Literature DB >> 33157047

CRISPR-Cas Tools and Their Application in Genetic Engineering of Human Stem Cells and Organoids.

Delilah Hendriks1, Hans Clevers2, Benedetta Artegiani3.   

Abstract

CRISPR-Cas technology has revolutionized biological research and holds great therapeutic potential. Here, we review CRISPR-Cas systems and their latest developments with an emphasis on application to human cells. We also discuss how different CRISPR-based strategies can be used to accomplish a particular genome engineering goal. We then review how different CRISPR tools have been used in genome engineering of human stem cells in vitro, covering both the pluripotent (iPSC/ESC) and somatic adult stem cell fields and, in particular, 3D organoid cultures. Finally, we discuss the progress and challenges associated with CRISPR-based genome editing of human stem cells for therapeutic use.
Copyright © 2020 Elsevier Inc. All rights reserved.

Entities:  

Year:  2020        PMID： 33157047     DOI： 10.1016/j.stem.2020.10.014

Source DB:  PubMed          Journal:  Cell Stem Cell        ISSN： 1875-9777            Impact factor:   24.633


  24 in total

Review 1.  CRISPR in cancer biology and therapy.

Authors:  Alyna Katti; Bianca J Diaz; Christina M Caragine; Neville E Sanjana; Lukas E Dow
Journal:  Nat Rev Cancer       Date:  2022-02-22       Impact factor: 60.716

Review 2.  Promises and Challenges of Organoid-Guided Precision Medicine.

Authors:  Shree Bose; Hans Clevers; Xiling Shen
Journal:  Med (N Y)       Date:  2021-09-10

3.  Broadening prime editing toolkits using RNA-Pol-II-driven engineered pegRNA.

Authors:  Shisheng Huang; Zhenwu Zhang; Wanyu Tao; Yao Liu; Xiangyang Li; Xiaolong Wang; Javad Harati; Peng-Yuan Wang; Xingxu Huang; Chao-Po Lin
Journal:  Mol Ther       Date:  2022-07-06       Impact factor: 12.910

4.  Ethical Challenges in Organoid Use.

Authors:  Vasiliki Mollaki
Journal:  BioTech (Basel)       Date:  2021-06-28

Review 5.  Modeling congenital heart disease: lessons from mice, hPSC-based models, and organoids.

Authors:  Kavitha S Rao; Vasumathi Kameswaran; Benoit G Bruneau
Journal:  Genes Dev       Date:  2022-06-01       Impact factor: 12.890

Review 6.  Human Stem Cell and Organoid Models to Advance Acute Kidney Injury Diagnostics and Therapeutics.

Authors:  Naomi Pode-Shakked; Prasad Devarajan
Journal:  Int J Mol Sci       Date:  2022-06-29       Impact factor: 6.208

Review 7.  Cancer Risk and Mutational Patterns Following Organ Transplantation.

Authors:  Yangyang Shen; Di Lian; Kai Shi; Yuefeng Gao; Xiaoxiang Hu; Kun Yu; Qian Zhao; Chungang Feng
Journal:  Front Cell Dev Biol       Date:  2022-06-28

8.  Establishment of human fetal hepatocyte organoids and CRISPR-Cas9-based gene knockin and knockout in organoid cultures from human liver.

Authors:  Delilah Hendriks; Benedetta Artegiani; Huili Hu; Susana Chuva de Sousa Lopes; Hans Clevers
Journal:  Nat Protoc       Date:  2020-11-27       Impact factor: 13.491

9.  Efficient generation of isogenic primary human myeloid cells using CRISPR-Cas9 ribonucleoproteins.

Authors:  Joseph Hiatt; Devin A Cavero; Michael J McGregor; Weihao Zheng; Jonathan M Budzik; Theodore L Roth; Kelsey M Haas; David Wu; Ujjwal Rathore; Anke Meyer-Franke; Mohamed S Bouzidi; Eric Shifrut; Youjin Lee; Vigneshwari Easwar Kumar; Eric V Dang; David E Gordon; Jason A Wojcechowskyj; Judd F Hultquist; Krystal A Fontaine; Satish K Pillai; Jeffery S Cox; Joel D Ernst; Nevan J Krogan; Alexander Marson
Journal:  Cell Rep       Date:  2021-05-11       Impact factor: 9.423

Review 10.  Integration of Transformative Platforms for the Discovery of Causative Genes in Cardiovascular Diseases.

Authors:  Haocheng Lu; Jifeng Zhang; Y Eugene Chen; Minerva T Garcia-Barrio
Journal:  Cardiovasc Drugs Ther       Date:  2021-04-15       Impact factor: 3.947
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