| Literature DB >> 33179437 |
Yuk-Lin Yung1, Chi-Keung Cheng1, Hoi-Yun Chan1, Jenny T Xia1, Kin-Mang Lau1, Raymond S M Wong2,3, Alan K L Wu4, Raymond W Chu4, Alice C C Wong5, Eudora Y D Chow5, Sze-Fai Yip6, Jennifer N S Leung7, Cheuk-Kwong Lee7, Margaret H L Ng1,8.
Abstract
The coronavirus disease 2019 (COVID-19) is a highly infectious disease caused by SARS-CoV-2. Since its first report in December 2019, COVID-19 has evolved into a global pandemic causing massive healthcare and socioeconomic challenges. HLA system is critical in mediating anti-viral immunity and recent studies have suggested preferential involvement of HLA-B in COVID-19 susceptibility. Here, by investigating the HLA-B genotypes in 190 unrelated Chinese patients with confirmed COVID-19, we identified a significant positive association between the B22 serotype and SARS-CoV-2 infection (p = 0.002, Bonferroni-corrected p = 0.032). Notably, the B22 serotype has been consistently linked to susceptibility to other viral infections. These data not only shed new insights into SARS-CoV-2 pathogenesis and vaccine development but also guide better infection prevention/control.Entities:
Keywords: COVID-19; Chinese; HLA; SARS-CoV-2; coronavirus
Year: 2020 PMID： 33179437 DOI： 10.1111/tan.14135
Source DB: PubMed Journal: HLA ISSN： 2059-2302 Impact factor: 4.513