Imran Chaudhri1, Richard Moffitt2, Erin Taub1, Raji R Annadi3, Minh Hoai3, Olena Bolotova1, Jeanwoo Yoo1, Simrat Dhaliwal1, Haseena Sahib1, Farah Daccueil1, Janos Hajagos2, Mary Saltz2, Joel Saltz2, Sandeep K Mallipattu1,4, Farrukh M Koraishy5,6. 1. Division of Nephrology and Hypertension, Department of Medicine, Stony Brook University, Stony Brook, New York, USA. 2. Department of Biomedical Informatics, Stony Brook University, Stony Brook, New York, USA. 3. Department of Computer Science, Stony Brook University, Stony Brook, New York, USA. 4. Renal Section, Northport VA Medical Center, Northport, New York, USA. 5. Division of Nephrology and Hypertension, Department of Medicine, Stony Brook University, Stony Brook, New York, USA, Farrukh.Koraishy@stonybrookmedicine.edu. 6. Renal Section, Northport VA Medical Center, Northport, New York, USA, Farrukh.Koraishy@stonybrookmedicine.edu.
Abstract
INTRODUCTION: Acute kidney injury (AKI) is strongly associated with poor outcomes in hospitalized patients with coronavirus disease 2019 (COVID-19), but data on the association of proteinuria and hematuria are limited to non-US populations. In addition, admission and in-hospital measures for kidney abnormalities have not been studied separately. METHODS: This retrospective cohort study aimed to analyze these associations in 321 patients sequentially admitted between March 7, 2020 and April 1, 2020 at Stony Brook University Medical Center, New York. We investigated the association of proteinuria, hematuria, and AKI with outcomes of inflammation, intensive care unit (ICU) admission, invasive mechanical ventilation (IMV), and in-hospital death. We used ANOVA, t test, χ2 test, and Fisher's exact test for bivariate analyses and logistic regression for multivariable analysis. RESULTS: Three hundred patients met the inclusion criteria for the study cohort. Multivariable analysis demonstrated that admission proteinuria was significantly associated with risk of in-hospital AKI (OR 4.71, 95% CI 1.28-17.38), while admission hematuria was associated with ICU admission (OR 4.56, 95% CI 1.12-18.64), IMV (OR 8.79, 95% CI 2.08-37.00), and death (OR 18.03, 95% CI 2.84-114.57). During hospitalization, de novo proteinuria was significantly associated with increased risk of death (OR 8.94, 95% CI 1.19-114.4, p = 0.04). In-hospital AKI increased (OR 27.14, 95% CI 4.44-240.17) while recovery from in-hospital AKI decreased the risk of death (OR 0.001, 95% CI 0.001-0.06). CONCLUSION: Proteinuria and hematuria both at the time of admission and during hospitalization are associated with adverse clinical outcomes in hospitalized patients with COVID-19.
INTRODUCTION:Acute kidney injury (AKI) is strongly associated with poor outcomes in hospitalized patients with coronavirus disease 2019 (COVID-19), but data on the association of proteinuria and hematuria are limited to non-US populations. In addition, admission and in-hospital measures for kidney abnormalities have not been studied separately. METHODS: This retrospective cohort study aimed to analyze these associations in 321 patients sequentially admitted between March 7, 2020 and April 1, 2020 at Stony Brook University Medical Center, New York. We investigated the association of proteinuria, hematuria, and AKI with outcomes of inflammation, intensive care unit (ICU) admission, invasive mechanical ventilation (IMV), and in-hospital death. We used ANOVA, t test, χ2 test, and Fisher's exact test for bivariate analyses and logistic regression for multivariable analysis. RESULTS: Three hundred patients met the inclusion criteria for the study cohort. Multivariable analysis demonstrated that admission proteinuria was significantly associated with risk of in-hospital AKI (OR 4.71, 95% CI 1.28-17.38), while admission hematuria was associated with ICU admission (OR 4.56, 95% CI 1.12-18.64), IMV (OR 8.79, 95% CI 2.08-37.00), and death (OR 18.03, 95% CI 2.84-114.57). During hospitalization, de novo proteinuria was significantly associated with increased risk of death (OR 8.94, 95% CI 1.19-114.4, p = 0.04). In-hospital AKI increased (OR 27.14, 95% CI 4.44-240.17) while recovery from in-hospital AKI decreased the risk of death (OR 0.001, 95% CI 0.001-0.06). CONCLUSION:Proteinuria and hematuria both at the time of admission and during hospitalization are associated with adverse clinical outcomes in hospitalized patients with COVID-19.
Authors: A Cau; M P Cheng; Terry Lee; A Levin; T C Lee; D C Vinh; F Lamontagne; J Singer; K R Walley; S Murthy; D Patrick; O Rewa; B Winston; J Marshall; J Boyd; J A Russell Journal: Can J Kidney Health Dis Date: 2021-10-30
Authors: Farrukh M Koraishy; Steven G Coca; Beth E Cohen; Jeffery F Scherrer; Frank Mann; Pei-Fen Kuan; Benjamin J Luft; Sean A P Clouston Journal: Psychosom Med Date: 2021 Nov-Dec 01 Impact factor: 4.312
Authors: Khaled S Allemailem; Ahmad Almatroudi; Amjad Ali Khan; Arshad H Rahmani; Ibrahim S Almarshad; Fahad S Alekezem; Nagwa Hassanein; Asmaa M El-Kady Journal: PLoS One Date: 2021-07-15 Impact factor: 3.240
Authors: Halie M Rando; Tellen D Bennett; James Brian Byrd; Carolyn Bramante; Tiffany J Callahan; Christopher G Chute; Hannah E Davis; Rachel Deer; Joel Gagnier; Farrukh M Koraishy; Feifan Liu; Julie A McMurry; Richard A Moffitt; Emily R Pfaff; Justin T Reese; Rose Relevo; Peter N Robinson; Joel H Saltz; Anthony Solomonides; Anupam Sule; Umit Topaloglu; Melissa A Haendel Journal: medRxiv Date: 2021-03-26