OBJECTIVES: To investigate the relationship between amyloid-β- and tau-based Alzheimer's disease (AD) pathologies assessed using positron emission tomography imaging and neuropsychiatric symptoms (NPS) in a sample of AD continuum including clinically normal subjects and patients with mild cognitive impairment or AD. METHODS: We analyzed datasets of the Alzheimer's disease Neuroimaging Initiative and included amyloid-positive subjects who underwent an AV-45 scan within 1 year of an AV-1451 scan (n = 99). Correlation between standardized uptake value ratio (SUVR) of AV-45 and AV-1451 and the Neuropsychiatric Inventory (NPI) score (and its four domain subscores for hyperactivity, psychosis, affective, and apathy) was evaluated. Stepwise logistic regression analysis was used to examine the influence of SUVRs on the presence of NPS. SUVRs were also tested for their ability to discriminate the group with NPS using receiver operating characteristic (ROC) curve analyses. RESULTS: Significant positive relationships were found between the total NPI score and affective symptoms and Braak 1&2 (transentorhinal region) AV-1451 SUVR. Stepwise logistic regression analysis identified tau accumulation in the area of Braak 1&2 as a significant covariate discriminating the presence of affective symptoms. The area under the ROC curve analysis showed that subjects with affective symptoms were discriminated by AV-1451 SUVR with an accuracy of 77.7%. CONCLUSIONS: Tau aggregation in the transentorhinal region, where neurodegeneration affected by tau pathology was seen in the early stage of AD, correlated with more severe NPS, especially affective symptoms. Therefore, tau pathology in the transentorhinal cortex might be associated with affective symptoms in the early stage of AD.
OBJECTIVES: To investigate the relationship between amyloid-β- and tau-based Alzheimer's disease (AD) pathologies assessed using positron emission tomography imaging and neuropsychiatric symptoms (NPS) in a sample of AD continuum including clinically normal subjects and patients with mild cognitive impairment or AD. METHODS: We analyzed datasets of the Alzheimer's disease Neuroimaging Initiative and included amyloid-positive subjects who underwent an AV-45 scan within 1 year of an AV-1451 scan (n = 99). Correlation between standardized uptake value ratio (SUVR) of AV-45 and AV-1451 and the Neuropsychiatric Inventory (NPI) score (and its four domain subscores for hyperactivity, psychosis, affective, and apathy) was evaluated. Stepwise logistic regression analysis was used to examine the influence of SUVRs on the presence of NPS. SUVRs were also tested for their ability to discriminate the group with NPS using receiver operating characteristic (ROC) curve analyses. RESULTS: Significant positive relationships were found between the total NPI score and affective symptoms and Braak 1&2 (transentorhinal region) AV-1451 SUVR. Stepwise logistic regression analysis identified tau accumulation in the area of Braak 1&2 as a significant covariate discriminating the presence of affective symptoms. The area under the ROC curve analysis showed that subjects with affective symptoms were discriminated by AV-1451 SUVR with an accuracy of 77.7%. CONCLUSIONS: Tau aggregation in the transentorhinal region, where neurodegeneration affected by tau pathology was seen in the early stage of AD, correlated with more severe NPS, especially affective symptoms. Therefore, tau pathology in the transentorhinal cortex might be associated with affective symptoms in the early stage of AD.
Authors: Bruno Dubois; Howard H Feldman; Claudia Jacova; Steven T Dekosky; Pascale Barberger-Gateau; Jeffrey Cummings; André Delacourte; Douglas Galasko; Serge Gauthier; Gregory Jicha; Kenichi Meguro; John O'brien; Florence Pasquier; Philippe Robert; Martin Rossor; Steven Salloway; Yaakov Stern; Pieter J Visser; Philip Scheltens Journal: Lancet Neurol Date: 2007-08 Impact factor: 44.182
Authors: Ganesh M Babulal; Nupur Ghoshal; Denise Head; Elizabeth K Vernon; David M Holtzman; Tammie L S Benzinger; Anne M Fagan; John C Morris; Catherine M Roe Journal: Am J Geriatr Psychiatry Date: 2016-04-19 Impact factor: 4.105
Authors: Yonas E Geda; Lon S Schneider; Laura N Gitlin; David S Miller; Gwenn S Smith; Joanne Bell; Jovier Evans; Michael Lee; Anton Porsteinsson; Krista L Lanctôt; Paul B Rosenberg; David L Sultzer; Paul T Francis; Henry Brodaty; Prasad P Padala; Chiadikaobi U Onyike; Luis Agüera Ortiz; Sonia Ancoli-Israel; Donald L Bliwise; Jennifer L Martin; Michael V Vitiello; Kristine Yaffe; Phyllis C Zee; Nathan Herrmann; Robert A Sweet; Clive Ballard; Ni A Khin; Cara Alfaro; Patrick S Murray; Susan Schultz; Constantine G Lyketsos Journal: Alzheimers Dement Date: 2013-04-03 Impact factor: 21.566
Authors: Yonas E Geda; Rosebud O Roberts; Michelle M Mielke; David S Knopman; Teresa J H Christianson; Vernon S Pankratz; Bradley F Boeve; Ondrej Sochor; Eric G Tangalos; Ronald C Petersen; Walter A Rocca Journal: Am J Psychiatry Date: 2014-05 Impact factor: 18.112