Seung Joo Kang1, Cheol Min Shin2, Joohon Sung3, Nayoung Kim2,4. 1. Department of Internal Medicine, Seoul National University Hospital Healthcare System Gangnam Center, Seoul, South Korea. 2. Department of Internal Medicine, Seoul National University Bundang Hospital, Seoungnam, Gyeonggi-do, Korea. 3. School of Public Health and Institute of Health and Environment, Seoul National University, Seoul, Korea. 4. Department of Internal Medicine and Liver Research Institute, Seoul National University College of Medicine, Seoul, Korea.
Abstract
BACKGROUND: Alcohol may increase gastric cancer risk. Alcohol can be more carcinogenic in persons who possess inactive ALDH2. The aim of this meta-analysis was to evaluate whether ALDH2 polymorphism can affect alcohol-induced gastric carcinogenesis. METHODS: We searched the PubMed, EMBASE, and Cochrane databases to identify relevant articles published between January 2000 and September 2019. Eligible articles were selected according to inclusion and exclusion criteria. The data were analyzed using Review Manager 5.3. RESULTS: A total of 7 case-control studies on ALDH2 rs671 polymorphism consisting of 3,251 gastric cancer cases and 4,943 controls were included in the analysis. Inactive ALDH2 genotypes (G/A or A/A) were associated with an increased risk of gastric cancer (odds ratio [OR] = 1.26, 95% confidence interval [CI]: 1.04-1.52, p = 0.02, I2 = 64%), compared with active ALDH2 (G/G genotype). Subgroup analysis by alcohol consumption showed that inactive ALDH2 increased risk for gastric cancer in moderate to heavy drinkers (OR = 1.85, 95% CI: 1.52-2.25, p < 0.01, I2 = 6%) more than in nondrinkers or mild drinkers (OR = 1.19; 95% CI: 1.05-1.36, p < 0.01, I2 = 6%). Moderate/heavy alcohol consumption increased gastric cancer risk in individuals with inactive ALDH2 (OR = 2.23, 95% CI: 1.63-3.05, p < 0.01, I2 = 30%) more than those with active ALDH2 (OR = 1.40, 95% CI: 0.98-2.01, p = 0.07, I2 = 85%). CONCLUSIONS: ALDH2 polymorphism can modify the risk of gastric cancer, especially in moderate/heavy drinkers. Gastric cancer is more susceptible among drinkers with inactive ALDH2. This article is protected by copyright. All rights reserved.
BACKGROUND:Alcohol may increase gastric cancer risk. Alcohol can be more carcinogenic in persons who possess inactive ALDH2. The aim of this meta-analysis was to evaluate whether ALDH2 polymorphism can affect alcohol-induced gastric carcinogenesis. METHODS: We searched the PubMed, EMBASE, and Cochrane databases to identify relevant articles published between January 2000 and September 2019. Eligible articles were selected according to inclusion and exclusion criteria. The data were analyzed using Review Manager 5.3. RESULTS: A total of 7 case-control studies on ALDH2rs671 polymorphism consisting of 3,251 gastric cancer cases and 4,943 controls were included in the analysis. Inactive ALDH2 genotypes (G/A or A/A) were associated with an increased risk of gastric cancer (odds ratio [OR] = 1.26, 95% confidence interval [CI]: 1.04-1.52, p = 0.02, I2 = 64%), compared with active ALDH2 (G/G genotype). Subgroup analysis by alcohol consumption showed that inactive ALDH2 increased risk for gastric cancer in moderate to heavy drinkers (OR = 1.85, 95% CI: 1.52-2.25, p < 0.01, I2 = 6%) more than in nondrinkers or mild drinkers (OR = 1.19; 95% CI: 1.05-1.36, p < 0.01, I2 = 6%). Moderate/heavy alcohol consumption increased gastric cancer risk in individuals with inactive ALDH2 (OR = 2.23, 95% CI: 1.63-3.05, p < 0.01, I2 = 30%) more than those with active ALDH2 (OR = 1.40, 95% CI: 0.98-2.01, p = 0.07, I2 = 85%). CONCLUSIONS:ALDH2 polymorphism can modify the risk of gastric cancer, especially in moderate/heavy drinkers. Gastric cancer is more susceptible among drinkers with inactive ALDH2. This article is protected by copyright. All rights reserved.
Authors: Pek Kei Im; Ling Yang; Christiana Kartsonaki; Yiping Chen; Yu Guo; Huaidong Du; Kuang Lin; Rene Kerosi; Alex Hacker; Jingchao Liu; Canqing Yu; Jun Lv; Robin G Walters; Liming Li; Zhengming Chen; Iona Y Millwood Journal: Int J Cancer Date: 2022-01-20 Impact factor: 7.316