Literature DB >> 33157082

Association of DLL1 with type 1 diabetes in patients characterized by low polygenic risk score.

Jingchun Qu1, Hui-Qi Qu1, Jonathan P Bradfield2, Joseph T Glessner1, Xiao Chang1, Lifeng Tian1, Michael E March1, Jeffrey D Roizen3, Patrick M Sleiman4, Hakon Hakonarson5.   

Abstract

Type 1 diabetes (T1D) is a heterogeneous disease. This study identified T1D cases with low polygenic risk score (PRS) to better represent T1D cases with less prominent autoimmune response (T1bD), and performed a gene-based association study to identify novel susceptibility loci in two independent cohorts, characterized by low PRS. The Notch ligand Delta-like 1 gene (DLL1) was identified with genome-wide significance in both cohorts, highlighting the roles of DLL1 genetic variants in T1D patients with low PRS, supported by functional evidence from a recent study by Rubey et al.
Copyright © 2020 Elsevier Inc. All rights reserved.

Entities:  

Keywords:  DLL1; Gene-based test; Genome-wide Association Study; Polygenic risk score; Type 1 diabetes

Year:  2020        PMID： 33157082     DOI： 10.1016/j.metabol.2020.154418

Source DB:  PubMed          Journal:  Metabolism        ISSN： 0026-0495            Impact factor:   8.694


  5 in total

1.  Functional Studies of Genetic Variants Associated with Human Diseases in Notch Signaling-Related Genes Using Drosophila.

Authors:  Sheng-An Yang; Jose L Salazar; David Li-Kroeger; Shinya Yamamoto
Journal:  Methods Mol Biol       Date:  2022

2.  Combined application of genetic and polygenic risk scores for type 1 diabetes risk prediction.

Authors:  Hui-Qi Qu; Jingchun Qu; Jonathan Bradfield; Joseph Glessner; Xiao Chang; Michael March; Frank D Mentch; Jeffrey D Roizen; John J Connolly; Patrick Sleiman; Hakon Hakonarson
Journal:  Diabetes Obes Metab       Date:  2021-06-03       Impact factor: 6.577

Review 3.  Polygenic autoimmune disease risk alleles impacting B cell tolerance act in concert across shared molecular networks in mouse and in humans.

Authors:  Isaac T W Harley; Kristen Allison; R Hal Scofield
Journal:  Front Immunol       Date:  2022-08-24       Impact factor: 8.786

4.  Insights into non-autoimmune type 1 diabetes with 13 novel loci in low polygenic risk score patients.

Authors:  Jingchun Qu; Hui-Qi Qu; Jonathan P Bradfield; Joseph T Glessner; Xiao Chang; Lifeng Tian; Michael March; John J Connolly; Jeffrey D Roizen; Patrick M A Sleiman; Hakon Hakonarson
Journal:  Sci Rep       Date:  2021-08-06       Impact factor: 4.379

5.  Genetic architecture of type 1 diabetes with low genetic risk score informed by 41 unreported loci.

Authors:  Hui-Qi Qu; Jingchun Qu; Jonathan Bradfield; Luc Marchand; Joseph Glessner; Xiao Chang; Michael March; Jin Li; John J Connolly; Jeffrey D Roizen; Patrick Sleiman; Constantin Polychronakos; Hakon Hakonarson
Journal:  Commun Biol       Date:  2021-07-23
  5 in total

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