Deepti Bettampadi1,2, Brittney Dickey1,2, Martha Abrahamsen1, Bradley Sirak1, Maria Luiza Baggio3, Lenice Galan4, Roberto Carvalho Silva4, Luisa Villa3,5, Eduardo Lazcano Ponce6, Anna R Giuliano1,2. 1. Center for Immunization and Infection Research in Cancer, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida, USA. 2. Department of Cancer Epidemiology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida, USA. 3. Instituto do Cancer do Estado de São Paulo, São Paulo, Brazil. 4. Centro de Referencia e Treinamento em DST/AIDS, São Paulo, Brazil. 5. Department of Radiology and Oncology, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil. 6. Center for Population Health Research, National Institute of Public Health, Cuernavaca, Morelos, Mexico.
Abstract
BACKGROUND: Human papillomavirus (HPV) causes oral warts and oropharyngeal cancer (OPC). Human papillomavirus-attributable OPC incidence among men is significantly increasing worldwide, yet few studies have reported oral HPV across multiple countries or examined factors associated with low- and high-risk HPV separately. METHODS: Oral gargles from 3095 men in the multinational HPV Infection in Men (HIM) Study were HPV genotyped. Multivariable models assessed factors independently associated with high-risk and low-risk HPV prevalence. RESULTS: The prevalence of high-risk and low-risk HPV was 6.0% and 2.8%, respectively. Greater number of sexual partners was only associated with high-risk HPV (1.88; 95% confidence interval [CI], 1.22-2.90) prevalence. In multivariable models, residing in Mexico (1.66; 95% CI, 1.15-2.40) and smoking (1.66; 95% CI, 1.13-2.44) were significantly associated with high-risk HPV, and history of consistent gum bleeding (2.16; 95% CI, 1.35-3.45) was significantly associated with low-risk HPV. Gender of the sexual partner did not alter the results for either high- or low-risk HPV endpoints. CONCLUSIONS: Different factors were independently associated with high- and low-risk oral HPV. Oral sexual behaviors were associated with high-risk HPV, and oral health was associated with low-risk HPV. High-risk HPV prevalence differed by country of residence, highlighting the need for additional studies in multiple countries.
BACKGROUND: Human papillomavirus (HPV) causes oral warts and oropharyngeal cancer (OPC). Human papillomavirus-attributable OPC incidence among men is significantly increasing worldwide, yet few studies have reported oral HPV across multiple countries or examined factors associated with low- and high-risk HPV separately. METHODS: Oral gargles from 3095 men in the multinational HPV Infection in Men (HIM) Study were HPV genotyped. Multivariable models assessed factors independently associated with high-risk and low-risk HPV prevalence. RESULTS: The prevalence of high-risk and low-risk HPV was 6.0% and 2.8%, respectively. Greater number of sexual partners was only associated with high-risk HPV (1.88; 95% confidence interval [CI], 1.22-2.90) prevalence. In multivariable models, residing in Mexico (1.66; 95% CI, 1.15-2.40) and smoking (1.66; 95% CI, 1.13-2.44) were significantly associated with high-risk HPV, and history of consistent gum bleeding (2.16; 95% CI, 1.35-3.45) was significantly associated with low-risk HPV. Gender of the sexual partner did not alter the results for either high- or low-risk HPV endpoints. CONCLUSIONS: Different factors were independently associated with high- and low-risk oral HPV. Oral sexual behaviors were associated with high-risk HPV, and oral health was associated with low-risk HPV. High-risk HPV prevalence differed by country of residence, highlighting the need for additional studies in multiple countries.
Authors: Paul K S Chan; Alexander R Chang; Jo L K Cheung; Denise P C Chan; L Y Xu; Nelson L S Tang; Augustine F Cheng Journal: J Infect Dis Date: 2001-12-05 Impact factor: 5.226
Authors: B Kleter; L J van Doorn; L Schrauwen; A Molijn; S Sastrowijoto; J ter Schegget; J Lindeman; B ter Harmsel; M Burger; W Quint Journal: J Clin Microbiol Date: 1999-08 Impact factor: 5.948
Authors: Deepti Bettampadi; Luisa L Villa; Eduardo L Ponce; Jorge Salmeron; Bradley A Sirak; Martha Abrahamsen; Julie A Rathwell; Richard R Reich; Anna R Giuliano Journal: Int J Cancer Date: 2019-11-01 Impact factor: 7.396
Authors: Anil K Chaturvedi; William F Anderson; Joannie Lortet-Tieulent; Maria Paula Curado; Jacques Ferlay; Silvia Franceschi; Philip S Rosenberg; Freddie Bray; Maura L Gillison Journal: J Clin Oncol Date: 2013-11-18 Impact factor: 44.544
Authors: Anna R Giuliano; Raphael Viscidi; B Nelson Torres; Donna J Ingles; Staci L Sudenga; Luisa L Villa; Maria Luiza Baggio; Martha Abrahamsen; Manuel Quiterio; Jorge Salmeron; Eduardo Lazcano-Ponce Journal: Papillomavirus Res Date: 2015-12-01