Shuaishuai Chen1, Juping Du1, Weibo Zhao2, Rong Cao1, Na Wang1, Jun Li1, Bo Shen1, Shiyong Chen1. 1. Department of Clinical Laboratory, Taizhou Hospital of Zhejiang Province affiliated to Wenzhou Medical University, Linhai 317000, Zhejiang Province, China. 2. Department of Orthopaedic Surgery, Taizhou Hospital of Zhejiang Province affiliated to Wenzhou Medical University, Linhai 317000, Zhejiang Province, China.
Abstract
Aim: Data from 124 rheumatoid arthritis (RA) patients and 69 healthy controls were collected. Materials & methods: ELISA was performed to detect serum FABP4 levels. Results: FABP4 level was elevated in RA patients and positively associated with 28-joint disease activity score, high-sensitivity C-reactive protein, erythrocyte sedimentation rate, total cholesterol, triglyceride and low-density lipoprotein cholesterol. Additionally, the area under the receiver operating characteristic curve for FABP4 was 0.685 for RA patients versus healthy controls (p = 0.001). RA patients were separated into low, moderate and high disease activity based on 28-joint disease activity score. The area under the receiver operating characteristic value was 0.877 for RA patients with high disease activity versus healthy controls (p < 0.001). Conclusion: FABP4 was associated with disease activity in RA patients.
Aim: Data from 124 rheumatoid arthritis (RA) patients and 69 healthy controls were collected. Materials & methods: ELISA was performed to detect serum FABP4 levels. Results:FABP4 level was elevated in RApatients and positively associated with 28-joint disease activity score, high-sensitivity C-reactive protein, erythrocyte sedimentation rate, total cholesterol, triglyceride and low-density lipoprotein cholesterol. Additionally, the area under the receiver operating characteristic curve for FABP4 was 0.685 for RApatients versus healthy controls (p = 0.001). RApatients were separated into low, moderate and high disease activity based on 28-joint disease activity score. The area under the receiver operating characteristic value was 0.877 for RApatients with high disease activity versus healthy controls (p < 0.001). Conclusion:FABP4 was associated with disease activity in RApatients.
Authors: Ivan Arias de la Rosa; Maria Dolores López-Montilla; Cristobal Román-Rodríguez; Carlos Pérez-Sánchez; Ignacio Gómez-García; Clementina López-Medina; Maria Lourdes Ladehesa-Pineda; Maria Del Carmen Ábalos-Aguilera; Desiree Ruiz; Alejandra Maria Patiño-Trives; Maria Luque-Tévar; Isabel Añón-Oñate; Maria Jose Pérez-Galán; Rocio Guzmán-Ruiz; Maria M Malagón; Chary López-Pedrera; Alejandro Escudero-Contreras; Eduardo Collantes-Estévez; Nuria Barbarroja Journal: J Intern Med Date: 2022-03-02 Impact factor: 13.068