Mehrdad Afarid1, Fatemeh Sanie-Jahromi2. 1. Poostchi Ophthalmology Research Center, Shiraz University of Medical Sciences, Zand Boulevard, Poostchi Street, Shiraz, Iran. 2. Poostchi Ophthalmology Research Center, Shiraz University of Medical Sciences, Zand Boulevard, Poostchi Street, Shiraz, Iran. fsanie@sums.ac.ir.
Abstract
PURPOSES: Retinal neurodegenerative diseases are responsible for a huge number of ocular problems worldwide. It seems that the progression of these diseases can be managed by the application of neuroprotective molecules particularly in the early stages. This article focuses on the most common neuroprotective bioagents under investigation in ophthalmology. METHODS: We searched the web of science, PubMed and Scopus databases with these keywords: "glaucoma," "diabetic retinopathy," "age-related macular degeneration," "optic neuropathy and retinal degeneration" and/or "neuroprotection." RESULTS: The most commonly utilized neuroprotective drugs for ophthalmology diseases were introduced in this study. It seems that these agents can be divided into three categories according to their mechanism of action: (A) neurotrophins, (B) decreasing effect on intraocular pressure and (C) inhibition of retinal neuron apoptosis. CONCLUSION: A broad range of drugs has been illustrated in the literature for treatment of neuro-ophthalmic diseases. A good classification of the most applied drugs in this field can help specialists to prescribe the best matched drug considering the stage and progression of disease. However, controlled clinical trials are needed for better evaluation of the effects of these products.
PURPOSES: Retinal neurodegenerative diseases are responsible for a huge number of ocular problems worldwide. It seems that the progression of these diseases can be managed by the application of neuroprotective molecules particularly in the early stages. This article focuses on the most common neuroprotective bioagents under investigation in ophthalmology. METHODS: We searched the web of science, PubMed and Scopus databases with these keywords: "glaucoma," "diabetic retinopathy," "age-related macular degeneration," "optic neuropathy and retinal degeneration" and/or "neuroprotection." RESULTS: The most commonly utilized neuroprotective drugs for ophthalmology diseases were introduced in this study. It seems that these agents can be divided into three categories according to their mechanism of action: (A) neurotrophins, (B) decreasing effect on intraocular pressure and (C) inhibition of retinal neuron apoptosis. CONCLUSION: A broad range of drugs has been illustrated in the literature for treatment of neuro-ophthalmic diseases. A good classification of the most applied drugs in this field can help specialists to prescribe the best matched drug considering the stage and progression of disease. However, controlled clinical trials are needed for better evaluation of the effects of these products.
Authors: Alexander A Shpak; Alla B Guekht; Tatiana A Druzhkova; Ksenia I Kozlova; Natalia V Gulyaeva Journal: Curr Eye Res Date: 2017-11-09 Impact factor: 2.424
Authors: M Shamsul Ola; Mohd Imtiaz Nawaz; Ahmed Abu El-Asrar; Marwan Abouammoh; Abdullah S Alhomida Journal: Cell Mol Neurobiol Date: 2012-12-28 Impact factor: 5.046