Individual Perceived Stress Mediates Psychological Distress in Medical Workers During COVID-19 Epidemic Outbreak in Wuhan.

BACKGROUND: Since the novel coronavirus disease (COVID-19) outbreak in Wuhan, thousands of medical workers have been dispatched to support Wuhan against the virus. The purpose of this study was to identify the independent risk factors for psychological distress in order to develop a more effective strategy and precise evidence-based psychological intervention for medical workers.
METHODS: This multisite cross-sectional survey recruited doctors and nurses from local and nonlocal medical teams working at 16 hospitals in Wuhan to complete this online survey from February to March, 2020. Psychological status was evaluated through Perceived Stress Scales (PSS), Patient Health Questionnaire-9 (PHQ-9), General Anxiety Disorder Scale (GAD-7) and Acute Stress Disorder Scale (ASDS).
RESULTS: Of 966 participants, the prevalence of stress (95.9%), depression (46.0%) and anxiety (39.3%) were high. Local medical workers exhibited even higher scores of PSS, PHQ-9, GAD-7 and ASDS than those from outside Hubei (P<0.001). Females had more severe perceived stress, depression and anxiety than males (P<0.001). Multiple logistic regression showed that perceived stress is associated with increased odds of depression (OR=1.413; 95% CI: 1.338-1.493; P<0.001) and anxiety (OR=1.515; 95% CI: 1.407-1.631; P<0.001).
CONCLUSION: Our findings demonstrated a high prevalence of stress, depression, anxiety and acute distress among medical workers on the front-line during the COVID-19 outbreak in Wuhan. The level of psychological impact may be mediated by individual perceptions of stressful events.

Introduction

Since late December 2019, the novel coronavirus disease (COVID-19) has emerged and rapidly spread in Wuhan, China. COVID-19 can be transmitted person-to-person, and infected patients may develop fatal conditions. Although a number of strict measures such as quarantine and lock down were adopted to curb the spread of COVID-19, a surge of daily new confirmed cases have overwhelmed the health care system in Wuhan. This also led to severe mental health burden in the early phase.1 In order to alleviate the pressure on the medical system in Wuhan, the Chinese government dispatched medical teams from all over the country to support Wuhan. From the end of January 2020, tens of thousand doctors and nurses among other staff from other provinces in China aggregated in Wuhan to fight against COVID-19. By the end of March 2020, these supporting medical workers took over a large portion of responsibilities to diagnose, treat and care for patients with COVID-19, which greatly alleviated the burden on the local health care system in Wuhan and saved thousands of lives and families. However, the challenges these medical workers have been facing were unprecedented, with or without preparation before they landed, as they worked in the closed environment and dealt with highly traumatized infectious patients face to face.

The experience of SARS in 2003 manifested the short- and long-term psychological impact of epidemics on front-line medical workers.2–4 Such psychological distress may be associated with trauma events.5–7 The SARS outbreak has highlighted the importance of psychological intervention on front-line medical workers.8 Therefore, during the COVID-19 epidemic outbreak, the Chinese government has established psychological intervention teams for medical workers in Wuhan to offer peer psychological assistance services, such as psychological counseling, brochures and psychotherapy.9 It is believed that timely and effective psychological intervention would help medical workers take precautions against emotional and psychiatric problems.

It is known that designated and Fangcang shelter hospitals play important role in this massive rescue operation against COVID-19.10,11 Medical workers in both hospitals probably face different risk factors and cope with different psychological distress. Although there are surveys showing the mental distress of medical workers in Wuhan,12–14 it is not known if there is a differencein psychological status between different working locations (designated and shelter hospitals) or different origins of medical teams (Hubei and outside Hubei). This knowledge would facilitate the strategy of developing more effective and precise evidence-based psychological intervention for medical workers. The purpose of this study was to investigate the psychological status in medical workers who work in different locations and from different medical teams in Wuhan in order to identify the independent risk factors.

Methods

Subjects

All procedures were reviewed and approved by Institutional Review Boards of Shanghai Mental Health Center (IRB number: 2020–10). This study was performed in accordance with the guidelines laid out in the Declaration of Helsinki as revised in 1989. This multisite cross-sectional survey recruited doctors and nurses from local and nonlocal medical teams working in 16 hospitals in Wuhan to complete this online survey from February, 2020 to March, 2020. The period of this survey covered the peak of COVID-19 epidemic outbreak in Wuhan. We collected the data via Wenjianxing platform () with an anonymous self-rated questionnaire. All participants were required to meet the following conditions: (1) age >20 years, (2) no dyslexia, (3) front-line medical workers in Wuhan, (4) in good physical health with no heart, liver, kidney or other physical diseases, not take any medicine for nearly 1 month, (5) never been diagnosed with a mental disorder, (6) willing to participate in this survey. The exclusion criterion was that the answer time for all questions was > 30 min or < 2 min. All subjects provided electronicinformed consent before any study-related procedures were performed. Only subjects who selected yes were taken to the questionnaire page and participated in this study.

Clinical Evaluation

The 14-item Perceived Stress Scales (PSS)15 was used to assess life stress with subjects responding how often they had epidemic thoughts and feelings over the last month (0 equating to “never”, 1 equating to “rarely”, 2 equating to “sometimes”, 3 equating to “fairly often”, 4 equating to “very often”). The total PSS score summarizes the total scores of each item, with higher values indicating more life stress. The total PSS score is interpreted as: normal (0–3), mild (4–10), moderate or severe (≥11) perceived stress.

The Patient Health Questionnaire-9 (PHQ-9)16 was used to evaluate the occurrence and severity of depressive symptoms, which exhibits good validity and reliability for screening depression. Subjects rate the frequency of depressive symptoms with the last two weeks on a 4-point scale ranging from 0 equating to “not at all” to 3 equating to “nearly every day”. The severity of depressive symptoms was evaluated as a continuously summarized score (from 0 to 27). The total PHQ-9 score is interpreted as: normal (0–4), mild (5–9), moderate or severe (≥10) depression.

The 7-item General Anxiety Disorder scale (GAD-7)17 was used to measure anxiety severity in the past two weeks. A 4-point Likert scale ranging from 0 equating to “not at all” to 3 equating to “almost every day” in the past two weeks was required for question answering. The total score ranges from 0 to 21 with higher values indicating more severe anxiety. The total GAD-7 score is interpreted as: normal (0–4), mild (5–9), moderate or severe (≥10) anxiety.

The 19-item Acute Stress Disorder Scale (ASDS)18 was used to evaluate the prevalence of psychiatric symptoms of acute distress induced by COVID-19. The ASDS composed of 4 subscales referring to ASD symptoms of dissociation, re-experiencing, avoidance and arousal. Each item is scored on a 5-point Likert scale from 0 equating to “not at all” to 4 equating to “extremely”. The ASDS total score ranges from 0 to 76 with higher values indicating stronger stress. The total ASDS score is interpreted as: normal (0–55), acute stress disorder (≥56).

Statistical Analysis

The data was analyzed using SPSS statistical software version 22.0 (IBM Corp). All tests were two-tailed, and the significance level was set at α=0.05. As the scores of the 4 measurement tools were not normally distributed, so they were presented as median with interquartile ranges (IQRs). Numbers and percentages were used to present the severity of symptoms, which were derived from scores of the scales about stress, depression, anxiety and acute stress disorder. The severity of symptoms between 2 or more groups were compared using the nonparametric Mann–Whitney U-test and Kruskal–Wallis test. To explore the relationship between the potential risk factors and the severity of symptoms, the Kendall’s tau-b, univariate and multivariate logistic regression analysis were performed. The associations between potential risk factors and outcomes were presented as odds ratios (ORs) and 95% Cis after adjustment for confounders including sex, age, type of hospital, place of residence and the Perceived Stress Scale (PSS) score.

Results

Demographic Characteristics

A total of 966 participants completed this survey. The statistical power was more than 80% (α=0.05) under the assumption of a moderate effect size. Table 1 showed that 33.9% and 66.1% were from Hubei and outside Hubei, respectively. The participants tended to be female (76.4%) and worked in designated hospitals (90.4%).

Table 1

Demographic and Occupational Characteristics of Responders

	Total, No.(%)	Origin of Medical Worker
		Hubei, No.(%)	Outside Hubei, No.(%)
Total	966(100%)	327(33.9%)	639(66.1%)
Hospital
Designated hospital	873(90.4%)	324(37.1%)	549(62.9%)
Shelter hospital	93(9.6%)	3(3.2%)	90(96.8%)
Sex
Man	228(23.6%)	54(23.7%)	174(76.3%)
Woman	738(76.4%)	273(37.0%)	465(63.0%)
Age (years)
8–20	7(0.7%)	4(57.1%)	3(42.9%)
21–40	745(77.1%)	245(32.9%)	500(67.1%)
41–60	214(22.2%)	78(36.4%)	136(63.6%)

Severity of Measurements and Associated Factors

As shown in Table 2, of all participants, medical workers exhibited high prevalence of stress (95.9%), depression (46.0%) and anxiety (39.3%). Local medical workers had higher scores of PSS, PHQ-9, GAD-7 and ASDS than those from outside Hubei (P<0.001). Female medical workers felt more severe perceived stress, depression and anxiety than males (P<0.001). In contrast, there was no significant difference of perceived stress, depression and anxiety between designated and shelter hospitals (P>0. 05).

Table 2

Severity Categories of Stress, Depression, Anxiety and Acute Stress Disorder Measurements in Total Responders and Subgroups

Severity Category	Total, No.(%)	Hospital				Sex				Origin of Medical Worker				Age
		No.(%)				No.(%)				No.(%)
		Designated Hospital	Shelter Hospital	Statistics	P value	Men	Women	Statistics	P value	Hubei	Outside Hubei	Statistics	P value	Statistics	P value
PSS, perceived stress
Normal	40(4.1%)	34(3.9%)	6(6.5%)	39,658.500a	0.605	16(7.0%)	24(3.3%)	74,060.000a	<0.001	5(1.5%)	35(5.5%)	86,770.500a	<0.001	−0.010b	0.692
Mild	162(16.8%)	147(16.8%)	15(16.1%)			52(22.8%)	110(14.9%)			27(8.3%)	135(21.1%)
Moderate/severe	764(79.1%)	692(79.3%)	72(77.4%)			160(70.2%)	604(81.8%)			295(90.2%)	469(73.4%)
PHQ-9, depression
Normal	522(54.0%)	468(53.6%)	54(58.1%)	39,081.000a	0.512	151(66.2%)	371(50.3%)	70,715.500a	<0.001	133(40.7%)	389(60.9%)	81,363.500a	<0.001	−0.024b	0.352
Mild	277(28.7%)	254(29.1%)	23(24.7%)			48(21.1%)	229(31.0%)			112(34.3%)	165(25.8%)
Moderate/severe	167(17.3%)	151(17.3%)	16(17.2%)			29(12.7%)	138(18.7%)			82(25.1%)	85(13.3%)
GAD-7, anxiety
Normal	586(60.7%)	528(60.5%)	58(62.4%)	39,927.000a	0.763	167(73.2%)	419(56.8%)	69,793.500a	<0.001	159(48.6%)	427(66.8%)	83,474.500a	<0.001	0.011b	0.665
Mild	277(28.7%)	252(28.9%)	25(26.9%)			47(20.6%)	230(31.2%)			112(34.3%)	165(25.8%)
Moderate/severe	103(10.7%)	93(10.7%)	10(10.8%)			14(6.1%)	89(12.1%)			56(17.1%)	47(7.4%)
ASDS, acute stress disorder
No	474(94.0%)	424(93.8%)	50(96.2%)	0.136c	0.713	103(95.4%)	371(93.7%)	0.430d	0.512	135(88.8%)	339(96.3%)	10.641d	0.001	−0.015e	0.540
Yes	30(6.0%)	28(6.2%)	2(3.8%)			5(4.6%)	25(6.3%)			17(11.2%)	13(3.7%)

Notes: aMann–Whitney U-test, U. bKendall’s tau-b. cContinuity Correction, c2. dPearson Chi-Square, c2. eBinary logistic regression, B.

Abbreviations: PSS, Perceived Stress Scale; PHQ-9, 9-item Patient Health Questionnaire; GAD-7, 7-item Generalized Anxiety Disorder; ASDS, Acute Stress Disorder Scale.

Scores of Measurements and Associated Factors

The median (IQR) scores on the PSS for stress, the PHQ-9 for depression, the GAD-7 for anxiety, and the ASDS for acute stress disorder for all respondents were 15.0 (11.0–19.0), 4.0 (2.0–8.0), 3.0 (0.0–7.0), and 30.0 (24.0–38.5), respectively. Similar to the findings in severity of symptoms, participants who were local medical workers and female had higher scores of PSS, PHQ-9, GAD-7 and ASDS compared to those who were medical workers from outside Hubei, and male (eg, median [IQR] scores of the measurements among those worked in Hubei vs those worked outside Hubei: PSS, 17.0 [14.0–21.0] vs 14.0 [10.0–17.0], P<0.001; PHQ-9, 6.0 [3.0–9.5] vs 3.0 [1.0–7.0], P<0.001; GAD-7, 5.0 [2.0–8.0] vs 2.0 [0.0–5.0], P<0.001; ASDS, 35.0 [28.0–43.5] vs 28.0 [23.0–17.0], P<0.001; median [IQR] scores of the measurements among men vs women: PSS, 14.0 [9.0–17.0] vs 16.0 [12.0–20.0], P<0.001; PHQ-9, 2.0 [1.0–7.0] vs 4.0 [2.0–8.0], P<0.001; GAD-7, 2.0 [0.0–5.0] vs 4.0 [1.0–7.0], P<0.001; ASDS, 26.5 [22.0–35.0] vs 31.0 [25.0–40.0], P<0.001.). There were no significant differences of perceived stress, depression and anxiety between designated and shelter hospitals (median [IQR] scores of the measurements among designated hospital vs shelter hospitals: PSS, 15.0 [11.0–19.0] vs 14.0 [11.0–18.0], P=0.075; PHQ-9, 4.0 [2.0–8.0] vs 3.0 [1.0–8.0], P=0.267; GAD-7, 3.0 [0.0–6.0] vs 2.0 [0.0–7.0], P=0.61) (Table 3).

Table 3

Scores of Stress, Depression, Anxiety and Acute Stress Disorder

Scale	Total Score, Median(IQR)	Hospital				Sex				Origin of Medical Worker				Age
		Median(IQR)				Median(IQR)				Median(IQR)
		Designated Hospital	Shelter Hospital	Mann–Whitney U	P value	Men	Women	Mann–Whitney U	P value	Hubei	Outside Hubei	Mann–Whitney U	P value	Spearman’s Rho	P value
PSS, perceived stress	15.00	15.00	14.00	36,055.000	0.075	14.00	16.00	66,026.500	<0.001	17.00	14.00	65,529.500	<0.001	−0.039	0.220
	(11.00–19.00)	(11.00–19.00)	(11.00–18.00)			(9.00–17.00)	(12.00–20.00)			(14.00–21.00)	(10.00–17.00)
PHQ-9, depression	4.00	4.00	3.00	37,766.000	0.267	2.00	4.00	65,352.500	<0.001	6.00	3.00	75,462.000	<0.001	−0.036	0.266
	(2.00–8.00)	(2.00–8.00)	(1.00–8.00)			(1.00–7.00)	(2.00–8.00)			(3.00–9.50)	(1.00–7.00)
GAD-7, anxiety	3.00	3.00	2.00	39,317.500	0.613	2.00	4.00	65,936.000	<0.001	5.00	2.00	75,226.500	<0.001	0.010	0.759
	(0.00–7.00)	(0.00–6.00)	(0.00–7.00)			(0.00–5.00)	(1.00–7.00)			(2.00–8.00)	(0.00–5.00)
ASDS, acute stress disorder	30.00	30.00	26.00	9418.500	0.019	26.50	31.00	16,512.000	<0.001	35.00	28.00	18,297.500	<0.001	0.014	0.750
	(24.00–38.50)	(24.00–40.00)	(21.00–34.50)			(22.00–35.00)	(25.00–40.00)			(28.00–43.50)	(23.00–36.00)

Abbreviations: PSS, Perceived Stress Scale; PHQ-9, 9-item Patient Health Questionnaire; GAD-7, 7-item Generalized Anxiety Disorder; ASDS, Acute Stress Disorder Scale.

Risk Factors of Depression and Anxiety

A major purpose of this study was to detect independent risk factors influencing the levels of depression and anxiety in medical workers in Wuhan. Table 4 presented the results of multiple logistic regression models while sequentially adding controls for demographic characteristics, showing that perceived stress is associated with increased odds of depression (OR=1.413; 95% CI: 1.338–1.493; P<0.001) and anxiety (OR=1.515; 95% CI: 1.407–1.631; P<0.001). In this regression model, hospital, sex, age, origin of medical workers and the score of PSS were included, and the backward stepwise logistic regression was applied. A sketch of independent factors influencing the levels of depression and anxiety in medical workers in Wuhan was shown in Figure 1.

Table 4

Risk Factors for Mental Health Outcomes Identified by Multivariable Logistic Regression Analysis

Variables	No. of Moderate or Severe Cases/No. of Total Cases(%)	Adjusted OR(95% CI)a	P value
PHQ-9
PSS	167/966(17.3%)	1.413(1.338–1.493)	<0.001
GAD-7
Hospital
Designated hospital	56/327(17.1%)	1(reference)	NA
Shelter hospital	47/639(7.4%)	2.120(0.952–4.721)	0.066
PSS	103/966(10.7%)	1.515(1.407–1.631)	<0.001

Note: aAdjusted for hospital, sex, age, origin of medical worker and score of PSS.

Abbreviations: PSS, Perceived Stress Scale; PHQ-9, 9-item Patient Health Questionnaire; GAD-7, 7-item Generalized Anxiety Disorder.

Figure 1

Sketch of independent risk factors influencing the levels of depression and anxiety in medical workers in Wuhan. **P<0.01.

Discussion

In this study, we investigated the prevalence of stress, depression, anxiety and acute distress across different medical teams from all of the country working in Wuhan. There are 83.1% and 8.8% of medical workers working in designated and shelter hospitals, respectively. In total, 33.9% of samples are local medical workers from Hubei, and 66.1% originate from other regions in China. Our data demonstrated that front-line medical workers had high prevalence rates of stress, depression and anxiety during the COVID-19 epidemic. This is in line with previous studies,14,19,20 but overall higher than those reported in Singapore.21 When the samples are stratified by the working location, there is no significant difference of stress, depression and anxiety between designated and shelter hospitals. We then detected the differences of mental status in term of origin. Our results showed that local medical workers from Hubei have significantly higher severe stress, depression, anxiety and acute distress than those from other regions.

To the best of our knowledge, this is the first psychological status investigation of medical workers from different regions fighting against COVID-19 in Wuhan. It is a common problem for medical workers to have a psychological response to an epidemic of infectious diseases.22 However, our results showed that local medical workers from Hubei obviously suffered more severe stress, depression, anxiety and acute distress than those from other regions. Since the outbreak of COVID-19 epidemic in Wuhan, local medical workers had to face more and more patients suffering from a known pneumonia caused by the novel coronavirus. Local health care systems were put under tremendous tension by the rapidly rising number of infected cases. As such, the predictable shortage of supplies, fear of being infected, concern about health of self and family, feelings of vulnerability, and being isolated in order not to spread infection at early stage of the epidemic were the sources of distress for the local medical workers from Hubei.23,24 Since the 1st batch of medical teams from outside Hubei arrived in late January 2020, more than 22,000 medical workers fought against COVID-19 together with the local medical workers. Meanwhile, Chinese manufacturers recalled workers from spring festival holiday to plug a shortage of protective suits, masks and other medical supplies. These efforts alleviated the tension on the medical health system as well as the psychological status of medial workers in Wuhan. Therefore, nonlocal medical workers did not experience the duration of acute stress that local ones exposed at early stage of epidemic experienced. This may explain the reason why local medical workers suffered more severe stress, depression, anxiety and acute distress than those from outside Hubei.

Our results showed that gender is another risk factor for the mental status. Female medical workers suffered more severe stress, depression, anxiety and acute distress than males. Most epidemiological studies that have examined the impact of gender on emotion have indicated that females have predisposition for anxiety and depression than males. Its genuine mechanism is still not known, albeit sex role hormones and psychosocial factors are suggested.25 Environmental exposure to COVID-19 may represent a sustained psychosocial stress.26 Stressful events have been long considered relevant triggers for activation of the hypothalamic-pituitary-adrenal (HPA) axis.27 The HPA axis has been implicated in the pathophysiology of a variety of mood disorders, such as depression and anxiety with overactivity of HPA responses.28 HPA axis exhibits a sex-biased activity to control hormonal responses to stress.29 Sex differences in the activation of HPA axis may be influenced by the level of estradiol.30 Therefore, the differences of mental status between male and female medical workers are likely driven by sex hormone in the psychological response to chronic stress caused by COVID-19.

Our multiple logistic regression analysis showed that PSS score is the only independent risk factor for both PHQ-9 and GAD-7 scores. This suggested that high stress level is associated with a higher risk of anxiety and depression. Other factors including working location, origin of medical teams, gender and age did not influence the risk for anxiety and depression in medical workers. We used PSS to scale the level of stress, which requires subjects how often they have found the situations in their unpredictable, uncontrollable, or overwhelming over the past month. Thus, our findings implied that perceivable stress level may play the most important role in the development of anxiety and depression in medical workers. To effectively deal with stress, individuals are naturally equipped with a coping mechanism. However, individuals without the ability to implement positive coping effectively and resolving the stressors may eventually develop psychological health issues.31 As mentioned above, the types of challenges that medical workers faced are similar, such as high risk of being infected, heavy workload and isolated living environment. The differences of coping styles determined the onset or occurrence of anxiety and depression in medical workers in Wuhan. Coping style refers to a cognitive and behavioral strategy used by individuals to overcome, tolerate and offset the internal and external demands of stressful events.32 Then, how to cope with the perceived occupational stress? A Cochrane review has demonstrated that cognitive-behavioral therapy, work-schedule management, mental and physical relaxation could reduce stress to a manageable level.33 Taken together, our results implied that more stress levels the front-line medical workers in Wuhan perceived, more severe levels of anxiety and depression suffered. Self-efficacy has been proven to influence the individual choices of behavioral activities, effort expenditure and persistence when facing obstacle and task performance.34 A growing body of studies most recently has focused on the mediation effect of self-efficacy between stress and physical and psychological outcomes. Studies investigating the relationship between perceived stress and self-efficacy found that high level of perceived stress is associated with low levels of self-efficacy.35 Furthermore, several studies indicated that high level of perceived stress predicted low levels of self-efficacy. Therefore, timely psychological support including availing counseling services, informal or formal supervision and establishing peer support systems are helpful to improve self-efficacy and required to take measures to decrease the stress levels and encourage medical workers to adopt their coping styles.36 Recently, we have investigated the psychological impacts and depression in the nonmedical staff in Wuhan. Our findings suggested that nonmedical staff on the front-line of COVID-19 outbreak also had high rates of symptoms of depression. The female gender, younger age, and increased stress reactions were associated with the increased risk for depression.37 As such, psychological inventions are required for both the medical workers and nonmedical staff.38

This study has several limitations that should be taken into account. First, this is a cross-sectional survey and it is difficult to exhibit the systematic changes of psychological status of medical workers in Wuhan. Second, we used self-rating scales to evaluate stress, anxiety, depression and PTSD. Compared with clinical interviews, self-rating can be a source of bias, with risks of false and over judgment. Third, we did not evaluate the duration of the exposition to the stressful condition when significant differences in multiple outcomes were found between local and nonlocal medical workers. As such, our present findings should be interpreted with caution, and future studies on this subject are suggested to employ a mixed-methods design to explore specific themes and intervention strategies.

In conclusion, our results demonstrated a high prevalence of stress, depression, anxiety and acute distress among medical workers during COVID-19 outbreak in Wuhan. The level of psychological impact may be mediated by individual perceptions of stressful events. Therefore, personalized psychological care from psychotherapists and psychiatrists would benefit the medical workers to decrease the stress levels and adopt their coping styles.