Stephen G Chun1, Charles B Simone2, Arya Amini3, Indrin J Chetty4, Jessica Donington5, Martin J Edelman6, Kristin A Higgins7, Larry L Kestin8, Benjamin Movsas4, George B Rodrigues9, Kenneth E Rosenzweig10, Ben J Slotman11, Igor I Rybkin12, Andrea Wolf13, Joe Y Chang14. 1. Department of Radiation Oncology, The University of Texas, MD Anderson Cancer Center, Houston, Texas. Electronic address: sgchun@mdanderson.org. 2. New York Proton Center, New York, New York. 3. Department of Radiation Oncology, City of Hope Comprehensive Cancer Center, Duarte, California. 4. Department of Radiation Oncology, Henry Ford Cancer Institute, Detroit, Michigan. 5. Department of Surgery, The University of Chicago, Chicago, Illinois. 6. Department of Hematology and Oncology, Fox Chase Comprehensive Cancer Center, Philadelphia, Pennsylvania. 7. Department of Radiation Oncology, Emory University Winship Cancer Institute, Atlanta, Georgia. 8. MHP Radiation Oncology Institute/GenesisCare USA, Farmington Hills, Michigan. 9. Department of Radiation Oncology, London Health Sciences Centre, London, Ontario, Canada. 10. Department of Radiation Oncology, Mount Sinai School of Medicine, New York, New York. 11. Department of Radiation Oncology, Amsterdam University Medical Center, Amsterdam, The Netherlands. 12. Department of Hematology and Oncology, Henry Ford Cancer Institute, Detroit, Michigan. 13. Department of Thoracic Surgery, Mount Sinai School of Medicine, New York, New York. 14. Department of Radiation Oncology, The University of Texas, MD Anderson Cancer Center, Houston, Texas.
Abstract
INTRODUCTION: Combined modality therapy with concurrent chemotherapy and radiation has long been the standard of care for limited-stage SCLC (LS-SCLC). However, there is controversy over best combined modality practices for LS-SCLC. To address these controversies, the American Radium Society (ARS) Thoracic Appropriate Use Criteria (AUC) Committee have developed updated consensus guidelines for the treatment of LS-SCLC. METHODS: The ARS AUC are evidence-based guidelines for specific clinical conditions that are reviewed by a multidisciplinary expert panel. The guidelines include a review and analysis of current evidence with application of consensus methodology (modified Delphi) to rate the appropriateness of treatments recommended by the panel for LS-SCLC. Agreement or consensus was defined as less than or equal to 3 rating points from the panel median. The consensus ratings and recommendations were then vetted by the ARS Executive Committee and subject to public comment before finalization. RESULTS: The ARS Thoracic AUC committee developed multiple consensus recommendations for LS-SCLC. There was strong consensus that patients with unresectable LS-SCLC should receive concurrent chemotherapy with radiation delivered either once or twice daily. For medically inoperable T1-T2N0 LS-SCLC, either concurrent chemoradiation or stereotactic body radiation followed by adjuvant chemotherapy is a reasonable treatment option. The panel continues to recommend whole-brain prophylactic cranial irradiation after response to chemoradiation for LS-SCLC. There was panel agreement that prophylactic cranial irradiation with hippocampal avoidance and programmed cell death protein-1/programmed death-ligand 1-directed immune therapy should not be routinely administered outside the context of clinical trials at this time. CONCLUSIONS: The ARS Thoracic AUC Committee provide consensus recommendations for LS-SCLC that aim to provide a groundwork for multidisciplinary care and clinical trials.
INTRODUCTION: Combined modality therapy with concurrent chemotherapy and radiation has long been the standard of care for limited-stage SCLC (LS-SCLC). However, there is controversy over best combined modality practices for LS-SCLC. To address these controversies, the American Radium Society (ARS) Thoracic Appropriate Use Criteria (AUC) Committee have developed updated consensus guidelines for the treatment of LS-SCLC. METHODS: The ARS AUC are evidence-based guidelines for specific clinical conditions that are reviewed by a multidisciplinary expert panel. The guidelines include a review and analysis of current evidence with application of consensus methodology (modified Delphi) to rate the appropriateness of treatments recommended by the panel for LS-SCLC. Agreement or consensus was defined as less than or equal to 3 rating points from the panel median. The consensus ratings and recommendations were then vetted by the ARS Executive Committee and subject to public comment before finalization. RESULTS: The ARS Thoracic AUC committee developed multiple consensus recommendations for LS-SCLC. There was strong consensus that patients with unresectable LS-SCLC should receive concurrent chemotherapy with radiation delivered either once or twice daily. For medically inoperable T1-T2N0 LS-SCLC, either concurrent chemoradiation or stereotactic body radiation followed by adjuvant chemotherapy is a reasonable treatment option. The panel continues to recommend whole-brain prophylactic cranial irradiation after response to chemoradiation for LS-SCLC. There was panel agreement that prophylactic cranial irradiation with hippocampal avoidance and programmed cell death protein-1/programmed death-ligand 1-directed immune therapy should not be routinely administered outside the context of clinical trials at this time. CONCLUSIONS: The ARS Thoracic AUC Committee provide consensus recommendations for LS-SCLC that aim to provide a groundwork for multidisciplinary care and clinical trials.
Authors: Nadia A Saeed; Lan Jin; Alexander W Sasse; Arya Amini; Vivek Verma; Nataniel H Lester-Coll; Po-Han Chen; Roy H Decker; Henry S Park Journal: J Thorac Dis Date: 2022-02 Impact factor: 2.895