Grenye O'Malley1, Osagie Ebekozien2, Marisa Desimone3, Catherina T Pinnaro4, Alissa Roberts5, Sarit Polsky6, Nudrat Noor2, Grazia Aleppo7, Marina Basina8, Michael Tansey4, Devin Steenkamp9, Francesco Vendrame10, Ilona Lorincz11, Priyanka Mathias12, Shivani Agarwal12, Lauren Golden13, Irl B Hirsch14, Carol J Levy1. 1. Department of Endocrinology, Diabetes and Bone Diseases, Icahn School of Medicine, New York, New York. 2. T1D Exchange, Boston, Massachusetts. 3. Division of Endocrinology, Diabetes and Metabolism, SUNY Upstate Medical University, Syracuse, New York. 4. Stead Family Department of Pediatrics, University of Iowa, Iowa City, Iowa. 5. Department of Pediatrics, University of Washington, Seattle, Washington. 6. Barbara Davis Center for Diabetes, University of Colorado Anschutz Medical Campus, Aurora, Colorado. 7. Feinberg School of Medicine, Northwestern University, Chicago, Illinois. 8. Stanford University School of Medicine, Stanford, California. 9. Boston University School of Medicine and Boston Medical Center, Boston, Massachusetts. 10. Division of Endocrinology, Diabetes, and Metabolism, University of Miami, Miami, Florida. 11. Department of Endocrinology, Diabetes, and Metabolism, Hospital of University of Pennsylvania, Philadelphia, Pennsylvania. 12. Fleischer Institute for Diabetes and Metabolism, NY-Regional Center for Diabetes and Translational Research, Albert Einstein College of Medicine, New York, New York. 13. NYU Langone Medical Center, New York, New York. 14. University of Washington School of Medicine, Seattle, Washington.
Abstract
CONTEXT: Diabetes mellitus is associated with increased COVID-19 morbidity and mortality, but there are few data focusing on outcomes in people with type 1 diabetes. OBJECTIVE: The objective of this study was to analyze characteristics of adults with type 1 diabetes for associations with COVID-19 hospitalization. DESIGN: An observational multisite cross-sectional study was performed. Diabetes care providers answered a 33-item questionnaire regarding demographics, symptoms, and diabetes- and COVID-19-related care and outcomes. Descriptive statistics were used to describe the study population, and multivariate logistic regression models were used to analyze the relationship between glycated hemoglobin (HbA1c), age, and comorbidities and hospitalization. SETTING: Cases were submitted from 52 US sites between March and August 2020. PATIENTS OR OTHER PARTICIPANTS: Adults over the age of 19 with type 1 diabetes and confirmed COVID-19 infection were included. INTERVENTIONS: None. MAIN OUTCOME MEASURES: Hospitalization for COVID-19 infection. RESULTS: A total of 113 cases were analyzed. Fifty-eight patients were hospitalized, and 5 patients died. Patients who were hospitalized were more likely to be older, to identify as non-Hispanic Black, to use public insurance, or to have hypertension, and less likely to use continuous glucose monitoring or insulin pumps. Median HbA1c was 8.6% (70 mmol/mol) and was positively associated with hospitalization (odds ratio 1.42, 95% confidence interval 1.18-1.76), which persisted after adjustment for age, sex, race, and obesity. CONCLUSIONS: Baseline glycemic control and access to care are important modifiable risk factors which need to be addressed to optimize care of people with type 1 diabetes during the worldwide COVID-19 pandemic.
CONTEXT: Diabetes mellitus is associated with increased COVID-19 morbidity and mortality, but there are few data focusing on outcomes in people with type 1 diabetes. OBJECTIVE: The objective of this study was to analyze characteristics of adults with type 1 diabetes for associations with COVID-19 hospitalization. DESIGN: An observational multisite cross-sectional study was performed. Diabetes care providers answered a 33-item questionnaire regarding demographics, symptoms, and diabetes- and COVID-19-related care and outcomes. Descriptive statistics were used to describe the study population, and multivariate logistic regression models were used to analyze the relationship between glycated hemoglobin (HbA1c), age, and comorbidities and hospitalization. SETTING: Cases were submitted from 52 US sites between March and August 2020. PATIENTS OR OTHER PARTICIPANTS: Adults over the age of 19 with type 1 diabetes and confirmed COVID-19infection were included. INTERVENTIONS: None. MAIN OUTCOME MEASURES: Hospitalization for COVID-19infection. RESULTS: A total of 113 cases were analyzed. Fifty-eight patients were hospitalized, and 5 patientsdied. Patients who were hospitalized were more likely to be older, to identify as non-Hispanic Black, to use public insurance, or to have hypertension, and less likely to use continuous glucose monitoring or insulin pumps. Median HbA1c was 8.6% (70 mmol/mol) and was positively associated with hospitalization (odds ratio 1.42, 95% confidence interval 1.18-1.76), which persisted after adjustment for age, sex, race, and obesity. CONCLUSIONS: Baseline glycemic control and access to care are important modifiable risk factors which need to be addressed to optimize care of people with type 1 diabetes during the worldwide COVID-19 pandemic.
Authors: Andrew R Lavik; Osagie Ebekozien; Nudrat Noor; G Todd Alonso; Sarit Polsky; Scott M Blackman; Justin Chen; Sarah D Corathers; Carla Demeterco-Berggren; Mary Pat Gallagher; Margaret Greenfield; Ashley Garrity; Saketh Rompicherla; Robert Rapaport; Nana-Hawa Yayah Jones Journal: J Clin Endocrinol Metab Date: 2022-06-16 Impact factor: 6.134
Authors: Osagie Ebekozien; Ann Mungmode; Don Buckingham; Margaret Greenfield; Rashida Talib; Devin Steenkamp; J Sonya Haw; Ori Odugbesan; Michael Harris; Priyanka Mathias; Jane K Dickinson; Shivani Agarwal Journal: Diabetes Spectr Date: 2022-08-15