Aikaterini Mastoraki1, Dimitrios Schizas2, Eleni Papoutsi2, Vasiliki Ntella2, Prodromos Kanavidis2, Athanasios Sioulas3, Marina Tsoli4, Georgios Charalampopoulos5, Michail Vailas2, Evangelos Felekouras2. 1. First Department of Surgery, National and Kapodistrian University of Athens, Laikon General Hospital, Athens, Greece dr_kamast@yahoo.gr. 2. First Department of Surgery, National and Kapodistrian University of Athens, Laikon General Hospital, Athens, Greece. 3. Department of Gastroenterology, Hygeia Hospital, Athens, Greece. 4. First Department of Internal Medicine, National and Kapodistrian University of Athens, Laikon General Hospital, Athens, Greece. 5. Department of Radiology, Laikon General Hospital, Athens, Greece.
Abstract
BACKGROUND/AIM: Somatostatinomas (SSomas) constitute a rare neuroendocrine tumor. The purpose of this study was to evaluate the current published literature about pancreatic SSomas and report epidemiologic and clinicopathologic data for this entity. PATIENTS AND METHODS: A combined automated and manual systematic database search of the literature was performed using electronic search engines (Medline PubMed, Scopus, Ovid and Cochrane Library), until February 2020. Statistical analysis was performed using the R language and environment for statistical computing. RESULTS: Overall, the research revealed a total of 36 pancreatic SSoma cases. Patient mean age was 50.25 years. The most common pancreatic location was the pancreatic head (61.8%). The most frequent clinical symptom was abdominal pain (61.1%). Diagnostic algorithm most often included Computed Tomography and biopsy; surgical resection was performed in 28 cases. Out of the 36 cases, 22 had been diagnosed with a metastatic tumor and metastasectomy was performed in 6 patients with a worse overall survival (OS) (p=0.029). In total, OS was 47.74 months. CONCLUSION: Patients with metastatic disease did not benefit from metastasectomy, but the sample size was small to reach definite conclusions. However, further studies with longer follow-up are needed for a better evaluation of these results. Copyright
BACKGROUND/AIM: Somatostatinomas (SSomas) constitute a rare neuroendocrine tumor. The purpose of this study was to evaluate the current published literature about pancreatic SSomas and report epidemiologic and clinicopathologic data for this entity. PATIENTS AND METHODS: A combined automated and manual systematic database search of the literature was performed using electronic search engines (Medline PubMed, Scopus, Ovid and Cochrane Library), until February 2020. Statistical analysis was performed using the R language and environment for statistical computing. RESULTS: Overall, the research revealed a total of 36 pancreatic SSoma cases. Patient mean age was 50.25 years. The most common pancreatic location was the pancreatic head (61.8%). The most frequent clinical symptom was abdominal pain (61.1%). Diagnostic algorithm most often included Computed Tomography and biopsy; surgical resection was performed in 28 cases. Out of the 36 cases, 22 had been diagnosed with a metastatic tumor and metastasectomy was performed in 6 patients with a worse overall survival (OS) (p=0.029). In total, OS was 47.74 months. CONCLUSION:Patients with metastatic disease did not benefit from metastasectomy, but the sample size was small to reach definite conclusions. However, further studies with longer follow-up are needed for a better evaluation of these results. Copyright
Authors: O P Ganda; G C Weir; J S Soeldner; M A Legg; W L Chick; Y C Patel; A M Ebeid; K H Gabbay; S Reichlin Journal: N Engl J Med Date: 1977-04-28 Impact factor: 91.245
Authors: C Nakanome; M Koizumi; H Fujiya; H Akai; T Toyota; Y Goto; J Kameyama; K Miyakawa; K Hanew Journal: Tohoku J Exp Med Date: 1984-02 Impact factor: 1.848