Literature DB >> 33175425

COVID-19 lessons from the dish: Dissecting CNS manifestations through brain organoids.

Nicolò Caporale1,2,3, Giuseppe Testa1,2,3.   

Abstract

COVID-19 is increasingly understood as a systemic disease with pathogenic manifestations beyond the respiratory tract. Recent work by Ramani et al (2020) dissects the cellular and molecular mechanisms of SARS-CoV-2's neurotrophic properties, using viral exposure of human brain organoids. Their findings highlight neurons as primary target of cerebral SARS-CoV-2 infection and uncover its Tau-related neurotoxicity.
© 2020 The Authors.

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Year:  2020        PMID： 33175425      PMCID： PMC7809698          DOI： 10.15252/embj.2020107213

Source DB:  PubMed          Journal:  EMBO J        ISSN： 0261-4189            Impact factor:   11.598


  11 in total

1.  Recent Zika Virus Isolates Induce Premature Differentiation of Neural Progenitors in Human Brain Organoids.

Authors:  Elke Gabriel; Anand Ramani; Ulrike Karow; Marco Gottardo; Karthick Natarajan; Li Ming Gooi; Gladiola Goranci-Buzhala; Oleg Krut; Franziska Peters; Milos Nikolic; Suvi Kuivanen; Essi Korhonen; Teemu Smura; Olli Vapalahti; Argyris Papantonis; Jonas Schmidt-Chanasit; Maria Riparbelli; Giuliano Callaini; Martin Krönke; Olaf Utermöhlen; Jay Gopalakrishnan
Journal:  Cell Stem Cell       Date:  2017-01-26       Impact factor: 24.633

Review 2.  Human organoids: model systems for human biology and medicine.

Authors:  Jihoon Kim; Bon-Kyoung Koo; Juergen A Knoblich
Journal:  Nat Rev Mol Cell Biol       Date:  2020-07-07       Impact factor: 94.444

3.  Human Cortical Organoids Expose a Differential Function of GSK3 on Cortical Neurogenesis.

Authors:  Alejandro López-Tobón; Carlo Emanuele Villa; Cristina Cheroni; Sebastiano Trattaro; Nicolò Caporale; Paola Conforti; Raffaele Iennaco; Maria Lachgar; Marco Tullio Rigoli; Berta Marcó de la Cruz; Pietro Lo Riso; Erika Tenderini; Flavia Troglio; Marco De Simone; Isabel Liste-Noya; Giuseppe Macino; Massimiliano Pagani; Elena Cattaneo; Giuseppe Testa
Journal:  Stem Cell Reports       Date:  2019-10-10       Impact factor: 7.765

4.  Neuropathology of patients with COVID-19 in Germany: a post-mortem case series.

Authors:  Jakob Matschke; Marc Lütgehetmann; Christian Hagel; Jan P Sperhake; Ann Sophie Schröder; Carolin Edler; Herbert Mushumba; Antonia Fitzek; Lena Allweiss; Maura Dandri; Matthias Dottermusch; Axel Heinemann; Susanne Pfefferle; Marius Schwabenland; Daniel Sumner Magruder; Stefan Bonn; Marco Prinz; Christian Gerloff; Klaus Püschel; Susanne Krasemann; Martin Aepfelbacher; Markus Glatzel
Journal:  Lancet Neurol       Date:  2020-10-05       Impact factor: 44.182

Review 5.  Neurological associations of COVID-19.

Authors:  Mark A Ellul; Laura Benjamin; Bhagteshwar Singh; Suzannah Lant; Benedict Daniel Michael; Ava Easton; Rachel Kneen; Sylviane Defres; Jim Sejvar; Tom Solomon
Journal:  Lancet Neurol       Date:  2020-07-02       Impact factor: 44.182

6.  Severe COVID-19 Is Marked by a Dysregulated Myeloid Cell Compartment.

Authors:  Jonas Schulte-Schrepping; Nico Reusch; Daniela Paclik; Kevin Baßler; Stephan Schlickeiser; Bowen Zhang; Benjamin Krämer; Tobias Krammer; Sophia Brumhard; Lorenzo Bonaguro; Elena De Domenico; Daniel Wendisch; Martin Grasshoff; Theodore S Kapellos; Michael Beckstette; Tal Pecht; Adem Saglam; Oliver Dietrich; Henrik E Mei; Axel R Schulz; Claudia Conrad; Désirée Kunkel; Ehsan Vafadarnejad; Cheng-Jian Xu; Arik Horne; Miriam Herbert; Anna Drews; Charlotte Thibeault; Moritz Pfeiffer; Stefan Hippenstiel; Andreas Hocke; Holger Müller-Redetzky; Katrin-Moira Heim; Felix Machleidt; Alexander Uhrig; Laure Bosquillon de Jarcy; Linda Jürgens; Miriam Stegemann; Christoph R Glösenkamp; Hans-Dieter Volk; Christine Goffinet; Markus Landthaler; Emanuel Wyler; Philipp Georg; Maria Schneider; Chantip Dang-Heine; Nick Neuwinger; Kai Kappert; Rudolf Tauber; Victor Corman; Jan Raabe; Kim Melanie Kaiser; Michael To Vinh; Gereon Rieke; Christian Meisel; Thomas Ulas; Matthias Becker; Robert Geffers; Martin Witzenrath; Christian Drosten; Norbert Suttorp; Christof von Kalle; Florian Kurth; Kristian Händler; Joachim L Schultze; Anna C Aschenbrenner; Yang Li; Jacob Nattermann; Birgit Sawitzki; Antoine-Emmanuel Saliba; Leif Erik Sander
Journal:  Cell       Date:  2020-08-05       Impact factor: 41.582

7.  LifeTime and improving European healthcare through cell-based interceptive medicine.

Authors:  Nikolaus Rajewsky; Geneviève Almouzni; Stanislaw A Gorski; Stein Aerts; Ido Amit; Michela G Bertero; Christoph Bock; Annelien L Bredenoord; Giacomo Cavalli; Susanna Chiocca; Hans Clevers; Bart De Strooper; Angelika Eggert; Jan Ellenberg; Xosé M Fernández; Marek Figlerowicz; Susan M Gasser; Norbert Hubner; Jørgen Kjems; Jürgen A Knoblich; Grietje Krabbe; Peter Lichter; Sten Linnarsson; Jean-Christophe Marine; John C Marioni; Marc A Marti-Renom; Mihai G Netea; Dörthe Nickel; Marcelo Nollmann; Halina R Novak; Helen Parkinson; Stefano Piccolo; Inês Pinheiro; Ana Pombo; Christian Popp; Wolf Reik; Sergio Roman-Roman; Philip Rosenstiel; Joachim L Schultze; Oliver Stegle; Amos Tanay; Giuseppe Testa; Dimitris Thanos; Fabian J Theis; Maria-Elena Torres-Padilla; Alfonso Valencia; Céline Vallot; Alexander van Oudenaarden; Marie Vidal; Thierry Voet
Journal:  Nature       Date:  2020-09-07       Impact factor: 49.962

8.  Identification of Required Host Factors for SARS-CoV-2 Infection in Human Cells.

Authors:  Zharko Daniloski; Tristan X Jordan; Hans-Hermann Wessels; Daisy A Hoagland; Silva Kasela; Mateusz Legut; Silas Maniatis; Eleni P Mimitou; Lu Lu; Evan Geller; Oded Danziger; Brad R Rosenberg; Hemali Phatnani; Peter Smibert; Tuuli Lappalainen; Benjamin R tenOever; Neville E Sanjana
Journal:  Cell       Date:  2020-10-24       Impact factor: 41.582

9.  SARS-CoV-2 Infects the Brain Choroid Plexus and Disrupts the Blood-CSF Barrier in Human Brain Organoids.

Authors:  Laura Pellegrini; Anna Albecka; Donna L Mallery; Max J Kellner; David Paul; Andrew P Carter; Leo C James; Madeline A Lancaster
Journal:  Cell Stem Cell       Date:  2020-10-13       Impact factor: 24.633

10.  SARS-CoV-2 targets neurons of 3D human brain organoids.

Authors:  Anand Ramani; Lisa Müller; Philipp N Ostermann; Elke Gabriel; Pranty Abida-Islam; Andreas Müller-Schiffmann; Aruljothi Mariappan; Olivier Goureau; Henning Gruell; Andreas Walker; Marcel Andrée; Sandra Hauka; Torsten Houwaart; Alexander Dilthey; Kai Wohlgemuth; Heymut Omran; Florian Klein; Dagmar Wieczorek; Ortwin Adams; Jörg Timm; Carsten Korth; Heiner Schaal; Jay Gopalakrishnan
Journal:  EMBO J       Date:  2020-09-23       Impact factor: 11.598
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  2 in total

Review 1.  Pathogenic Mechanism and Multi-omics Analysis of Oral Manifestations in COVID-19.

Authors:  Ming Hao; Dongxu Wang; Qianyun Xia; Shaoning Kan; Lu Chang; Huimin Liu; Zhijing Yang; Weiwei Liu
Journal:  Front Immunol       Date:  2022-07-04       Impact factor: 8.786

Review 2.  [COVID-19 and the central and peripheral nervous system].

Authors:  N Ritschel; H Radbruch; C Herden; N Schneider; C Dittmayer; J Franz; C Thomas; G Silva Boos; A Pagenstecher; W Schulz-Schaeffer; C Stadelmann; M Glatzel; F L Heppner; J Weis; K Sohrabi; A Schänzer; A Németh; T Acker
Journal:  Pathologe       Date:  2021-03-01       Impact factor: 1.011
  2 in total

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