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Literature DB >> 3318272

Erythropoietin in capillary hemangioblastoma. An immunohistochemical study.

T Böhling¹, M Haltia, K Rosenlöf, F Fyhrquist.

Abstract

Capillary hemangioblastoma is a tumor known to be associated with secondary polycythemia. Therefore, specimens from ten hemangioblastomas were studied by immunohistochemistry for the presence of erythropoietin, renin substrate, and for various endothelial, histiocytic and glial markers. In all tumors scattered cells among the stromal cells showed a positive-staining reaction with both anti-erythropoietin and anti-renin substrate. The same cells also stained positively for alpha-1-anti-trypsin. It is concluded that, in addition to the capillary endothelial cells, pericytes and stromal cells, capillary hemangioblastomas harbor cells containing and perhaps producing renin substrate and/or erythropoietin or a substance with similar antigenic determinants.

Entities: Disease Gene

Mesh：

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Year: 1987 PMID： 3318272 DOI： 10.1007/BF00687208

Source DB: PubMed Journal: Acta Neuropathol ISSN： 0001-6322 Impact factor: 17.088

22 in total

1. HEMATOPOIETIC STIMULATING EFFECT OF A CEREBELLAR HEMANGIOBLASTOMA.

Authors: G J RACE; J W FINNEY; J T MALLAMS; G A BALLA
Journal: JAMA Date: 1964-01-11 Impact factor: 56.272

2. The association of polycythemia with a cerebellar hemangioblastoma. The production of an erythropoiesis stimulating factor by the tumor.

Authors: T A WALDMANN; E H LEVIN; M BALDWIN
Journal: Am J Med Date: 1961-08 Impact factor: 4.965

3. The cerebellar hemangioblastomas; review of fifty-three cases with special reference to cerebellar cysts and the association of polycythemia.

Authors: F CRAMER; M W KIMSEY
Journal: AMA Arch Neurol Psychiatry Date: 1952-02

10. A radioimmunoassay for erythropoietin: serum levels in normal human subjects and patients with hemopoietic disorders.

Authors: A B Rege; J Brookins; J W Fisher
Journal: J Lab Clin Med Date: 1982-12

2 in total

1. Histogenesis of stromal cells in cerebellar hemangioblastomas. An immunohistochemical study.

Authors: I Becker; W Paulus; W Roggendorf
Journal: Am J Pathol Date: 1989-02 Impact factor: 4.307

2. Vascular growth factors and receptors in capillary hemangioblastomas and hemangiopericytomas.

Authors: E Hatva; T Böhling; J Jääskeläinen; M G Persico; M Haltia; K Alitalo
Journal: Am J Pathol Date: 1996-03 Impact factor: 4.307

2 in total

Erythropoietin in capillary hemangioblastoma. An immunohistochemical study.

1. HEMATOPOIETIC STIMULATING EFFECT OF A CEREBELLAR HEMANGIOBLASTOMA.

2. The association of polycythemia with a cerebellar hemangioblastoma. The production of an erythropoiesis stimulating factor by the tumor.

3. The cerebellar hemangioblastomas; review of fifty-three cases with special reference to cerebellar cysts and the association of polycythemia.

4. [Ultrastructure of hem- angioblastomas of the central nervous system].

5. Is renin substrate an erythropoietin precursor?

6. Ultrastructure of cerebellar capillary hemangioblastoma. I. Weibel-Palade bodies and stromal cell histogenesis.

7. Cerebellar hemangioblastoma: erythropoietic activity by radioiron assay.

8. Pathological and haematological aspects of posterior fossa haemangioblastomata.

9. Erythropoietin and renin substrate in cerebellar haemangioblastoma.

10. A radioimmunoassay for erythropoietin: serum levels in normal human subjects and patients with hemopoietic disorders.

1. Histogenesis of stromal cells in cerebellar hemangioblastomas. An immunohistochemical study.

2. Vascular growth factors and receptors in capillary hemangioblastomas and hemangiopericytomas.