Diego Santos-García1, Fonticoba T De Deus2, Bartolome C Cores1, Aymerich L Valdés1, Castro E Suárez2, Ángel Aneiros2, Silvia Jesús3,4, Miquel Aguilar5, Pau Pastor5, Lluís Planellas6, Marina Cosgaya6, Caldente J García7, Nuria Caballol8, Inés Legarda9, Vara J Hernández10, Iria Cabo11, Manzanares L López12, Aramburu I González4,13, Rivera M A Ávila14, Catalán M José15, Víctor Nogueira16, Víctor Puente17, Moreno J M García18, Carmen Borrué19, Vila B Solano20, Sauco M Álvarez21, Lydia Vela22, Sonia Escalante23, Esther Cubo24, Padilla F Carrillo25, Castrillo J C Martínez26, Alonso P Sánchez27, Losada M G Alonso28, Ariztegui N López29, Itziar Gastón30, Jaime Kulisevsky4,31, Estrada M Blázquez32, Manuel Seijo11, Martínez J Rúiz33, Caridad Valero34, Mónica Kurtis35, Oriol de Fábregues-Boixar10, Ardura J González36, Jurczynska C Prieto37, Díaz L López38, Darrian McAfee39, Pablo Mir3,4. 1. Complejo Hospitalario Universitario de A Coruña (CHUAC), A Coruña, Spain. 2. Complejo Hospitalario Universitario de Ferrol (CHUF), A Coruña, Spain. 3. Hospital Universitario Virgen del Rocío, Sevilla, Spain. 4. Centro de Investigación Biomédica en Red Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain. 5. Hospital Universitari Mutua de Terrassa, Terrassa, Barcelona, Spain. 6. Hospital Clínic de Barcelona, Barcelona, Spain. 7. Centro Neurológico Oms 42, Palma de Mallorca, Spain. 8. Consorci Sanitari Integral, Hospital Moisés Broggi, Sant Joan Despí, Barcelona, Spain. 9. Hospital Universitario Son Espases, Palma de Mallorca, Spain. 10. Hospital Universitario Vall d´Hebron, Barcelona, Spain. 11. Complejo Hospitalario Universitario de Pontevedra (CHOP), Pontevedra, Spain. 12. Hospital Universitario La Princesa, Madrid, Spain. 13. Hospital Universitario Marqués de Valdecilla, Santander, Spain. 14. Consorci Sanitari Integral, Hospital General de L´Hospitalet, Barcelona, Spain. 15. Hospital Universitario Clínico San Carlos, Madrid, Spain. 16. Hospital Da Costa, Burela, Lugo, Spain. 17. Hospital del Mar, Barcelona, Spain. 18. Hospital Universitario Virgen Macarena, Sevilla, Spain. 19. Hospital Infanta Sofía, Madrid, Spain. 20. Institut d'Assistència Sanitària (IAS) - Institut Català de la Salut, Girona, Spain. 21. Hospital General Universitario de Elche, Elche, Spain. 22. Fundación Hospital de Alcorcón, Madrid, Spain. 23. Hospital de Tortosa Verge de la Cinta (HTVC), Tortosa, Tarragona, Spain. 24. Complejo Asistencial Universitario de Burgos, Burgos, Spain. 25. Hospital Universitario de Canarias, San Cristóbal de la Laguna, Santa Cruz de Tenerife, Spain. 26. Hospital Universitario Ramón y Cajal, Madrid, Spain. 27. Hospital Universitario Puerta de Hierro, Madrid, Spain. 28. Hospital Álvaro Cunqueiro, Complejo Hospitalario Universitario de Vigo (CHUVI), Vigo, Spain. 29. Complejo Hospitalario de Toledo, Toledo, Spain. 30. Complejo Hospitalario de Navarra, Pamplona, Spain. 31. Hospital de Sant Pau, Barcelona, Spain. 32. Hospital Universitario Central de Asturias, Oviedo, Spain. 33. Hospital Universitario Donostia, San Sebastián, Spain. 34. Hospital Arnau de Vilanova, Valencia, Spain. 35. Hospital Ruber Internacional, Madrid, Spain. 36. Hospital Universitario Lucus Augusti (HULA), Lugo, Spain. 37. Hospital Rey Juan Carlos, Madrid, Spain. 38. Complejo Hospitalario Universitario de Orense (CHUO), Orense, Spain. 39. Department of Neurology, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Abstract
BACKGROUND: Although depression is known to be frequent in Parkinson's disease (PD), it is unclear how mood can change and/or impact on patient's quality of life (QoL) over time. Our aim was to analyze the frequency of depression, mood related factors and the contribution of mood to a patient's QoL perception in regard to disease duration. METHODS: PD patients recruited from the COPPADIS cohort from January 2016 to November 2017 were included in this cross-sectional study. Three groups were defined: <5 years (Group A); from 5 to <10 years (Group B); ≥10 years (Group C). Analysis with well-planned linear regression models was conducted to determine how different factors contribute to mood (Beck Depression Inventory-II [BDI-II] as dependent variable), to health-related QoL (39-item Parkinson's Disease Questionnaire [PDQ-39SI] as dependent variable) and to global QoL (European Health Interview Survey - Quality of Life Eight-Item Index [EUROHIS-QOL8] as dependent variable). RESULTS: Six hundred and sixty-three PD patients (62.6 ± 8.9 years old, 59.6% males) were included: Group A, 50.1% (n = 332); Group B, 33.3% (n = 221) and Group C, 16.6% (n = 110). There were no differences between the three groups in terms of the frequency of depressive symptoms nor the frequency of depression type (major vs. minor vs. subthreshold) (p = 0.729). However, the unique percent variance of PDQ-39SI and EUROHIS-QOL8 explained by BDI-II total score was 2 (23.7%) and threefold (26.9%), respectively, in Group C compared to the other two groups. EUROHIS-QOL8 total score provided the highest unique contribution to mood (16.8%). CONCLUSIONS: Although depression-type frequency does not appear to change over time in PD; the contribution of mood on QoL perception is greater in patients with longer disease duration.
BACKGROUND: Although depression is known to be frequent in Parkinson's disease (PD), it is unclear how mood can change and/or impact on patient's quality of life (QoL) over time. Our aim was to analyze the frequency of depression, mood related factors and the contribution of mood to a patient's QoL perception in regard to disease duration. METHODS:PDpatients recruited from the COPPADIS cohort from January 2016 to November 2017 were included in this cross-sectional study. Three groups were defined: <5 years (Group A); from 5 to <10 years (Group B); ≥10 years (Group C). Analysis with well-planned linear regression models was conducted to determine how different factors contribute to mood (Beck Depression Inventory-II [BDI-II] as dependent variable), to health-related QoL (39-item Parkinson's Disease Questionnaire [PDQ-39SI] as dependent variable) and to global QoL (European Health Interview Survey - Quality of Life Eight-Item Index [EUROHIS-QOL8] as dependent variable). RESULTS: Six hundred and sixty-three PDpatients (62.6 ± 8.9 years old, 59.6% males) were included: Group A, 50.1% (n = 332); Group B, 33.3% (n = 221) and Group C, 16.6% (n = 110). There were no differences between the three groups in terms of the frequency of depressive symptoms nor the frequency of depression type (major vs. minor vs. subthreshold) (p = 0.729). However, the unique percent variance of PDQ-39SI and EUROHIS-QOL8 explained by BDI-II total score was 2 (23.7%) and threefold (26.9%), respectively, in Group C compared to the other two groups. EUROHIS-QOL8 total score provided the highest unique contribution to mood (16.8%). CONCLUSIONS: Although depression-type frequency does not appear to change over time in PD; the contribution of mood on QoL perception is greater in patients with longer disease duration.
Authors: Carmen M Labandeira; Maria G Alonso Losada; Rosa Yáñez Baña; Maria I Cimas Hernando; Iria Cabo López; Jose M Paz González; Maria J Gonzalez Palmás; Cristina Martínez Miró; Diego Santos García Journal: Adv Ther Date: 2021-09-15 Impact factor: 3.845