OBJECTIVE: Victims of child sexual abuse (CSA) present with a higher risk of psychotic disorders. However, the developmental course of psychosis following CSA, such as the age at onset, remains unknown. This study aimed to determine whether the age at onset of psychotic disorders was influenced by sexual abuse, sex, and confounding factors (substance misuse, intellectual disability, and socioeconomic status). METHOD: A prospective matched-cohort design was used, with administrative databases from a child protection agency (CPA) and a public health system. Children who received a substantiated report of CSA at the CPA and whose health data could be retrieved were selected (n = 882) and matched with children from the general population using their date of birth, sex, and geographical area. Survival analysis was performed to estimate the association between sexual abuse, sex, and confounding factors and the age at onset of psychotic disorders. RESULTS: Sexual abuse and substance misuse are significantly associated with the age at onset of psychotic disorders. In the sexually abused group, only substance misuse is associated with the age at onset of psychotic disorders, but this was not significant for the general population. CONCLUSIONS: These findings highlight the importance of prevention of psychotic disorders among sexually abused youth, especially those with a substance misuse diagnosis.
OBJECTIVE: Victims of childsexual abuse (CSA) present with a higher risk of psychotic disorders. However, the developmental course of psychosis following CSA, such as the age at onset, remains unknown. This study aimed to determine whether the age at onset of psychotic disorders was influenced by sexual abuse, sex, and confounding factors (substance misuse, intellectual disability, and socioeconomic status). METHOD: A prospective matched-cohort design was used, with administrative databases from a child protection agency (CPA) and a public health system. Children who received a substantiated report of CSA at the CPA and whose health data could be retrieved were selected (n = 882) and matched with children from the general population using their date of birth, sex, and geographical area. Survival analysis was performed to estimate the association between sexual abuse, sex, and confounding factors and the age at onset of psychotic disorders. RESULTS:Sexual abuse and substance misuse are significantly associated with the age at onset of psychotic disorders. In the sexually abused group, only substance misuse is associated with the age at onset of psychotic disorders, but this was not significant for the general population. CONCLUSIONS: These findings highlight the importance of prevention of psychotic disorders among sexually abused youth, especially those with a substance misuse diagnosis.
Authors: Wenche Ten Velden Hegelstad; Tor K Larsen; Bjørn Auestad; Julie Evensen; Ulrik Haahr; Inge Joa; Jan O Johannesen; Johannes Langeveld; Ingrid Melle; Stein Opjordsmoen; Jan Ivar Rossberg; Bjørn Rishovd Rund; Erik Simonsen; Kjetil Sundet; Per Vaglum; Svein Friis; Thomas McGlashan Journal: Am J Psychiatry Date: 2012-04 Impact factor: 18.112
Authors: Esben Agerbo; Patrick F Sullivan; Bjarni J Vilhjálmsson; Carsten B Pedersen; Ole Mors; Anders D Børglum; David M Hougaard; Mads V Hollegaard; Sandra Meier; Manuel Mattheisen; Stephan Ripke; Naomi R Wray; Preben B Mortensen Journal: JAMA Psychiatry Date: 2015-07 Impact factor: 21.596
Authors: Justin Davis; Harris Eyre; Felice N Jacka; Seetal Dodd; Olivia Dean; Sarah McEwen; Monojit Debnath; John McGrath; Michael Maes; Paul Amminger; Patrick D McGorry; Christos Pantelis; Michael Berk Journal: Neurosci Biobehav Rev Date: 2016-04-09 Impact factor: 8.989
Authors: Filippo Varese; Feikje Smeets; Marjan Drukker; Ritsaert Lieverse; Tineke Lataster; Wolfgang Viechtbauer; John Read; Jim van Os; Richard P Bentall Journal: Schizophr Bull Date: 2012-03-29 Impact factor: 9.306