AIMS: The aim of this study was to validate the tricuspid annular plane systolic excursion/systolic pulmonary artery (PA) pressure (TAPSE/PASP) ratio with the invasive pressure-volume (PV) loop-derived end-systolic right ventricular (RV) elastance/PA elastance (Ees/Ea) ratio in patients with heart failure with reduced ejection fraction (HFREF) and secondary pulmonary hypertension (PH). METHODS AND RESULTS: The relationship of TAPSE and TAPSE/PASP with RV-PV loop (single-beat)-derived contractility Ees, afterload Ea, and Ees/Ea was assessed in 110 patients with HFREF with and without secondary PH. The results were compared with other surrogate parameters such as the fractional area change/PASP ratio. The association of the surrogates with all-cause mortality was evaluated. In patients with PH (n = 74, 67%), TAPSE significantly correlated with Ees (r = 0.356), inverse with Ea (r = -0.514) but was most closely associated with Ees/Ea (r = 0.77). Placing TAPSE in a ratio with PASP slightly reduced the relationship to Ees/Ea (r = 0.71) but was more closely related to the parameters of PA vascular load, diastolic RV function, and RV energetics. The area under the curve of TAPSE/PASP and TAPSE for discriminating overall survival in receiver operating characteristic analysis was not different (P = 0.78. Prognostic relevant cut-offs were 17 mm for TAPSE and 0.38 mm/mmHg for TAPSE/PASP. Both parameters in multivariate cox regression remained independently prognostically relevant. CONCLUSION: TAPSE is an easily and reliably obtainable and valid surrogate parameter for RV-PA coupling in PH due to HFREF. Putting TAPSE into a ratio with PASP did not further improve the coupling information or prognostic assessment. TRIAL IDENTIFIER: DRKS-German Clinical Trials Register (DRKS00011133; https://www.drks.de/drks_web/navigate.do?navigationId=trial.HTML&TRIAL_ID=DRKS00011133). Published on behalf of the European Society of Cardiology. All rights reserved.
AIMS: The aim of this study was to validate the tricuspid annular plane systolic excursion/systolic pulmonary artery (PA) pressure (TAPSE/PASP) ratio with the invasive pressure-volume (PV) loop-derived end-systolic right ventricular (RV) elastance/PA elastance (Ees/Ea) ratio in patients with heart failure with reduced ejection fraction (HFREF) and secondary pulmonary hypertension (PH). METHODS AND RESULTS: The relationship of TAPSE and TAPSE/PASP with RV-PV loop (single-beat)-derived contractility Ees, afterload Ea, and Ees/Ea was assessed in 110 patients with HFREF with and without secondary PH. The results were compared with other surrogate parameters such as the fractional area change/PASP ratio. The association of the surrogates with all-cause mortality was evaluated. In patients with PH (n = 74, 67%), TAPSE significantly correlated with Ees (r = 0.356), inverse with Ea (r = -0.514) but was most closely associated with Ees/Ea (r = 0.77). Placing TAPSE in a ratio with PASP slightly reduced the relationship to Ees/Ea (r = 0.71) but was more closely related to the parameters of PA vascular load, diastolic RV function, and RV energetics. The area under the curve of TAPSE/PASP and TAPSE for discriminating overall survival in receiver operating characteristic analysis was not different (P = 0.78. Prognostic relevant cut-offs were 17 mm for TAPSE and 0.38 mm/mmHg for TAPSE/PASP. Both parameters in multivariate cox regression remained independently prognostically relevant. CONCLUSION: TAPSE is an easily and reliably obtainable and valid surrogate parameter for RV-PA coupling in PH due to HFREF. Putting TAPSE into a ratio with PASP did not further improve the coupling information or prognostic assessment. TRIAL IDENTIFIER: DRKS-German Clinical Trials Register (DRKS00011133; https://www.drks.de/drks_web/navigate.do?navigationId=trial.HTML&TRIAL_ID=DRKS00011133). Published on behalf of the European Society of Cardiology. All rights reserved.
Authors: Olga Vriz; Gruschen Veldman; Luna Gargani; Francesco Ferrara; Paolo Frumento; Michele D'Alto; Antonello D'Andrea; Sarah Aldosari Radaan; Rosangela Cocchia; Alberto Maria Marra; Brigida Ranieri; Andrea Salzano; Anna Agnese Stanziola; Damien Voilliot; Gergely Agoston; Filippo Cademartiri; Antonio Cittadini; Jaroslaw D Kasprzak; Ekkehard Grünig; Francesco Bandera; Marco Guazzi; Lawrence Rudski; Eduardo Bossone Journal: Int J Cardiovasc Imaging Date: 2021-07-05 Impact factor: 2.357
Authors: Michael I Brener; Amirali Masoumi; Vivian G Ng; Khodr Tello; Marcelo B Bastos; William K Cornwell; Steven Hsu; Ryan J Tedford; Philipp Lurz; Karl-Philipp Rommel; Karl-Patrik Kresoja; Sherif F Nagueh; Manreet K Kanwar; Navin K Kapur; Gurumurthy Hiremath; Mohammad Sarraf; Antoon J M Van Den Enden; Nicolas M Van Mieghem; Paul M Heerdt; Rebecca T Hahn; Susheel K Kodali; Gabriel T Sayer; Nir Uriel; Daniel Burkhoff Journal: Circ Heart Fail Date: 2021-12-29 Impact factor: 8.790
Authors: Pascal Bauer; Khodr Tello; Lutz Kraushaar; Oliver Dörr; Stanislav Keranov; Faeq Husain-Syed; Holger Nef; Christian W Hamm; Astrid Most Journal: Clin Res Cardiol Date: 2022-09-14 Impact factor: 6.138
Authors: Fawaz Alenezi; Taylor A Covington; Monica Mukherjee; Stephen C Mathai; Paul B Yu; Sudarshan Rajagopal Journal: Circ Res Date: 2022-04-28 Impact factor: 23.213
Authors: Alexander Schmeißer; Thomas Rauwolf; Thomas Groscheck; Katharina Fischbach; Siegfried Kropf; Blerim Luani; Ivan Tanev; Michael Hansen; Saskia Meißler; Kerstin Schäfer; Paul Steendijk; Ruediger C Braun-Dullaeus Journal: ESC Heart Fail Date: 2021-05-02
Authors: Stanislav Keranov; Saskia Haen; Julia Vietheer; Wiebke Rutsatz; Jan-Sebastian Wolter; Steffen D Kriechbaum; Beatrice von Jeinsen; Pascal Bauer; Khodr Tello; Manuel Richter; Oliver Dörr; Andreas J Rieth; Holger Nef; Christian W Hamm; Christoph Liebetrau; Andreas Rolf; Till Keller Journal: Diagnostics (Basel) Date: 2021-11-24
Authors: Olga Vriz; Paolo Palatini; Lawrence Rudski; Paolo Frumento; Jarosław D Kasprzak; Francesco Ferrara; Rosangela Cocchia; Luna Gargani; Karina Wierzbowska-Drabik; Valentina Capone; Brigida Ranieri; Andrea Salzano; Anna Agnese Stanziola; Alberto Maria Marra; Roberto Annunziata; Salvatore Chianese; Salvatore Rega; Teresa Saltalamacchia; Renato Maramaldi; Chiara Sepe; Giuseppe Limongelli; Filippo Cademartiri; Antonello D'Andrea; Michele D'Alto; Raffaele Izzo; Nicola Ferrara; Ciro Mauro; Antonio Cittadini; Grünig Ekkehard; Marco Guazzi; Eduardo Bossone Journal: J Clin Med Date: 2022-01-17 Impact factor: 4.241