| Literature DB >> 33183613 |
Yuda Liu1, Dongmei Chen2, Aoxue Zhang1, Man Xiao3, Zhenxia Li4, Wanhe Luo4, Yuanhu Pan4, Wei Qu4, Shuyu Xie5.
Abstract
In order to overcome treatment difficulty of S. aureus infections, a pH/hyaluronidase dual responsive enrofloxacin-cyclodextrin (β-CD) inclusion complexes (IC) containing hyaluronic acid/chitosan (HA/CS) self-assemble composite nanosystems covered by poloxamer 188 (F68) was firstly explored for targeted "on-demand" delivery. The FTIR, DSC and PXRD showed that enrofloxacin was embedded into IC and then distributed into F68 coating nanogels formulated by electrostatic interaction between CS and HA. The optimal nanosystems of 118.8 ± 30.7 nm showed excellent stability and responsive release in the acid medium, hyaluronidase containing medium, and LB broth medium where S. aureus present. The nanosystems displayed strong surface adsorption on S. aureus and enhanced activity against S. aureus. It had stronger sustained release than the polymeric nanoparticles formulated by entrapping of IC into F68 and the single HA/CS nanogels. This study provides a promising multi-functionalized nanosystems to overcome the treatment challenge of S. aureus and other bacterial infections.Entities:
Keywords: Hyaluronic acid/chitosan nanogels; Hyaluronidase responsiveness; Inclusion complexes; Staphylococcus aureus; pH responsiveness
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Year: 2020 PMID： 33183613 DOI： 10.1016/j.carbpol.2020.117162
Source DB: PubMed Journal: Carbohydr Polym ISSN： 0144-8617 Impact factor: 9.381