Jia Jia1, Xiang Li2, Xueyang Ren3, Xiaoyun Liu4, Yu Wang5, Ying Dong6, Xiaoping Wang7, Siqi Sun8, Xiao Xu9, Xiao Li10, Ruolan Song11, Jiamu Ma12, Axiang Yu13, Qiqi Fan14, Jing Wei15, Xin Yan16, Xiuhuan Wang17, Gaimei She18. 1. School of Chinese Pharmacy, Beijing University of Chinese Medicine, Beijing, 100029, China. Electronic address: jiajia09120912@163.com. 2. School of Chinese Pharmacy, Beijing University of Chinese Medicine, Beijing, 100029, China. Electronic address: 18343356599@163.com. 3. School of Chinese Pharmacy, Beijing University of Chinese Medicine, Beijing, 100029, China. Electronic address: renxueyang1996@163.com. 4. School of Chinese Pharmacy, Beijing University of Chinese Medicine, Beijing, 100029, China. Electronic address: liuxiaoyun9699@163.com. 5. School of Chinese Pharmacy, Beijing University of Chinese Medicine, Beijing, 100029, China. Electronic address: wangyu19970721@163.com. 6. School of Chinese Pharmacy, Beijing University of Chinese Medicine, Beijing, 100029, China. Electronic address: 15328226357@163.com. 7. School of Chinese Pharmacy, Beijing University of Chinese Medicine, Beijing, 100029, China. Electronic address: wangxiaopingcx@163.com. 8. School of Chinese Pharmacy, Beijing University of Chinese Medicine, Beijing, 100029, China. Electronic address: SunSiQi1279@163.com. 9. School of Chinese Pharmacy, Beijing University of Chinese Medicine, Beijing, 100029, China. Electronic address: xux_26@163.com. 10. School of Chinese Pharmacy, Beijing University of Chinese Medicine, Beijing, 100029, China. Electronic address: lixiaocherish@sina.com. 11. School of Chinese Pharmacy, Beijing University of Chinese Medicine, Beijing, 100029, China. Electronic address: songruolan@126.com. 12. School of Chinese Pharmacy, Beijing University of Chinese Medicine, Beijing, 100029, China. Electronic address: majiamu96@163.com. 13. School of Chinese Pharmacy, Beijing University of Chinese Medicine, Beijing, 100029, China. Electronic address: yuaxiang1011@163.com. 14. School of Chinese Pharmacy, Beijing University of Chinese Medicine, Beijing, 100029, China. Electronic address: ki_ki1998@163.com. 15. School of Chinese Pharmacy, Beijing University of Chinese Medicine, Beijing, 100029, China. Electronic address: Radiant-JJ@163.com. 16. School of Chinese Pharmacy, Beijing University of Chinese Medicine, Beijing, 100029, China. Electronic address: yanxinbucm@126.com. 17. School of Chinese Pharmacy, Beijing University of Chinese Medicine, Beijing, 100029, China. Electronic address: wangxiuhuan12340@163.com. 18. School of Chinese Pharmacy, Beijing University of Chinese Medicine, Beijing, 100029, China. Electronic address: shegaimei@126.com.
Abstract
ETHNOPHARMACOLOGICAL RELEVANCE: Sparganii Rhizoma (SR), a traditional Chinese medicine (TCM), is the rhizome of Sparganium stoloniferum Buch.-Ham. mainly distributed in East Asia. It has been used for eliminating blood stasis, promoting the flow of Qi, removing the retention of undigested food and relieving pain in China for hundreds of years. AIM OF THE REVIEW: This review summarizes comprehensive information in traditional clinical application, processing, phytochemistry, pharmacology, quality control and toxicity of SR, in exploring future scientific and therapeutic potentials. MATERIALS AND METHODS: Pertinent information was systematically collected from several electronic scientific databases (e.g., Web of Science, PubMed, China Knowledge Resource Integrated, Springer, Elsevier, ScienceDirect, and Google Scholar), PhD and MS dissertations, and classic Chinese medical books. RESULTS: SR is a gynecological drug which is often used to treat dysmenorrhea, mass in the abdomen, amenorrhea due to blood stasis, and abdominal distension in TCM. Two kinds of processed products of SR are included in Chinese Pharmacopoeia, which have better pharmacological effects than the crude herb. Approximately 180 compounds have been identified from SR, including phenylpropanoids, flavonoids, anthraquinones, organic acids, alkaloids, steroids, volatile oils, diarylheptanes, etc. The crude extracts and isolated components of SR have been reported to have anti-tumor, antithrombotic, estrogen antagonistic , anti-inflammatory, analgesic, antioxidant, anti organ fibrosis and other pharmacological activities. SR also has reproductive toxicity. CONCLUSIONS: As an important TCM, SR has been demonstrated by modern pharmacological researches to have significant bioactivities, especially on anti-tumor, antithrombotic, and estrogen antagonistic activities. These activities provide prospects for the development of new drugs and therapeutics for future applications. Nevertheless, quality control and evaluation, in-depth pharmacological mechanism, and toxicological effect of SR require further detailed research.
ETHNOPHARMACOLOGICAL RELEVANCE: Sparganii Rhizoma (SR), a traditional Chinese medicine (TCM), is the rhizome of Sparganium stoloniferum Buch.-Ham. mainly distributed in East Asia. It has been used for eliminating blood stasis, promoting the flow of Qi, removing the retention of undigested food and relieving pain in China for hundreds of years. AIM OF THE REVIEW: This review summarizes comprehensive information in traditional clinical application, processing, phytochemistry, pharmacology, quality control and toxicity of SR, in exploring future scientific and therapeutic potentials. MATERIALS AND METHODS: Pertinent information was systematically collected from several electronic scientific databases (e.g., Web of Science, PubMed, China Knowledge Resource Integrated, Springer, Elsevier, ScienceDirect, and Google Scholar), PhD and MS dissertations, and classic Chinese medical books. RESULTS:SR is a gynecological drug which is often used to treat dysmenorrhea, mass in the abdomen, amenorrhea due to blood stasis, and abdominal distension in TCM. Two kinds of processed products of SR are included in Chinese Pharmacopoeia, which have better pharmacological effects than the crude herb. Approximately 180 compounds have been identified from SR, including phenylpropanoids, flavonoids, anthraquinones, organic acids, alkaloids, steroids, volatile oils, diarylheptanes, etc. The crude extracts and isolated components of SR have been reported to have anti-tumor, antithrombotic, estrogen antagonistic , anti-inflammatory, analgesic, antioxidant, anti organ fibrosis and other pharmacological activities. SR also has reproductive toxicity. CONCLUSIONS: As an important TCM, SR has been demonstrated by modern pharmacological researches to have significant bioactivities, especially on anti-tumor, antithrombotic, and estrogen antagonistic activities. These activities provide prospects for the development of new drugs and therapeutics for future applications. Nevertheless, quality control and evaluation, in-depth pharmacological mechanism, and toxicological effect of SR require further detailed research.
Authors: Lin Zhao; Li Dong Ding; Zi Hao Xia; Peng Sheng; Meng Meng Shen; Zhong Ming Cai; Bing Chun Yan Journal: Front Pharmacol Date: 2022-03-23 Impact factor: 5.810