Literature DB >> 33173189

Therapeutic strategies targeting FOXO transcription factors.

Giampaolo Calissi1, Eric W-F Lam2, Wolfgang Link3.   

Abstract

FOXO proteins are transcription factors that are involved in numerous physiological processes and in various pathological conditions, including cardiovascular disease, cancer, diabetes and chronic neurological diseases. For example, FOXO proteins are context-dependent tumour suppressors that are frequently inactivated in human cancers, and FOXO3 is the second most replicated gene associated with extreme human longevity. Therefore, pharmacological manipulation of FOXO proteins is a promising approach to developing therapeutics for cancer and for healthy ageing. In this Review, we overview the role of FOXO proteins in health and disease and discuss the pharmacological approaches to modulate FOXO function.

Entities:  

Year:  2020        PMID： 33173189     DOI： 10.1038/s41573-020-0088-2

Source DB:  PubMed          Journal:  Nat Rev Drug Discov        ISSN： 1474-1776            Impact factor:   84.694


  38 in total

1.  DNA methylation and transcription of the FOXO3a gene are associated with ankylosing spondylitis.

Authors:  Shanshan Xu; Xiaoyi Zhang; Xinqi Wang; Huimin Xie; Feier Wang; Tingting Zhou; Lingxiang Yu; Shengqian Xu; Faming Pan
Journal:  Clin Exp Med       Date:  2022-05-05       Impact factor: 3.984

2.  Soluble RAGE attenuates myocardial I/R injuries via FoxO3-Bnip3 pathway.

Authors:  Jie Zhang; Xuejie Han; Jing Chang; Jian Liu; Yingming Liu; Hongxia Wang; Fenghe Du; Xiangjun Zeng; Caixia Guo
Journal:  Cell Mol Life Sci       Date:  2022-05-02       Impact factor: 9.261

Review 3.  Regulation of endothelial progenitor cell functions during hyperglycemia: new therapeutic targets in diabetic wound healing.

Authors:  Gui Wan; Yangyang Chen; Jing Chen; Chengqi Yan; Cheng Wang; Wenqing Li; Renqun Mao; Hans-Günther Machens; Xiaofan Yang; Zhenbing Chen
Journal:  J Mol Med (Berl)       Date:  2022-01-08       Impact factor: 4.599

Review 4.  MicroRNAs and Corresponding Targets in Esophageal Cancer as Shown In Vitro and In Vivo in Preclinical Models.

Authors:  Ulrich H Weidle; Adam Nopora
Journal:  Cancer Genomics Proteomics       Date:  2022 Mar-Apr       Impact factor: 4.069

Review 5.  Cell Biology Meets Cell Metabolism: Energy Production Is Similar in Stem Cells and in Cancer Stem Cells in Brain and Bone Marrow.

Authors:  Cornelis J F van Noorden; Barbara Breznik; Metka Novak; Amber J van Dijck; Saloua Tanan; Miloš Vittori; Urban Bogataj; Noëlle Bakker; Joseph D Khoury; Remco J Molenaar; Vashendriya V V Hira
Journal:  J Histochem Cytochem       Date:  2021-10-29       Impact factor: 2.479

Review 6.  Evaluating the beneficial effects of dietary restrictions: A framework for precision nutrigeroscience.

Authors:  Kenneth A Wilson; Manish Chamoli; Tyler A Hilsabeck; Manish Pandey; Sakshi Bansal; Geetanjali Chawla; Pankaj Kapahi
Journal:  Cell Metab       Date:  2021-09-22       Impact factor: 31.373

7.  Elucidation of endothelial progenitor cell dysfunction in diabetes by RNA sequencing and constructing lncRNA-miRNA-mRNA competing endogenous RNA network.

Authors:  Gui Wan; Zhao Xu; Xuejiao Xiang; Maojie Zhang; Tao Jiang; Jing Chen; Shengbo Li; Cheng Wang; Chengqi Yan; Xiaofan Yang; Zhenbing Chen
Journal:  J Mol Med (Berl)       Date:  2022-09-12       Impact factor: 5.606

Review 8.  The FOXO family of transcription factors: key molecular players in gastric cancer.

Authors:  Ying Liu; Xiang Ao; Yi Jia; Xiaoge Li; Yu Wang; Jianxun Wang
Journal:  J Mol Med (Berl)       Date:  2022-06-10       Impact factor: 5.606

Review 9.  Forkhead Box Protein O1: Functional Diversity and Post-Translational Modification, a New Therapeutic Target?

Authors:  Xiaojun Zhang; Lusheng Jiang; Huimin Liu
Journal:  Drug Des Devel Ther       Date:  2021-05-03       Impact factor: 4.162

10.  Aulosirazoles B and C from the Cyanobacterium Nostoc sp. UIC 10771: Analogues of an Isothiazolonaphthoquinone Scaffold that Activate Nuclear Transcription Factor FOXO3a in Ovarian Cancer Cells.

Authors:  Lydia J Davis; Amanda C Maldonado; Manead Khin; Aleksej Krunic; Joanna E Burdette; Jimmy Orjala
Journal:  J Nat Prod       Date:  2022-01-31       Impact factor: 4.050
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