Maria Peris-Celda1, Christopher S Graffeo2, Avital Perry3, Geffen Kleinstern4, Panagiotis Kerezoudis3, Colin L W Driscoll5, Matthew L Carlson6, Michael J Link7. 1. Department of Neurosurgery, Albany Medical Center, Albany, NY; Department of Neurologic Surgery, Mayo Clinic, Rochester, MN. 2. Department of Neurosurgery, Albany Medical Center, Albany, NY. 3. Department of Neurologic Surgery, Mayo Clinic, Rochester, MN. 4. Department Health Sciences Research, Mayo Clinic, Rochester, MN. 5. Department Otolaryngology-Head and Neck Surgery, Mayo Clinic, Rochester, MN. 6. Department of Neurologic Surgery, Mayo Clinic, Rochester, MN; Department Otolaryngology-Head and Neck Surgery, Mayo Clinic, Rochester, MN. 7. Department of Neurologic Surgery, Mayo Clinic, Rochester, MN; Department Otolaryngology-Head and Neck Surgery, Mayo Clinic, Rochester, MN. Electronic address: link.michael@mayo.edu.
Abstract
OBJECTIVE: To assess the impact of differential hearing loss on QOL in sporadic unilateral vestibular schwannoma. PATIENTS AND METHODS: Cross-sectional observational multicenter study including 422 patients with vestibular schwannoma and formal audiometry within 1 year of survey administration, analyzed using multivariable regression. RESULTS: Among 422 patients included, the median age was 57 (range, 18-81) years; 223 (53%) were women. Among 390 patients with complete audiometric data, American Academy of Otolaryngology-Head and Neck Surgery class was A in 134 (34%), B in 69 (18%), C in 26 (7%), and D in 161 (41%). A total of 335 of 390 (86%) reported subjective ipsilateral hearing loss (median severity, 6/10 [1 = normal, 10 = deaf]), 166 (43%) reported ipsilateral inability to use the telephone, 155 (37%) reported that hearing loss had affected personal relationships, and 213 (51%) reported difficulty with conversations. After adjusting for age and sex, the odds ratio (OR) for hearing loss adversely affecting relationships was 4.4 for class B hearing vs class A (95% CI, 2.1-9.4; P<.0001). The OR for difficulty with conversations was 2.7 for class B vs class A (95% CI, 1.4-5.3; P=.003). The OR for lost ipsilateral telephone use was 6.3 for class B vs class A (95% CI, 3.2-13.0; P<.0001). Differences between class B and class C were not significant. WRS outperformed PTA as a predictor of hearing-related QOL. The optimal threshold for predicting a significant adverse impact on QOL was WRS less than 72% to 76%. CONCLUSION: Hearing loss adversely affects QOL after only modest audiometric disability. The WRS alone appears to be a much more reliable predictor of hearing-related QOL than PTA or American Academy of Otolaryngology-Head and Neck Surgery class.
OBJECTIVE: To assess the impact of differential hearing loss on QOL in sporadic unilateral vestibular schwannoma. PATIENTS AND METHODS: Cross-sectional observational multicenter study including 422 patients with vestibular schwannoma and formal audiometry within 1 year of survey administration, analyzed using multivariable regression. RESULTS: Among 422 patients included, the median age was 57 (range, 18-81) years; 223 (53%) were women. Among 390 patients with complete audiometric data, American Academy of Otolaryngology-Head and Neck Surgery class was A in 134 (34%), B in 69 (18%), C in 26 (7%), and D in 161 (41%). A total of 335 of 390 (86%) reported subjective ipsilateral hearing loss (median severity, 6/10 [1 = normal, 10 = deaf]), 166 (43%) reported ipsilateral inability to use the telephone, 155 (37%) reported that hearing loss had affected personal relationships, and 213 (51%) reported difficulty with conversations. After adjusting for age and sex, the odds ratio (OR) for hearing loss adversely affecting relationships was 4.4 for class B hearing vs class A (95% CI, 2.1-9.4; P<.0001). The OR for difficulty with conversations was 2.7 for class B vs class A (95% CI, 1.4-5.3; P=.003). The OR for lost ipsilateral telephone use was 6.3 for class B vs class A (95% CI, 3.2-13.0; P<.0001). Differences between class B and class C were not significant. WRS outperformed PTA as a predictor of hearing-related QOL. The optimal threshold for predicting a significant adverse impact on QOL was WRS less than 72% to 76%. CONCLUSION:Hearing loss adversely affects QOL after only modest audiometric disability. The WRS alone appears to be a much more reliable predictor of hearing-related QOL than PTA or American Academy of Otolaryngology-Head and Neck Surgery class.
Authors: Eric Nisenbaum; Carly Misztal; Mikhaylo Szczupak; Torin Thielhelm; Stefanie Peña; Christine Mei; Stefania Goncalves; Olena Bracho; Ruixuan Ma; Michael E Ivan; Jacques Morcos; Fred Telischi; Xue-Zhong Liu; Cristina Fernandez-Valle; Christine T Dinh Journal: OTO Open Date: 2021-11-23