Tong Yang1,2, Hualou Wang1,2, Ying Xiong3, Chong Chen4,5,6,7, Keran Duan8, Jingya Jia1,2, Fei Ma1,2. 1. Department of Epidemiology and Biostatistics, School of Public Health, Tianjin Medical University, Tianjin, China. 2. Tianjin Key Laboratory of Environment, Nutrition and Public Health, Center for International Collaborative Research on environment, Nutrition and Public Health, Tianjin, China. 3. Department of Community Service, Wangdingdi Hospital of Tianjin Nankai District, Tianjin, China. 4. Department of Clinical Laboratory, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin, China. 5. Key Laboratory of Cancer Prevention and Therapy, Tianjin, China. 6. Tianjin's Clinical Research Center for Cancer, Tianjin, China. 7. National Human Genetic Resources Sharing Service Platform, Tianjin, China. 8. Biobank, Tianjin First Center Hospital, Tianjin, China.
Abstract
BACKGROUND:Cognitive decline in older adults is a serious public health problem today. Association between vitamin D supplementation and cognition remains controversial. OBJECTIVE: To determine whether a 12-month vitamin D supplementation improves cognitive function in elderly subjects with mild cognitive impairment (MCI), and whether it is mediated through the mechanism in which telomere length (TL) regulate oxidative stress. METHODS: This was a double-blind, randomized, placebo-controlled trial in Tianjin, China. Participants were all native Chinese speakers aged 65 years and older with MCI. 183 subjects were randomized to an intervention group (vitamin D 800 IU/day, n = 93) or a placebo group (the matching starch granules, n = 90), and followed up for 12 months. Tests of cognitive function and mechanism-related biomarkers were evaluated at baseline, 6 months, and 12 months. RESULTS: Repeated-measures ANOVA showed substantial improvements in the full scale intelligence quotient (FSIQ), information, digit span, vocabulary, block design, and picture arrangement scores in the vitamin D group over the placebo group (p < 0.001). Leukocyte TL was significantly higher, while serum 8-OXO-dG, OGG1mRNA, and P16INK4amRNA revealed greater decreases in the vitamin D group over the placebo group (p < 0.001). According to mixed-model repeated-measures ANOVA analysis, vitamin D group showed a significant enhancement in the FSIQ score for 12 months compared with the control (estimate value = 5.132, p < 0.001). CONCLUSION:Vitamin D supplementation for 12 months appears to improve cognitive function through reducing oxidative stress regulated by increased TL in order adults with MCI. Vitamin D may be a promising public health strategy to prevent cognitive decline.
RCT Entities:
BACKGROUND:Cognitive decline in older adults is a serious public health problem today. Association between vitamin D supplementation and cognition remains controversial. OBJECTIVE: To determine whether a 12-month vitamin D supplementation improves cognitive function in elderly subjects with mild cognitive impairment (MCI), and whether it is mediated through the mechanism in which telomere length (TL) regulate oxidative stress. METHODS: This was a double-blind, randomized, placebo-controlled trial in Tianjin, China. Participants were all native Chinese speakers aged 65 years and older with MCI. 183 subjects were randomized to an intervention group (vitamin D 800 IU/day, n = 93) or a placebo group (the matching starch granules, n = 90), and followed up for 12 months. Tests of cognitive function and mechanism-related biomarkers were evaluated at baseline, 6 months, and 12 months. RESULTS: Repeated-measures ANOVA showed substantial improvements in the full scale intelligence quotient (FSIQ), information, digit span, vocabulary, block design, and picture arrangement scores in the vitamin D group over the placebo group (p < 0.001). Leukocyte TL was significantly higher, while serum 8-OXO-dG, OGG1mRNA, and P16INK4amRNA revealed greater decreases in the vitamin D group over the placebo group (p < 0.001). According to mixed-model repeated-measures ANOVA analysis, vitamin D group showed a significant enhancement in the FSIQ score for 12 months compared with the control (estimate value = 5.132, p < 0.001). CONCLUSION:Vitamin D supplementation for 12 months appears to improve cognitive function through reducing oxidative stress regulated by increased TL in order adults with MCI. Vitamin D may be a promising public health strategy to prevent cognitive decline.
Entities:
Keywords:
Cognitive performance; oxidative stress; telomere; vitamin D
Authors: Rajalakshmi R; Chinnappa A Uthaiah; Ramya C M; SubbaRao V Madhunapantula; Paramahans V Salimath; Praveen K; Srinath K M; Kishor M R Journal: PLoS One Date: 2022-06-16 Impact factor: 3.752
Authors: Olga V Zimnitskaya; Marina M Petrova; Natalia V Lareva; Marina S Cherniaeva; Mustafa Al-Zamil; Anastasia E Ivanova; Natalia A Shnayder Journal: Genes (Basel) Date: 2022-07-12 Impact factor: 4.141