| Literature DB >> 3315118 |
K M Hargreaves1, G P Mueller, R Dubner, D Goldstein, R A Dionne.
Abstract
The analgesic activity of corticotropin releasing factor (CRF) was determined in a clinical model and in the rat hot plate test. Patients administered CRF reported significantly less postoperative pain than patients pretreated with placebo. In rats, injection of CRF resulted in a significant analgesia which was comparable in both intensity and duration to a 300 times greater molar dose of morphine. These findings suggest that endogenous CRF may play a physiologic role in modulating pain when released under conditions of stress.Entities:
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Year: 1987 PMID： 3315118 DOI： 10.1016/0006-8993(87)90550-6
Source DB: PubMed Journal: Brain Res ISSN： 0006-8993 Impact factor: 3.252