10, 95% CI [0.01, 0.91], p = 0.04). In obese patients, higher lymphocytes were associated with lower risk of recurrence (p = 0.046); in non-obese patients, higher monocytes were associated with lower risk of recurrence (p = 0.02). There were no correlations among patients who reported tobacco use. CONCLUSIONS: High lymphocyte and monocyte counts are associated with lower recurrence rate in early-stage breast cancer, particularly in obese patients and those reporting alcohol consumption.
PURPOSE: To evaluate the relationship of circulating immune cells with recurrence and metabolic/lifestyle factors in patients with early-stage breast cancer. METHODS: Patients with early-stage breast cancer were identified from the electronic record and institutional registry. Lymphocyte and monocyte counts were obtained from blood samples at time of diagnosis prior to any chemotherapy. Correlations between lymphocyte and monocyte and recurrence were assessed in the entire cohort and among obese patients, those reporting alcohol consumption and smoking. Competing risk regression was used to analyze time to recurrence. RESULTS: A total of 950 patients with ≥ 5 years of follow-up were identified; 433 had complete data and were eligible for analysis. 293 (68%) had hormone receptor-positive breast cancer, 82 (19%) HER2 positive, and 53 (13%) triple negative. Patients in the highest quintile of lymphocytes compared to the lowest quintile had lower risk of recurrence (subhazard ratio (SHR) = 0.17, 95% CI [0.03-0.93], p = 0.041) while patients in the highest quintile of monocytes had lower risk for recurrence (SHR = 0.19, 95% CI [0.04, 0.92], p = 0.039). Higher monocytes were more strongly associated with lower recurrence among those reporting alcohol consumption (HR = 0.10, 95% CI [0.01, 0.91], p = 0.04). In obese patients, higher lymphocytes were associated with lower risk of recurrence (p = 0.046); in non-obese patients, higher monocytes were associated with lower risk of recurrence (p = 0.02). There were no correlations among patients who reported tobacco use. CONCLUSIONS: High lymphocyte and monocyte counts are associated with lower recurrence rate in early-stage breast cancer, particularly in obese patients and those reporting alcohol consumption.
Entities:
Keywords:
Breast cancer; Circulating immune cells; Lymphocytes; Monocytes; Recurrence
Authors: Jennifer Y Sheng; Dipali Sharma; Gerald Jerome; Cesar Augusto Santa-Maria Journal: Oncology (Williston Park) Date: 2018-08-15 Impact factor: 2.533
Authors: Anosheh Afghahi; Natasha Purington; Summer S Han; Manisha Desai; Emma Pierson; Maya B Mathur; Tina Seto; Caroline A Thompson; Joseph Rigdon; Melinda L Telli; Sunil S Badve; Christina N Curtis; Robert B West; Kathleen Horst; Scarlett L Gomez; James M Ford; George W Sledge; Allison W Kurian Journal: Clin Cancer Res Date: 2018-03-26 Impact factor: 13.801