F Franconieri1, O Join-Lambert2, C Creveuil3, M Auzou4, F Labombarda5, A Aouba6, R Verdon7, A de La Blanchardière8. 1. Department of Infectious and Tropical Diseases, Normandie Univ, UNICAEN, CHU de Caen Normandie, 14000 Caen, France. 2. Laboratory of Microbiology, Normandie Univ, UNICAEN, CHU de Caen Normandie, 14000 Caen, France; Research Group on Microbial Adaptation, Normandie Univ, UNICAEN, EA2656, GRAM 2.0, 14000 Caen, France. 3. Biostatistics and Clinical Research Unit, Normandie Univ, UNICAEN, CHU de Caen Normandie, 14000 Caen, France. 4. Laboratory of Microbiology, Normandie Univ, UNICAEN, CHU de Caen Normandie, 14000 Caen, France. 5. Department of Cardiology, Normandie Univ, UNICAEN, CHU de Caen Normandie, 14000 Caen, France. 6. Department of Internal Medicine, Normandie Univ, UNICAEN, CHU de Caen Normandie, 14000 Caen, France. 7. Department of Infectious and Tropical Diseases, Normandie Univ, UNICAEN, CHU de Caen Normandie, 14000 Caen, France; Research Group on Microbial Adaptation, Normandie Univ, UNICAEN, EA2656, GRAM 2.0, 14000 Caen, France. 8. Department of Infectious and Tropical Diseases, Normandie Univ, UNICAEN, CHU de Caen Normandie, 14000 Caen, France. Electronic address: delablanchardiere-a@chu-caen.fr.
Abstract
OBJECTIVE: To describe the epidemiological, clinical, microbiological, and therapeutic features and outcomes of Rothia infective endocarditis (RIE) and extracardiac infections (ECRI). METHODS: We performed a systematic literature review of published cases of RIE and ECRI. RESULTS: After inclusion of a personal case report, 51 cases of RIE and 215 cases of ECRI were reported. Compared with ECRI patients, RIE patients were significantly more often males (80% versus 59%), intravenous drug users (IVDU) (20% versus 3%), immunocompetent (76% versus 31%), and infected with R. dentocariosa (55% versus 13%) but lacked significant differences with regard to median age (45 years [6-79]), rate of orodental abnormalities (33%), and six-month mortality (14%). Following microbiological documentation, RIE was most often treated with a beta-lactam antibiotic alone (39%) for a median duration of six weeks and required surgery in 39% of cases. CONCLUSION: RIE is rare and likely secondary to a dental portal of entry or cutaneous inoculation in IVDU. Its prognosis seems to be favorable.
OBJECTIVE: To describe the epidemiological, clinical, microbiological, and therapeutic features and outcomes of Rothia infective endocarditis (RIE) and extracardiac infections (ECRI). METHODS: We performed a systematic literature review of published cases of RIE and ECRI. RESULTS: After inclusion of a personal case report, 51 cases of RIE and 215 cases of ECRI were reported. Compared with ECRI patients, RIE patients were significantly more often males (80% versus 59%), intravenous drug users (IVDU) (20% versus 3%), immunocompetent (76% versus 31%), and infected with R. dentocariosa (55% versus 13%) but lacked significant differences with regard to median age (45 years [6-79]), rate of orodental abnormalities (33%), and six-month mortality (14%). Following microbiological documentation, RIE was most often treated with a beta-lactam antibiotic alone (39%) for a median duration of six weeks and required surgery in 39% of cases. CONCLUSION: RIE is rare and likely secondary to a dental portal of entry or cutaneous inoculation in IVDU. Its prognosis seems to be favorable.