Literature DB >> 33176521

M6A Regulatory Genes Play an Important Role in the Prognosis, Progression and Immune Microenvironment of Pancreatic Adenocarcinoma.

Fangshi Xu1, Zhengliang Zhang2, Miao Yuan2, Yidi Zhao2, Yang Zhou2, Honghong Pei2, Ling Bai2.   

Abstract

The specific roles of N6-methyladenosine (m6A) regulatory genes in pancreatic adenocarcinoma (PAAD) have not been fully elucidated. In present study, a novel risk signature was constructed by five m6A-related genes (including METTL3, METTL14, KIAA1429, ALKBH5 and YTHDF1) and was identified as an independent prognostic factor (HR = 13.192) via TCGA (185 samples) databases. The immune abundances of 22 leukocyte subtypes in each PAAD sample were exhibited via the CIBERSORT algorithm. High risk group promoted infiltration levels of Macrophages M0 and M2 cells and decreased that of B cells naive, T cells CD8 and T regulatory cells.

Entities:  

Keywords:  N6-methyladenosine; Pancreatic adenocarcinoma; immune microenvironment; prognosis; risk signature

Year:  2020        PMID： 33176521     DOI： 10.1080/07357907.2020.1834576

Source DB:  PubMed          Journal:  Cancer Invest        ISSN： 0735-7907            Impact factor:   2.176


  17 in total

1.  N7-Methylguanosine Regulatory Genes Profoundly Affect the Prognosis, Progression, and Antitumor Immune Response of Hepatocellular Carcinoma.

Authors:  Kexiang Zhou; Jiaqun Yang; Xiaoyan Li; Wei Xiong; Pengbin Zhang; Xuqing Zhang
Journal:  Front Surg       Date:  2022-06-16

2.  Bioinformatic analyses and experimental validation of the role of m6A RNA methylation regulators in progression and prognosis of adrenocortical carcinoma.

Authors:  Fangshi Xu; Yibing Guan; Yubo Ma; Li Xue; Peng Zhang; Xiaojie Yang; Tie Chong
Journal:  Aging (Albany NY)       Date:  2021-04-21       Impact factor: 5.682

3.  Two types of immune infiltrating cells and six hub genes can predict the occurrence of myasthenia gravis in patients with thymoma.

Authors:  Ziyou Tao; Chao Lu; Shuai Gao; Peng Zhang; Yuan Chen; Yuanguo Wang; Zhaoyu Yang; Kai Xiong; Yuxin Liu; Peng Zhang
Journal:  Bioengineered       Date:  2021-12       Impact factor: 3.269

4.  A synthesized olean-28,13β-lactam targets YTHDF1-GLS1 axis to induce ROS-dependent metabolic crisis and cell death in pancreatic adenocarcinoma.

Authors:  Shijia Wu; Yong Ai; Huimin Huang; Guangyu Wu; Shipeng Zhou; Weilong Hong; Percy David Papa Akuetteh; Guihua Jin; Xingling Zhao; Yihua Zhang; Xiaolong Zhang; Linhua Lan
Journal:  Cancer Cell Int       Date:  2022-04-02       Impact factor: 5.722

5.  Identification of an autophagy-related gene signature for predicting prognosis and immune activity in pancreatic adenocarcinoma.

Authors:  Jiang Deng; Qian Zhang; Liping Lv; Ping Ma; Yangyang Zhang; Ning Zhao; Yanyu Zhang
Journal:  Sci Rep       Date:  2022-04-29       Impact factor: 4.996

6.  M5C regulator-mediated methylation modification patterns and tumor microenvironment infiltration characterization in lung adenocarcinoma.

Authors:  Hui Chen; Xiao-Lin Ge; Zhao-Yue Zhang; Ming Liu; Rui-Yan Wu; Xiao-Fei Zhang; Li-Ping Xu; Hong-Yan Cheng; Xin-Chen Sun; Hong-Cheng Zhu
Journal:  Transl Lung Cancer Res       Date:  2021-05

Review 7.  N6-methyladenosine (m6A) in pancreatic cancer: Regulatory mechanisms and future direction.

Authors:  Jian Li; Fangjuan Wang; Yongkang Liu; Huaizhi Wang; Bing Ni
Journal:  Int J Biol Sci       Date:  2021-06-04       Impact factor: 6.580

Review 8.  Function and clinical significance of N6-methyladenosine in digestive system tumours.

Authors:  Junchao Huang; Yingjie Shao; Wendong Gu
Journal:  Exp Hematol Oncol       Date:  2021-07-10

9.  Identification of an Autophagy-Related Pair Signature for Predicting Prognoses and Immune Activity in Pancreatic Adenocarcinoma.

Authors:  Qian Zhang; Liping Lv; Ping Ma; Yangyang Zhang; Jiang Deng; Yanyu Zhang
Journal:  Front Immunol       Date:  2021-12-09       Impact factor: 7.561

Review 10.  N6-Methyladenosine RNA Modification in the Tumor Immune Microenvironment: Novel Implications for Immunotherapy.

Authors:  Liting Guo; Hui Yang; Chenfei Zhou; Yan Shi; Lei Huang; Jun Zhang
Journal:  Front Immunol       Date:  2021-12-09       Impact factor: 7.561
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