Dandan Hu1, Zhibo Xie2, Yuqian Ye2, Suhad Bahijri3,4, Minshan Chen1. 1. Department of Liver Surgery, Sun Yat-Sen University Cancer Center, Guangzhou, China. 2. Department of Surgery, Peking Union Medical College Hospital, Beijing, China. 3. Department of Clinical Biochemistry, Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia. 4. Saudi Diabetes Study Research Group (SDRG)-King Fahd Medical Research Centre, King Abdulaziz University, Jeddah, Saudi Arabia.
Abstract
IMPORTANCE: There is accumulating evidence that intermittent fasting (IF) is connected to improved health condition and longevity time-restricted feeding (TRF) is the most recognized and extensively studied model of IF. OBJECTIVE: To investigate the underlying mechanism of pleiotropic benefits of IF and hint the most advantageous feeding pattern for humans. EVIDENCE REVIEW: We searched MEDLINE, EMBASE, Cochrane Library and Google Scholar by 2020 April for publications on IF or TRF and their mechanisms. Studies include animal models and human cohorts. FINDINGS: One important mechanism is that IF allows certain period of fasting time, in which our bodies activate pathways of repair and rejuvenation. Moreover, the advantages of IF, especially TRF over total caloric restriction (CR) provided bases for various animal and human studies which suggested that the feeding-fasting rhythm stimulates the fluctuation of our gut microbiota and a series of subsequent molecular alterations, which in turn restored a healthier circadian clock that resembled our inherent clock formed throughout millions of years of homo sapiens history. CONCLUSIONS AND RELEVANCE FOR REVIEWS: Complete understanding of the mechanism leading to the beneficial effects of IF paves the way for tailored dietary regimen to combat a wide range of diseases and ill health conditions. 2020 Hepatobiliary Surgery and Nutrition. All rights reserved.
IMPORTANCE: There is accumulating evidence that intermittent fasting (IF) is connected to improved health condition and longevity time-restricted feeding (TRF) is the most recognized and extensively studied model of IF. OBJECTIVE: To investigate the underlying mechanism of pleiotropic benefits of IF and hint the most advantageous feeding pattern for humans. EVIDENCE REVIEW: We searched MEDLINE, EMBASE, Cochrane Library and Google Scholar by 2020 April for publications on IF or TRF and their mechanisms. Studies include animal models and human cohorts. FINDINGS: One important mechanism is that IF allows certain period of fasting time, in which our bodies activate pathways of repair and rejuvenation. Moreover, the advantages of IF, especially TRF over total caloric restriction (CR) provided bases for various animal and human studies which suggested that the feeding-fasting rhythm stimulates the fluctuation of our gut microbiota and a series of subsequent molecular alterations, which in turn restored a healthier circadian clock that resembled our inherent clock formed throughout millions of years of homo sapiens history. CONCLUSIONS AND RELEVANCE FOR REVIEWS: Complete understanding of the mechanism leading to the beneficial effects of IF paves the way for tailored dietary regimen to combat a wide range of diseases and ill health conditions. 2020 Hepatobiliary Surgery and Nutrition. All rights reserved.
Entities:
Keywords:
Intermittent fasting (IF); circadian rhythm; gut microbiota
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