Kansurang Chansawang1, Attawood Lertpimonchai1,2, Nisachon Siripaiboonpong1,2, Lalitsara Thienpramuk3, Prin Vathesatogkit4, Thosaphol Limpijankit4, Orawan Charatkulangkun5,6. 1. Department of Periodontology, Faculty of Dentistry, Chulalongkorn University, 34 Henri-Dunant Road, Pathumwan, Bangkok, 10330, Thailand. 2. Center of Excellence in Periodontal Disease and Dental Implant, Chulalongkorn University, Bangkok, 10330, Thailand. 3. Electricity Generating Authority of Thailand, Nonthaburi, 11130, Thailand. 4. Ramathibodi Hospital, Mahidol University, Bangkok, 10400, Thailand. 5. Department of Periodontology, Faculty of Dentistry, Chulalongkorn University, 34 Henri-Dunant Road, Pathumwan, Bangkok, 10330, Thailand. orawandds@gmail.com. 6. Center of Excellence in Periodontal Disease and Dental Implant, Chulalongkorn University, Bangkok, 10330, Thailand. orawandds@gmail.com.
Abstract
OBJECTIVES: To evaluate the association between the severity and extent of periodontitis and arterial stiffness using the cardio-ankle vascular index (CAVI). MATERIALS AND METHODS: A cross-sectional study of 2888 Electricity Generation Authority of Thailand (EGAT) employees aged 44-78 years was conducted. The severity of periodontitis was evaluated based on mean clinical attachment level (CAL). The percentage of sites with CAL ≥ 5 mm was used to divide the extent of periodontitis into healthy (0%), localized (> 0-< 30%), and generalized (≥ 30%). The CAVI value, a novel blood pressure-independent arterial stiffness parameter, was analyzed as both continuous and categorical data (low: < 9 or high: ≥ 9). Regression analysis was used to estimate the level of association. RESULTS: The participants demonstrated a mean CAL, % sites with CAL ≥ 5 mm, and a CAVI value of 3.2 ± 1.2 mm, 16.0 ± 20.8%, and 8.24 ± 1.12, respectively. Higher mean CAVI was observed with greater mean CAL and % sites with CAL ≥ 5 mm. The mean CAVI of the healthy, localized, and generalized periodontitis groups were 8.01 ± 1.11, 8.22 ± 1.12, and 8.51 ± 1.04, respectively (p < 0.01). Linear and logistic regression analysis demonstrated a significant relationship between CAVI and all periodontal variables with β = 0.004-0.17 and OR = 1.01-1.58, respectively. CONCLUSIONS: There is a significant dose-dependent association between the severity and extent of periodontitis and arterial stiffness measured by CAVI in Thai adults. CLINICAL RELEVANCE: Preventing arterial stiffness, an early sign of cardiovascular events, by controlling the emerging risk factors, such as periodontitis, might have a high impact on health promotion.
OBJECTIVES: To evaluate the association between the severity and extent of periodontitis and arterial stiffness using the cardio-ankle vascular index (CAVI). MATERIALS AND METHODS: A cross-sectional study of 2888 Electricity Generation Authority of Thailand (EGAT) employees aged 44-78 years was conducted. The severity of periodontitis was evaluated based on mean clinical attachment level (CAL). The percentage of sites with CAL ≥ 5 mm was used to divide the extent of periodontitis into healthy (0%), localized (> 0-< 30%), and generalized (≥ 30%). The CAVI value, a novel blood pressure-independent arterial stiffness parameter, was analyzed as both continuous and categorical data (low: < 9 or high: ≥ 9). Regression analysis was used to estimate the level of association. RESULTS: The participants demonstrated a mean CAL, % sites with CAL ≥ 5 mm, and a CAVI value of 3.2 ± 1.2 mm, 16.0 ± 20.8%, and 8.24 ± 1.12, respectively. Higher mean CAVI was observed with greater mean CAL and % sites with CAL ≥ 5 mm. The mean CAVI of the healthy, localized, and generalized periodontitis groups were 8.01 ± 1.11, 8.22 ± 1.12, and 8.51 ± 1.04, respectively (p < 0.01). Linear and logistic regression analysis demonstrated a significant relationship between CAVI and all periodontal variables with β = 0.004-0.17 and OR = 1.01-1.58, respectively. CONCLUSIONS: There is a significant dose-dependent association between the severity and extent of periodontitis and arterial stiffness measured by CAVI in Thai adults. CLINICAL RELEVANCE: Preventing arterial stiffness, an early sign of cardiovascular events, by controlling the emerging risk factors, such as periodontitis, might have a high impact on health promotion.
Authors: Peter B Lockhart; Ann F Bolger; Panos N Papapanou; Olusegun Osinbowale; Maurizio Trevisan; Matthew E Levison; Kathryn A Taubert; Jane W Newburger; Heather L Gornik; Michael H Gewitz; Walter R Wilson; Sidney C Smith; Larry M Baddour Journal: Circulation Date: 2012-04-18 Impact factor: 29.690
Authors: N M van Popele; D E Grobbee; M L Bots; R Asmar; J Topouchian; R S Reneman; A P Hoeks; D A van der Kuip ; A Hofman; J C Witteman Journal: Stroke Date: 2001-02 Impact factor: 7.914
Authors: W Houcken; W J Teeuw; S Bizzarro; E Alvarez Rodriguez; T A Mulders; B-Jh van den Born; B G Loos Journal: J Hum Hypertens Date: 2015-05-14 Impact factor: 3.012
Authors: Kostas Kapellas; Lisa M Jamieson; Loc G Do; P Mark Bartold; Hao Wang; Louise J Maple-Brown; David Sullivan; Kerin O'Dea; Alex Brown; David S Celermajer; Gary D Slade; Michael R Skilton Journal: Int J Cardiol Date: 2014-02-22 Impact factor: 4.164
Authors: Mariano Sanz; Antonio Ceriello; Martin Buysschaert; Iain Chapple; Ryan T Demmer; Filippo Graziani; David Herrera; Søren Jepsen; Luca Lione; Phoebus Madianos; Manu Mathur; Eduard Montanya; Lior Shapira; Maurizio Tonetti; Daniel Vegh Journal: Diabetes Res Clin Pract Date: 2017-12-05 Impact factor: 5.602
Authors: Yvonne Jockel-Schneider; Inga Harks; Imme Haubitz; Stefan Fickl; Martin Eigenthaler; Ulrich Schlagenhauf; Johannes Baulmann Journal: PLoS One Date: 2014-08-01 Impact factor: 3.240
Authors: Stanisław Surma; Monika Romańczyk; Justyna Witalińska-Łabuzek; Maciej R Czerniuk; Krzysztof Łabuzek; Krzysztof J Filipiak Journal: Curr Hypertens Rep Date: 2021-05-07 Impact factor: 5.369