Nicolás Martínez-Velilla1,2, Pedro L Valenzuela3, Mikel L Sáez de Asteasu1,2, Fabricio Zambom-Ferraresi1,2, Robinson Ramírez-Vélez1,2, Antonio García-Hermoso1,2,4, Julian Librero-López1, Javier Gorricho5, Federico Esparza Pérez5, Alejandro Lucia2,6, Mikel Izquierdo1,2. 1. Navarrabiomed, Complejo Hospitalario de Navarra-Universidad Pública de Navarra, Institute for Health Research of Navarre (IdiSNA), Pamplona, Spain. 2. Networking Biomedical Research Center (CIBER) of Frailty and Healthy Aging, Instituto de Salud Carlos III, Madrid, Spain. 3. Department of Systems Biology, University of Alcalá, Madrid, Spain. 4. Laboratorio de Ciencias de la Actividad Física, el Deporte y la Salud, Facultad de Ciencias Médicas, Universidad de Santiago de Chile, USACH, Santiago, Chile. 5. Department of Health, Government of Navarra, Pamplona, Spain. 6. Faculty of Sport Sciences, Universidad Europea de Madrid and Research Institute Hospital 12 de Octubre, Madrid, Spain.
Abstract
OBJECTIVE: To analyze the effects of a tailored exercise intervention in acutely hospitalized elderly diabetic patients. RESEARCH DESIGN AND METHODS: This is an ancillary analysis of a randomized controlled trial (RCT). A total of 103 acutely hospitalized elderly adults (mean age ~87 years) with type II diabetes were randomized to an intervention (exercise, n = 54) or control group (usual care, n = 49). The primary endpoint was change in functional status from baseline to hospital discharge as assessed with the Barthel Index and the Short Physical Performance Battery (SPPB). Secondary endpoints comprised cognitive function and mood status, quality of life (QoL), incidence of delirium, and handgrip strength. Exercise-related side effects, length of hospital stay, and incidence of falls during hospitalization were also assessed, as well as transfer to nursing homes, hospital readmission, and mortality during a 3-month follow-up. RESULTS: The median length of stay was 8 days (interquartile range, 4) for both groups. The intervention was safe and provided significant benefits over usual care on SPPB (2.7 [95% confidence interval (CI) 1.8, 3.5]) and Barthel Index (8.5 [95% CI: 3.9, 13.1]), as well as on other secondary endpoints such as cognitive status, depression, QoL, and handgrip strength (all P < 0.05). No significant between-group differences were found for the remainder of secondary endpoints. CONCLUSIONS: An in-hospital individualized multicomponent exercise intervention was safe and effective for the prevention of functional and cognitive decline in acutely hospitalized elderly diabetic patients, although it had no influence on other endpoints assessed during hospitalization or at the 3-month follow-up after discharge.
RCT Entities:
OBJECTIVE: To analyze the effects of a tailored exercise intervention in acutely hospitalized elderly diabeticpatients. RESEARCH DESIGN AND METHODS: This is an ancillary analysis of a randomized controlled trial (RCT). A total of 103 acutely hospitalized elderly adults (mean age ~87 years) with type II diabetes were randomized to an intervention (exercise, n = 54) or control group (usual care, n = 49). The primary endpoint was change in functional status from baseline to hospital discharge as assessed with the Barthel Index and the Short Physical Performance Battery (SPPB). Secondary endpoints comprised cognitive function and mood status, quality of life (QoL), incidence of delirium, and handgrip strength. Exercise-related side effects, length of hospital stay, and incidence of falls during hospitalization were also assessed, as well as transfer to nursing homes, hospital readmission, and mortality during a 3-month follow-up. RESULTS: The median length of stay was 8 days (interquartile range, 4) for both groups. The intervention was safe and provided significant benefits over usual care on SPPB (2.7 [95% confidence interval (CI) 1.8, 3.5]) and Barthel Index (8.5 [95% CI: 3.9, 13.1]), as well as on other secondary endpoints such as cognitive status, depression, QoL, and handgrip strength (all P < 0.05). No significant between-group differences were found for the remainder of secondary endpoints. CONCLUSIONS: An in-hospital individualized multicomponent exercise intervention was safe and effective for the prevention of functional and cognitive decline in acutely hospitalized elderly diabeticpatients, although it had no influence on other endpoints assessed during hospitalization or at the 3-month follow-up after discharge.
Authors: Stig Molsted; Lasse Kusk; Søren Mingon Esbensen; Thomas Martin Mohr; Malene Bang Vind; Camilla Hess; Thomas Bandholm; Morten Tange Kristensen; Cornelie Mølsted Flege; Peter Lommer Kristensen Journal: Int J Environ Res Public Health Date: 2022-01-18 Impact factor: 3.390
Authors: Sergi Blancafort Alias; César Cuevas-Lara; Nicolás Martínez-Velilla; Fabricio Zambom-Ferraresi; Maria Eugenia Soto; Neda Tavassoli; Céline Mathieu; Eva Heras Muxella; Pablo Garibaldi; Maria Anglada; Jordi Amblàs; Sebastià Santaeugènia; Joan Carles Contel; Àlex Domingo; Antoni Salvà Casanovas Journal: Int J Environ Res Public Health Date: 2021-06-02 Impact factor: 3.390