Isa Ozbay1, Muhammet Fatih Topuz2, Fatih Oghan3, Havva Kocak4, Cuneyt Kucur5. 1. Department of Otolaryngology, Atasehir Avicenna Hospital, Istanbul, Turkey. 2. Department of Otolaryngology, Kutahya Saglık Bilimleri University, Kutahya, Turkey. 3. Department of Otolaryngology, Kutahya Saglık Bilimleri University, Kutahya, Turkey. fatih.oghan@ksbu.edu.tr. 4. Department of Biochemistry, Kutahya Saglık Bilimleri University, Kutahya, Turkey. 5. Department of Otolaryngology, Bezmi Alem Vakıf University, Istanbul, Turkey.
Abstract
PURPOSE: We aimed to evaluate oxidative stress in patients with peripheral vertigo by measuring serum prolidase, malondialdehyde (MDA) and catalase levels. METHODS: A total of 30 patients (age: 60 <) with peripheral vertigo and 30 healthy subjects were recruited. Blood samples were collected from both groups and serum prolidase levels were measured using enzyme-linked immunosorbent assay (ELISA). MDA and catalase levels were measured by the spectrophotometric method. RESULTS: The most common cause of vertigo was BPPV (53.3%), followed by Ménière's disease (16.6%), vestibular neuritis (13.3%), lateral semicircular canal fistula (3.3%), and idiopathic vertigo (13.3%). Mean serum prolidase activity and MDA levels were significantly higher in the vertigo patients than in the control subjects (P < 0.05); however, there was no statistically significant difference in mean serum catalase levels between the groups (P > 0.05). CONCLUSION: We concluded that serum prolidase and MDA levels may be used as markers of oxidative stress in patients with peripheral vertigo.
PURPOSE: We aimed to evaluate oxidative stress in patients with peripheral vertigo by measuring serum prolidase, malondialdehyde (MDA) and catalase levels. METHODS: A total of 30 patients (age: 60 <) with peripheral vertigo and 30 healthy subjects were recruited. Blood samples were collected from both groups and serum prolidase levels were measured using enzyme-linked immunosorbent assay (ELISA). MDA and catalase levels were measured by the spectrophotometric method. RESULTS: The most common cause of vertigo was BPPV (53.3%), followed by Ménière's disease (16.6%), vestibular neuritis (13.3%), lateral semicircular canal fistula (3.3%), and idiopathic vertigo (13.3%). Mean serum prolidase activity and MDA levels were significantly higher in the vertigo patients than in the control subjects (P < 0.05); however, there was no statistically significant difference in mean serum catalase levels between the groups (P > 0.05). CONCLUSION: We concluded that serum prolidase and MDA levels may be used as markers of oxidative stress in patients with peripheral vertigo.