Mohammad Moniruzzaman1,2, Aya Kadota1,2, Hiroyoshi Segawa1, Keiko Kondo2, Sayuki Torii2, Naoko Miyagawa3, Akira Fujiyoshi4, Takashi Hisamatsu5, Yoshiyuki Watanabe6, Akihiko Shiino7, Kazuhiko Nozaki8, Hirotsugu Ueshima1,2, Katsuyuki Miura1,2. 1. Center for Epidemiologic Research in Asia (M.M., A.K., H.S., H.U., K.M.), Shiga University of Medical Science, Otsu, Japan. 2. Department of Public Health (M.M., A.K., K.K., S.T., H.U., K.M.), Shiga University of Medical Science, Otsu, Japan. 3. International Center for Nutrition and Information, National Institute of Health and Nutrition, Shinjuku-ku, Tokyo, Japan (N.M.). 4. Department of Hygiene, School of Medicine, Wakayama Medical University, Japan (A.F.). 5. Department of Public Health, Okayama University, Japan (T.H.). 6. Department of Radiology (Y.W.), Shiga University of Medical Science, Otsu, Japan. 7. Molecular Neuroscience Research Center (A.S.), Shiga University of Medical Science, Otsu, Japan. 8. Department of Neurosurgery (K.N.), Shiga University of Medical Science, Otsu, Japan.
Abstract
BACKGROUND AND PURPOSE: Cerebral small vessel disease (CSVD) is a common subclinical feature of the aging brain. Steps per day may contribute to its prevention. We herein investigated the association between step counts and CSVD in a healthy Japanese male population. METHODS: We analyzed data from 680 men who were free of stroke and participated in this observational study. Seven-day step counts were assessed at baseline (2006-2008) using a pedometer. CSVD was assessed at follow-ups (2012-2015) based on deep and subcortical white matter hyperintensities (WMHs), periventricular hyperintensities, lacunar infarcts, and cerebral microbleeds on magnetic resonance imaging. Using a logistic regression analysis, we computed the adjusted odds ratios, with 95% CIs, of prevalent CSVD according to quartiles of step counts (reference: Q1). We also investigated the association between step counts and WMH volumes using a quantile regression. RESULTS: Steps per day were significantly associated with lower odds ratios, with the lowest at Q3 (8175-10 614 steps/day), of higher (versus low or no burden) deep and subcortical WMHs (odds ratio, 0.52 [95% CI, 0.30-0.89]), periventricular hyperintensities (0.50 [95% CI, 0.29-0.86]), and lacunar infarcts (0.52 [95% CI, 0.30-0.91]) compared with Q1 (≤6060 steps/day) but not cerebral microbleeds. An inverse linear association was observed between step counts and WMH volumes. These associations were independent of age and smoking and drinking status and remained consistent when adjusted for vascular risk factors. CONCLUSIONS: We found a J-shaped relationship between step counts and prevalent CSVD in healthy Japanese men, with the lowest risk being observed among participants with ≈8000 to 10 000 steps/day. Higher steps were also associated with lower WMH volumes.
BACKGROUND AND PURPOSE:Cerebral small vessel disease (CSVD) is a common subclinical feature of the aging brain. Steps per day may contribute to its prevention. We herein investigated the association between step counts and CSVD in a healthy Japanese male population. METHODS: We analyzed data from 680 men who were free of stroke and participated in this observational study. Seven-day step counts were assessed at baseline (2006-2008) using a pedometer. CSVD was assessed at follow-ups (2012-2015) based on deep and subcortical white matter hyperintensities (WMHs), periventricular hyperintensities, lacunar infarcts, and cerebral microbleeds on magnetic resonance imaging. Using a logistic regression analysis, we computed the adjusted odds ratios, with 95% CIs, of prevalent CSVD according to quartiles of step counts (reference: Q1). We also investigated the association between step counts and WMH volumes using a quantile regression. RESULTS: Steps per day were significantly associated with lower odds ratios, with the lowest at Q3 (8175-10 614 steps/day), of higher (versus low or no burden) deep and subcortical WMHs (odds ratio, 0.52 [95% CI, 0.30-0.89]), periventricular hyperintensities (0.50 [95% CI, 0.29-0.86]), and lacunar infarcts (0.52 [95% CI, 0.30-0.91]) compared with Q1 (≤6060 steps/day) but not cerebral microbleeds. An inverse linear association was observed between step counts and WMH volumes. These associations were independent of age and smoking and drinking status and remained consistent when adjusted for vascular risk factors. CONCLUSIONS: We found a J-shaped relationship between step counts and prevalent CSVD in healthy Japanese men, with the lowest risk being observed among participants with ≈8000 to 10 000 steps/day. Higher steps were also associated with lower WMH volumes.
Entities:
Keywords:
aging brain diseases; cerebral small vessel diseases; exercise; white matter hyperintensities
Authors: Adrian Wong; Bonnie Yin Ka Lam; Margaret Kit Yi Mak; Linda Chiu Wa Lam; Lisa Wing Chi Au; Brian Ka Fung Yiu; Chun Wong; Hor Yee Tong; Sin Ki Yeung; Winnie Chiu Wing Chu; Lin Shi; Thomas Wai Hong Leung; Yannie Oi Yan Soo; Alexander Yuk Lun Lau; Bonaventure Yiu Ming Ip; Timothy Chi Yui Kwok; Ho Ko; Vincent Chung Tong Mok Journal: Alzheimers Dement (N Y) Date: 2021-12-31