A study of low birth weight prevalence and risk factors among newborns in a public-hospital at Kilis, Turkey.

BACKGROUND: Low birth weight (LBW) is an important indicator of reproductive health and general health status of population.
OBJECTIVES: The present study was aimed to estimate the prevalence of low birth weight (LBW), and to investigate the associations between some risk factors and LBW in Syrian refugee and Turkish population in Kilis, Turkey.
METHODS: The population of this study constituted of a total of 4379 infants born in Kilis State Hospital in 2016 using a retrospective cross-sectional study design. The data were collected from birth records. The data were analyzed using SPSS version 16.0. Binary logistic regression analysis was performed to identify predictors of low birth weight. Factors with a p-value < 0.05 were deemed to be statistically significant.
RESULTS: The prevalence of LBW was 6.7% in all groups. Significant relationships were found between young maternal age, Syrian refugee mother, female infants, cesarean delivery and LBW.
CONCLUSION: The prevalence of low birth weight in the study area was comparatively lower than that of countrywide figure. Maternal related variables like, maternal age, mother's nationality, and mode of birth (vaginal, cesarean) take after up as well as new-born related variables like gender of the neonate were significantly related with low birth weight.

Introduction

Low birth weight (LBW) continues to remain a major public health problem worldwide, especially in the developing countries. The birth weight of an infant is the single most important determinant of its chances of survival, healthy growth, and development[1]. World Health Organization (WHO) defines the low birth weight as weight at birth of less than 2,500 grams (5.5 pounds). According to the epidemiological observations, infants weighing less than 2,500 g are approximately 20 times more likely to die than heavier infants[2]. More than 20 million infants worldwide, representing 15.5 percent of all births are born with low birth weight, 95.6 percent of them in developing countries. The level of low birth weight in developing countries (16.5 percent) is more than double in comparison with the level in developed regions (7 percent)[2]. According to the Turkey Demographic and Health Survey report, 10 percent of the births in the last five years prior to 2013 are of LBW (less than 2,500 g). In the Southeastern Anatolia Region, 13.5% of the infants are reported to be LBW. It was documented that the ratio of LBW infants is lowest in Western Anatolia Region (7.6%) and highest in Northeast Anatolia Region (17.7%)[3].

Many and various studies have been performed in order to identify reasons of LBW, documenting that the factors fall into a diversity of socioeconomic, biological, psychological and nutrition-related factors. A number of studies have shown correlates of teenage mother, low maternal weight and height, low maternal education, low calorie intake, maternal anemia, poor antenatal care, maternal smoking, hypertension during pregnancy, hard maternal physical work, genetic syndromes, maternal exposure to toxic substances, pregnancy-induced medical ailments, parity, inter pregnancy interval, and bad obstetric history with occurrence of low birth weight infants[4,5,6,7]. The maternal risk factors are biologically and socially interrelated but most of them are variable. We should highlight that all factors might be present in a population at a certain time or interval. The mortality of LBW can be alleviated with the identification of the predominant maternal risk factors in a particular area responsible for LBW1.

According to the Turkish Interior Ministry's Directorate General of Migration Management's 2016 year statistics, there are a total of 2,834,441 registered Syrian migrants in Turkey, corresponding to 3.55 percent of the Turkish population of 79,814,871. The directorate reported a total of 122,327 Syrians are currently living in the border province of Kilis (ratio to provincial population: 93.50%), which has a native population of just 130,825[8]. Refugees are a unique subset of migrants who are at increased risk of adverse health outcomes. During pregnancy, refugee women may be exposed to violence, poor health and nutrition, homelessness, and limited access to health care resources[9]. In order to prevent LBW, the predominant risk factors regarding with the LBW are needed to be understood and clarified. Additionally, the interrelationships between maternal, social and cultural factors need to be investigated[10]. In this context, the results obtained along with the present study might be essential to reveal interventions aimed at altering behaviors and other risk variables for low birth weight.

The present study was aimed to estimate the prevalence of low birth weight (LBW), and to investigate the association between some risk factors and LBW in Syrian refugee and Turkish population in Kilis, Turkey.

Methods

Study design

This is a cross sectional retrospective epidemiological study has been conducted in a public-hospital at Kilis, Turkey. Kilis State Hospital is the only hospital in the region with a maternity department. Almost all births in Turkey occur in hospitals, in the maternity department. In 2013, 97.2% of mothers gave birth in hospitals, while much smaller proportions gave birth at home (2.3%) or in other settings including births occurring before arrival at hospital (0.5% mothers)[3].

Method/study procedure

The data were collected from birth records obtained between January 01, 2016 and December 31, 2016. The study population was comprised of hospital files of all women who gave birth in the above-mentioned period and their newborns; the total number of cases was 4379. No sample was drawn and all singleton live births in Kilis State Hospital, in the study period, were included except those preterm or infants with congenital anomalies. Data was recorded with the assistance of pre-tested & pre-designed survey. Birth records include the maternal age (years), mother's nationality, gender of infant, mode of birth (vaginal, cesarean), and birth weight (gram). LBW is defined as less than 2,500 grams2. The study protocol was reviewed and approved by the Gaziantep University Clinical Research Ethics Board (Reference Number: 2017/144).

Data analysis

SPSS 16.0 was used for processing and evaluation of the data. Simple descriptive analysis and Chi-Square test were applied to determine the associated factors of low birth weight. Logistic regression analysis was used to assess relationship between LBW and maternal and infant bio-demographic characteristics. Factors with a P-value < 0.05 were deemed to be statistically significant.

Results

The median age of mothers was 25 (range 12–51) with majority of mothers aged 20-34 years. The frequency of Turkish national's mother was 35.8%, while the frequency of Syrian national's mother was 64.2%. The study population comprised 4379 infants, 49.9% (2185) were males. Of the total number of births there was 3326 (76.0%) vaginally completed and 1053 (24.0%) by cesarean section [Table 1].

Table 1

Distribution of mother and baby for some descriptive characteristics

Variable	Categories	n	%
Maternal age (years)	≤19	751	17.2
(Median: 25)	20–34	3098	70.7
	≥35	530	12.1
Mother nationality	Turkish	1569	35.8
	Syrian	2810	64.2
Gender of infant	Male	2185	49.9
	Female	2194	50.1
Mode of birth	Vaginal birth	3326	76.0
	Caesarean birth	1053	24.0
Total		4379	100.0

All the variables displayed in the Table 2 were significantly associated with infant birth weight (p<0.05). The prevalence of LBW was the lowest among mothers aged 20–34 years (8.5% for mothers aged ≤19 years, 6.0% for mothers aged 20–34 years, and 8.1% for mothers aged ≥35 years (p<0.05)). The prevalence of LBW was found to be higher in Syrian refugee mothers (7.7 percent) than in Turkish mothers (4.9 percent) (p<0.05). Birth weight was influenced by the gender of a child; whereas about 5.8 percent of male infants were born with LBW 7.6 percent of female infants had LBW (p<0.05). LBW prevalence was higher in infants born with cesarean birth (8.2 percent) than infants born with vaginal birth (6.2 percent) (p<0.05).

Table 2

Relationship between maternal and infant bio-demographic characteristics and birth weight

Variable	Categories	Low birth weight				Total		X2	*p
		Yes		No
		< 2500 g		≥ 2500 g
		n	%	n	%	n	%
Maternal age(years)	≤19	64	8.5	687	91.5	751	100	8.092	<0.05
	20-34	186	6.0	2912	94	3098	100
	≥35	43	8.1	487	91.9	530	100
Mothernationality	Turkish	77	4.9	1492	95.1	1569	100	12.456	<0.05
	Syrian	216	7.7	2594	92.3	2810	100
Gender ofinfant	Male	126	5.8	2059	94.2	2185	100	5.969	<0.05
	Female	167	7.6	2027	92.4	2194	100
Mode of birth	Vaginal birth	207	6.2	3119	93.8	3326	100	4.838	<0.05
	Caesarean birth	86	8.2	967	91.8	1053	100
Total		293	6.7	4086	93.3	4379	100

Chi-square test

A binary logistic regression shows that mothers who were in the age group of less than 19 years were more likely to deliver LBW infants than those mothers in the age group of 20-34 years (OR: 1.42; 95% CI: 1.05–1.92). Syrian refugee mothers were significantly more likely to be LBW relative to Turkish mothers (OR: 1.67, 95% CI: 1.26–2.19). Female infants were significantly more likely to be LBW relative to male infants (OR: 1.33, 95% CI: 1.05–1.70). Delivery using lower segment caesarian section was found to have more risk in developing LBW compared to infants delivered via vaginal delivery (OR: 1.52, 95% CI: 1.16–2.00) [Table 3].

Table 3

Binary logistic regression analysis of low birth weight risk factors

Variable (n=338)	Categories	B	p	Oddsratio	95% CI
					Lower	Upper
Maternalage(years)	≤19	0.352	0.022	1.423	1.052	1.923
	20-34+	-	-	-	-	-
	≥35	0.061	0.772	1.063	0.704	1.605
Mother nationality	Turkish[+]	-	-	-	-	-
	Syrian	0.513	0.000	1.670	1.269	2.196
Gender of infant	Male[+]	-	-	-	-	-
	Female	0.290	0.018	1.337	1.051	1.700
Mode of birth	Vaginal birth[+]	-	-	-	-	-
	Caesarean birth	0.423	0.002	1.527	1.165	2.000
Constant		1.782	0.000	5.945

Reference group

Discussion

In our study, the percentage of LBW infants was found to be 6.7% in all groups and this value appears to be at the level of developed regions (7.0%)[2]. This finding is inconsistent with that of the national figure which is 10.0%3. This difference might be due to the difference in sample size, study setting, delivery site, and types of health facilities, as this study is carried out only among the neonate delivered in one center located in Kilis Province, while the study at national levels included the neonate delivered in multicentre and multiple region. Another possible reason for lower prevalence of low birth weight in our study area could be due to unreported home deliveries.

In this study, the percentage of LBW in infants born from young mothers was higher than that of mothers who gave birth in middle and advanced age. This result may be clarified by that the younger age ≤ 19 years tended to be unmarried, still in high school, unplanned pregnancy and they too have the problems of biological immaturity concomitant with poor maternal selfcare and insufficient nutrition[11]. Similarly, other studies have also found that infants born from mothers under the age of 19 had a high risk of being LBW[1,10,11,12,13,14,15]. But this result is in contrast to a study done in India, there was no significant relationship between maternal age and LBW[16].

In our study, the percentage of LBW in Syrian refugees was significantly higher than the Turkish. Similarly, in a study conducted in Pakistan, the percentage of LBW was 2.5 times higher in Afghan refugees than in local populations[12]. Likewise, in a study conducted in Hong Kong, the percentage of LBW in Vietnamese refugees was twice as high as Chinese[17]. This can be attributed to the fact that refugee women are exposed to homelessness, malnutrition and limited access to health services during pregnancy.

In a study conducted in Nigeria, it has been reported that female infants are more likely to have LBW than male infants[15]. Similarly, in a study conducted in Northwest Ethiopia, female infants were found to have lower birth weights than male infants[18]. Similar to the findings of other studies in our study, the percentage of LBW in female infants was higher than that of male infants. The birth weight of male infants is generally higher than female infants. This difference starts after 28 weeks of gestation. Although the exact mechanism impacting the difference in birth weight is unknown, it might be due to androgen activities or the Y chromosome that carries genetic material for fetal growth. As a result, male infants could have higher intrauterine growth and birth weight than their female counterparts[19].

In our study, the percentage of LBW in infants born by caesarean section was significantly higher than that of infants born by vaginal delivery. In a study conducted in Malaysia, giving birth using lower segment caesarean section (LSCS) was associated with a higher risk of LBW in infants, compared to vaginal births[5]. But this result is in contrast to a study done in India, a negative relationship was found between cesarean birth and LBW 1. In other studies, conducted in India and Nigeria, there was no significant relationship between cesarean birth and LBW[20,21]. However, this association should be interpreted with caution cases. They may need to undergone emergency LSCS due to threatened maternal condition but still in premature gestation such as severe pre-eclampsia, eclampsia and bleeding placenta praevia[5].

There are some limitations to this study. Firstly, there are too few factors such as other socio demographic characteristic such as paternal weight, maternal education level, smoking status of parents, drug ingestion and occupation that may have impact for LBW newborn children cannot be included in this study due to lacking of information. Secondly, births outside the hospital were not included in the study, and therefore it was not possible to generalize the results to a particular population as compared to population based studies.

In conclusion, significant association was found between young maternal age, Syrian refugee mother, female infants, cesarean delivery and LBW. Improving a mother's information of and practice for a healthy pregnancy ought to be emphasized to invert these LBW trends. Our data highlights an imperative need to devise interventions to reduce adverse birth outcomes for pregnancies of teenagers. Health specialists ought to encourage young mothers to go to focused antenatal care as recommended by Ministry of Health of Turkey. A specialized maternal office centre that's friendly for adolescent/teenage mothers is advisable so as to improve on completion rates and handle high hazard pregnancies. Further detailed study on Syrian refugee outcomes is recommended to understand the main causes of LBW compared to Turkish mothers. An awareness of the likely health issues in this group of women will enable health care administrations to address the refugees' particular health needs and ensure maternal and fetal well-being. Identification of high-risk mothers and early detection and administration of the risk factors would decrease frequency of low birth weight and related short-term and long-term consequences.