Diana Costa1, Rita Ferreira1, Justina Prada2,3, Felisbina Luisa Queiroga4,5,6, Paula Rodrigues2,3, Filipe Silva2,3, Isabel Pires2,3. 1. Department of Genetics and Biotechnology, University of Trás-os-Montes and Alto Douro, Vila Real, Portugal. 2. Department of Veterinary Sciences, University of Trás-os-Montes and Alto Douro, Vila Real, Portugal. 3. Animal and Veterinary Research Centre (CECAV), University of Trás-os-Montes and Alto Douro, Vila Real, Portugal. 4. Department of Veterinary Sciences, University of Trás-os-Montes and Alto Douro, Vila Real, Portugal fqueirog@utad.pt. 5. Center for Research and Technology of Agro-Environment and Biological Sciences (CITAB), University of Trás-os-Montes and Alto Douro, Vila Real, Portugal. 6. Center for the Study of Animal Sciences, CECA-ICETA, University of Porto, Porto, Portugal.
Abstract
BACKGROUND/AIM: Canine Cutaneous Histiocytoma (CCH) is a Langerhans' cells benign tumour that undergoes spontaneous regression. The aim of the present study was to investigate the role of angiogenesis, a key step for tumour development, in CCH regression. MATERIALS AND METHODS: 50 CCH samples were classified into 4 histological groups according to a regression scale, and evaluated for expression of vascular endothelial factor-A (VEGF-A) and its receptor VEGFR-2 as well as microvessel density (MVD). RESULTS: Tumours during early stages of the regressive process had a lower MVD compared to later stages, while CCH tumoural cells showed a limited production of VEGF, but higher levels of VEGFR-2. On the contrary, tumours in advanced phases of regression showed a higher number of neovessels, probably associated with the inflammatory state and the healing process. CONCLUSION: Our results suggest that angiogenesis may be compromised at early stages of histiocytoma development and this may be a determinant of regression in this tumour. Copyright
BACKGROUND/AIM: CanineCutaneous Histiocytoma (CCH) is a Langerhans' cells benign tumour that undergoes spontaneous regression. The aim of the present study was to investigate the role of angiogenesis, a key step for tumour development, in CCH regression. MATERIALS AND METHODS: 50 CCH samples were classified into 4 histological groups according to a regression scale, and evaluated for expression of vascular endothelial factor-A (VEGF-A) and its receptor VEGFR-2 as well as microvessel density (MVD). RESULTS:Tumours during early stages of the regressive process had a lower MVD compared to later stages, while CCH tumoural cells showed a limited production of VEGF, but higher levels of VEGFR-2. On the contrary, tumours in advanced phases of regression showed a higher number of neovessels, probably associated with the inflammatory state and the healing process. CONCLUSION: Our results suggest that angiogenesis may be compromised at early stages of histiocytoma development and this may be a determinant of regression in this tumour. Copyright
Authors: Isabel Pires; Paula Rodrigues; Anabela Alves; Felisbina Luisa Queiroga; Filipe Silva; Carlos Lopes Journal: In Vivo Date: 2013 Mar-Apr Impact factor: 2.155
Authors: Simone de Brot; Atara Ntekim; Ryan Cardenas; Victoria James; Cinzia Allegrucci; David M Heery; David O Bates; Niels Ødum; Jenny L Persson; Nigel P Mongan Journal: Endocr Relat Cancer Date: 2015-04-13 Impact factor: 5.678