Time for Novel Strategies to Mitigate Cardiometabolic Risk in Shift Workers.

Circadian disruption induced by shift work is robustly associated with obesity, diabetes, and cardiovascular disease in humans. Less well-known are the mechanisms underlying these associations, and the effectiveness of strategies to reduce cardiometabolic risk in the shift work population. In this review, the different ways in which shift work can deteriorate cardiometabolic health, and how to use this information to reflect on various risk-mitigating strategies, is discussed. While individual strategies appear promising in animal studies, the multifactorial disease risk in shift workers likely requires a multidisciplinary approach. Therefore, the need for individually-tailored combined lifestyle interventions, that could be essential in reducing cardiometabolic disorders in the large population of shift workers in our 24/7 society, is argued.