Literature DB >> 3317825

Development of the primary antibody repertoire.

F W Alt1, T K Blackwell, G D Yancopoulos.   

Abstract

The ability to generate a diverse immune response depends on the somatic assembly of genes that encode the antigen-binding portions of immunoglobulin molecules. In this article, we discuss the mechanism and control of these genomic rearrangement events and how aspects of this process are involved in generating the primary antibody repertoire.

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Year:  1987        PMID： 3317825     DOI： 10.1126/science.3317825

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  163 in total

1.  Systematic characterization of porcine ileal Peyer's patch, I. apoptosis-sensitive immature B cells are the predominant cell type.

Authors:  J K Andersen; H Takamatsu; C A Oura; S M Brookes; L Pullen; R E Parkhouse
Journal:  Immunology       Date:  1999-12       Impact factor: 7.397

2.  V(D)J recombination is not activated by demethylation of the kappa locus.

Authors:  S R Cherry; C Beard; R Jaenisch; D Baltimore
Journal:  Proc Natl Acad Sci U S A       Date:  2000-07-18       Impact factor: 11.205

3.  Micronuclear genome organization in Euplotes crassus: a transposonlike element is removed during macronuclear development.

Authors:  S E Baird; G M Fino; S L Tausta; L A Klobutcher
Journal:  Mol Cell Biol       Date:  1989-09       Impact factor: 4.272

4.  Contributions of conventional and heavy-chain IgG to immunity in fetal, neonatal, and adult alpacas.

Authors:  L P Daley-Bauer; S R Purdy; M C Smith; L F Gagliardo; W C Davis; J A Appleton
Journal:  Clin Vaccine Immunol       Date:  2010-10-06

Review 5.  Natural genetic engineering in evolution.

Authors:  J A Shapiro
Journal:  Genetica       Date:  1992       Impact factor: 1.082

6.  Ectopic recombination within homologous immunoglobulin mu gene constant regions in a mouse hybridoma cell line.

Authors:  M D Baker; L R Read
Journal:  Mol Cell Biol       Date:  1992-10       Impact factor: 4.272

7.  The T cell receptor beta enhancer promotes access and pairing of Dbeta and Jbeta gene segments during V(D)J recombination.

Authors:  Chun Jeih Ryu; Brian B Haines; Dobrin D Draganov; Yun Hee Kang; Charles E Whitehurst; Tara Schmidt; Hyo Jeong Hong; Jianzhu Chen
Journal:  Proc Natl Acad Sci U S A       Date:  2003-10-30       Impact factor: 11.205

8.  Transcriptional regulatory elements stimulate recombination in extrachromosomal substrates carrying immunoglobulin switch-region sequences.

Authors:  H Leung; N Maizels
Journal:  Proc Natl Acad Sci U S A       Date:  1992-05-01       Impact factor: 11.205

9.  Transcription of germ line V alpha segments correlates with ongoing T-cell receptor alpha-chain rearrangement.

Authors:  J D Fondell; K B Marcu
Journal:  Mol Cell Biol       Date:  1992-04       Impact factor: 4.272

10.  Microarray profiling of antibody responses against simian-human immunodeficiency virus: postchallenge convergence of reactivities independent of host histocompatibility type and vaccine regimen.

Authors:  Henry E Neuman de Vegvar; Rama Rao Amara; Lawrence Steinman; Paul J Utz; Harriet L Robinson; William H Robinson
Journal:  J Virol       Date:  2003-10       Impact factor: 5.103
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