Hiroaki Miyake1, Koji Murono2, Kazushige Kawai2, Hiroaki Nozawa2, Harufumi Maki3, Kiyoshi Hasegawa3, Jun Nakajima4, Soichiro Ishihara2. 1. Department of Surgical Oncology, The University of Tokyo, Tokyo, Japan MIYAKEH-SUR@h.u-tokyo.ac.jp. 2. Department of Surgical Oncology, The University of Tokyo, Tokyo, Japan. 3. Hepato-Biliary-Pancreatic Surgery Division, Artificial Organ and Transplantation Division, Department of Surgery, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan. 4. Department of Thoracic Surgery, The University of Tokyo, Tokyo, Japan.
Abstract
BACKGROUND/AIM: We aimed to elucidate the prognostic impact of tumor doubling time (DT) and radical surgery when classified by DT in patients with metachronous liver, lung, or peritoneal metastases of colorectal cancer (CRC). PATIENTS AND METHODS: We reviewed the data of 1941 patients who underwent curative surgery for CRC and calculated DT for recurrences using computed tomography. RESULTS: Short DT was an independent prognostic risk factor in liver (p<0.001) and peritoneal (p=0.03) metastases. Survival was significantly better in patients who underwent surgery than in those who did not, both in short and long DT groups in any metastatic organ (p<0.01). Patients with long DT gained significantly better prognostic benefit from surgery than those with short DT in liver (p=0.01) and peritoneal (p=0.04) metastases. CONCLUSION: Surgery is recommended for resectable metastases, especially in patients with liver and peritoneal metastases with long DT. Copyright
BACKGROUND/AIM: We aimed to elucidate the prognostic impact of tumor doubling time (DT) and radical surgery when classified by DT in patients with metachronous liver, lung, or peritoneal metastases of colorectal cancer (CRC). PATIENTS AND METHODS: We reviewed the data of 1941 patients who underwent curative surgery for CRC and calculated DT for recurrences using computed tomography. RESULTS: Short DT was an independent prognostic risk factor in liver (p<0.001) and peritoneal (p=0.03) metastases. Survival was significantly better in patients who underwent surgery than in those who did not, both in short and long DT groups in any metastatic organ (p<0.01). Patients with long DT gained significantly better prognostic benefit from surgery than those with short DT in liver (p=0.01) and peritoneal (p=0.04) metastases. CONCLUSION: Surgery is recommended for resectable metastases, especially in patients with liver and peritoneal metastases with long DT. Copyright
Authors: Rebecca A Snyder; Chung-Yuan Hu; Amanda Cuddy; Amanda B Francescatti; Jessica R Schumacher; Katherine Van Loon; Y Nancy You; Benjamin D Kozower; Caprice C Greenberg; Deborah Schrag; Alan Venook; Daniel McKellar; David P Winchester; George J Chang Journal: JAMA Date: 2018-05-22 Impact factor: 56.272
Authors: K Nomura; S Miyagawa; H Harada; H Kitamura; H Seki; R Shimada; A Kobayashi; T Noike; S Kawasaki Journal: Dig Surg Date: 1998 Impact factor: 2.588
Authors: John N Primrose; Rafael Perera; Alastair Gray; Peter Rose; Alice Fuller; Andrea Corkhill; Steve George; David Mant Journal: JAMA Date: 2014-01-15 Impact factor: 56.272