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Literature DB >> 3314368

The intraneoplastic chemotherapy in a rat brain tumour model utilizing methotrexate-polymethylmethacrylate-pellets.

B Rama¹, T Mandel, J Jansen, E Dingeldein, H D Mennel.

Abstract

In an experimental glioma model, using ethylnitrosourea induced and subsequently intracerebrally implanted tumours in BD-IX rats, the effectiveness of intratumoural application of methotrexate (MTX) by stereotactic implantation of polymethylmethacrylate (PMMA) pellets containing MTX, has been studied. Tumour volume 10 days after pellet implantation as well as survival rates of treated, untreated and control animals have been the criteria of the effect of treatment. Tumour volume was significantly smaller in treated compared to untreated animals. The survival rate of untreated to treated animals increased 150 and 233% respectively when compared with the control animals. Thus a positive therapeutic effect of MTX-PMMA pellet implantation in the experimental glioma could be proven. Possible consequences for the treatment of human gliomas are shortly discussed.

Entities: Chemical Disease Species

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Year: 1987 PMID： 3314368 DOI： 10.1007/BF02076020

Source DB: PubMed Journal: Acta Neurochir (Wien) ISSN： 0001-6268 Impact factor: 2.216

41 in total

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Authors: T S Vats; R A Morantz; G W Wood; S Tilzer
Journal: Int J Radiat Oncol Biol Phys Date: 1979-09 Impact factor: 7.038

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Authors: R Ringkjob
Journal: Acta Neurol Scand Date: 1968 Impact factor: 3.209

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Journal: Int Surg Date: 1969-02

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Journal: Arch Neurol Date: 1975-12

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Authors: H D Mennel; D Hellwig; H Simon
Journal: J Cancer Res Clin Oncol Date: 1986 Impact factor: 4.553

6. Improved treatment of a brain-tumor model. Part 2: Sequential therapy with BCNU and 5-fluorouracil.

Authors: M A Gerosa; D V Dougherty; C B Wilson; M L Rosenblum
Journal: J Neurosurg Date: 1983-03 Impact factor: 5.115

7. Therapy of an experimental glioma with systemic or intraneoplastic methotrexate or radiation.

Authors: C H Tator; W Wassenaar; A Day; W S So
Journal: J Neurosurg Date: 1977-02 Impact factor: 5.115

8. Regional blood flow and capillary permeability in the ethylnitrosourea-induced rat glioma.

Authors: K Yamada; T Hayakawa; Y Ushio; N Arita; A Kato; H Mogami
Journal: J Neurosurg Date: 1981-12 Impact factor: 5.115

9. Current brain tumour models with particular consideration of the transplantation techniques. Outline of literature and personal preliminary results.

Authors: B Rama; O Spoerri; M Holzgraefe; H D Mennel
Journal: Acta Neurochir (Wien) Date: 1986 Impact factor: 2.216