S Sauer-Delhées1, F Steffen1, I Reichler2, K Beckmann1. 1. Klinik für Kleintierchirurgie, Abteilung Neurologie, Vetsuisse-Fakultät, Universität Zürich. 2. Klinik für Reproduktionsmedizin, Vetsuisse-Fakultät, Universität Zürich.
Abstract
INTRODUCTION: Background: Little is known about idiopathic Epilepsy in Greater Swiss Mountain Dogs. Until now this breed is not listed as a predisposed breed for idiopathic epilepsy. The aim of this study was to estimate the prevalence of idiopathic epilepsy in Greater Swiss Mountain Dogs in Switzerland and to describe the clinical characteristics of epilepsy in this breed including seizures semiology and response to treatment. Material and Methods: Records of the Swiss Kennel Club for Greater Swiss Mountain Dogs were searched for reported cases of epileptic seizures between 1999-2019. The total number of reported cases and the signalment was reviewed. Furthermore, all owners of Greater Swiss Mountain Dogs registered to the breeding club were invited to complete an online questionnaire. Results: In total 600 Greater Swiss Mountain Dog's live in Switzerland: 70-90 puppies are born each year. Between 1999 and 2019 34 dogs (2%) were announced with seizures. Of the 400 owners invited to answer the questionnaire 128 completed the questionnaire. 20 of these 128 dogs were suffering from idiopathic epilepsy. The prevalence for idiopathic epilepsy based on the questionnaire was therefore 15,6%. All affected dogs showed generalized tonic-clonic seizures. Cluster seizures and status epilepticus occurred in 5 (41,6%) and 6 (50%) of the dogs. Long term seizure control was only achieved in 10% of the dogs. Five dogs (25%) died or were euthanized because of insufficient seizure control. Only one dog (5%) showed clinical remission. Conclusion: Prevalence of idiopathic epilepsy is higher in Greater Swiss Mountain Dogs in Switzerland compared to the general dog population. Seizure control seems to be difficult to achieve in this breed and remission-rate is low.
INTRODUCTION: Background: Little is known about idiopathic Epilepsy in Greater Swiss Mountain Dogs. Until now this breed is not listed as a predisposed breed for idiopathic epilepsy. The aim of this study was to estimate the prevalence of idiopathic epilepsy in Greater Swiss Mountain Dogs in Switzerland and to describe the clinical characteristics of epilepsy in this breed including seizures semiology and response to treatment. Material and Methods: Records of the Swiss Kennel Club for Greater Swiss Mountain Dogs were searched for reported cases of epileptic seizures between 1999-2019. The total number of reported cases and the signalment was reviewed. Furthermore, all owners of Greater Swiss Mountain Dogs registered to the breeding club were invited to complete an online questionnaire. Results: In total 600 Greater Swiss Mountain Dog's live in Switzerland: 70-90 puppies are born each year. Between 1999 and 2019 34 dogs (2%) were announced with seizures. Of the 400 owners invited to answer the questionnaire 128 completed the questionnaire. 20 of these 128 dogs were suffering from idiopathic epilepsy. The prevalence for idiopathic epilepsy based on the questionnaire was therefore 15,6%. All affected dogs showed generalized tonic-clonic seizures. Cluster seizures and status epilepticus occurred in 5 (41,6%) and 6 (50%) of the dogs. Long term seizure control was only achieved in 10% of the dogs. Five dogs (25%) died or were euthanized because of insufficient seizure control. Only one dog (5%) showed clinical remission. Conclusion: Prevalence of idiopathic epilepsy is higher in Greater Swiss Mountain Dogs in Switzerland compared to the general dog population. Seizure control seems to be difficult to achieve in this breed and remission-rate is low.
Entities:
Keywords:
Anfallscharakteristik; Grand Bouvier Suisse; Greater Swiss Mountain Dog; Grosser Schweizer Sennenhund; Idiopathische Epilepsie; Rasseprädisposition; Remissionsrate; breed predisposition; caractéristiques de crise; caratteristiche delle crisi epilettiche; epilessia idiopatica; grande bovaro svizzero; idiopathic epilepsy; predisposizione della razza; prédisposition raciale; remission rate; seizure semiology; tasso di remissione; taux de rémission; épilepsie idiopathique
Authors: Katrin M Beckmann; Adriano Wang-Leandro; Henning Richter; Rima N Bektas; Frank Steffen; Matthias Dennler; Ines Carrera; Sven Haller Journal: Sci Rep Date: 2021-12-13 Impact factor: 4.379
Authors: Theresa Elisabeth Ostermann; Jasmin Nicole Nessler; Hildegard Urankar; Norbert Bachmann; Christel Fechler; Andrea Bathen-Nöthen; Andrea Tipold Journal: Front Vet Sci Date: 2022-07-12