| Literature DB >> 33140204 |
Yu-Yang Li1,2, Qing Cai1, Bao-Sheng Li1, Shu-Wei Qiao1,2, Jia-Yang Jiang1,2, Dan Wang1,2, Xue-Chun Du1,2, Wei-Yan Meng3.
Abstract
Periodontitis is a chronic inflammatory disease induced by Porphyromonas gingivalis (P. gingivalis) and other pathogens. P. gingivalis release various virulence factors including lipopolysaccharide (LPS). However, whether P. gingivalis-LPS inducing pyroptosis in human gingival fibroblasts (HGFs) remains unknown. In present study, P. gingivalis-LPS decreased the membrane integrity of HGFs, and pyroptosis-associated cytokines were upregulated at the mRNA level. In addition, pyroptosis proteins were highly expressed in gingival tissues of periodontitis. P. gingivalis-LPS induced gingivitis in the rat model, and the expression level of pyroptosis-associated proteins increased. Together, P. gingivalis-LPS can activate the pyroptosis reaction, which may be a pro-pyroptosis status in a relative low concentration.Entities:
Keywords: Porphyromonas gingivalis; fibroblast; lipopolysaccharide; programmed cell death; pyroptosis
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Year: 2020 PMID： 33140204 DOI： 10.1007/s10753-020-01379-7
Source DB: PubMed Journal: Inflammation ISSN： 0360-3997 Impact factor: 4.092