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Literature DB >> 33139286

Effect of a Neuropilin-1-Derived Virus Receptor Trap on Enterovirus A71 Infection In Vitro.

Hsiang-Ching Wang^1,2, Peng-Nien Huang^3,4, Hui-Chen Hung⁵, Sung-Nien Tseng³, Chia-Chia Chang⁶, Ya-Ru Tsai⁵, Yun-Ming Wang⁷, Shin-Ru Shih^3,8, John Tsu-An Hsu^9,5.

Abstract

We discovered that neuropilin 1 (NRP1) is a new receptor candidate to mediate enterovirus A71 (EVA71) into cells. In the engineered form as a decoy receptor, NRP1 was able to recognize and neutralize EVA71 but not enterovirus D68 or coxsackievirus B3 (CVB3). NRP1 recognizes EVA71 through a novel domain on the VP3 capsid protein. The principle in the design, engineering, and refinement of the NRP1-based decoy receptor described in this study represents a general and well-suited antiviral strategy.

Entities: Disease Gene Species

Keywords: antiviral research; decoy receptor; enterovirus A71; neuropilin 1; virus receptor trap

Year: 2020 PMID： 33139286 PMCID： PMC7927848 DOI： 10.1128/AAC.00695-20

Source DB: PubMed Journal: Antimicrob Agents Chemother ISSN： 0066-4804 Impact factor: 5.191

26 in total

1. Biopharmaceutical benchmarks 2018.

Authors: Gary Walsh
Journal: Nat Biotechnol Date: 2018-12-06 Impact factor: 54.908

2. Transgenic mouse model for the study of enterovirus 71 neuropathogenesis.

Authors: Ken Fujii; Noriyo Nagata; Yuko Sato; Kien Chai Ong; Kum Thong Wong; Seiya Yamayoshi; Midori Shimanuki; Hiroshi Shitara; Choji Taya; Satoshi Koike
Journal: Proc Natl Acad Sci U S A Date: 2013-08-19 Impact factor: 11.205

3. Identification and characterization of a cross-neutralization epitope of Enterovirus 71.

Authors: Chia-Chyi Liu; Ai-Hsiang Chou; Shu-Pei Lien; Hsiao-Yu Lin; Shih-Jen Liu; Jui-Yuan Chang; Meng-Shin Guo; Yen-Hung Chow; Wun-Syue Yang; Kate Hsuen-Wen Chang; Charles Sia; Pele Chong
Journal: Vaccine Date: 2011-04-16 Impact factor: 3.641

4. Cell surface nucleolin facilitates enterovirus 71 binding and infection.

Authors: Pei-Yi Su; Ya-Fang Wang; Sheng-Wen Huang; Yu-Chih Lo; Ya-Hui Wang; Shang-Rung Wu; Dar-Bin Shieh; Shun-Hua Chen; Jen-Ren Wang; Ming-Der Lai; Chuan-Fa Chang
Journal: J Virol Date: 2015-02-11 Impact factor: 5.103

5. Enterovirus 71 uses cell surface heparan sulfate glycosaminoglycan as an attachment receptor.

Authors: Chee Wah Tan; Chit Laa Poh; I-Ching Sam; Yoke Fun Chan
Journal: J Virol Date: 2012-10-24 Impact factor: 5.103

6. Structural studies of neuropilin/antibody complexes provide insights into semaphorin and VEGF binding.

Authors: Brent A Appleton; Ping Wu; Janice Maloney; JianPing Yin; Wei-Ching Liang; Scott Stawicki; Kyle Mortara; Krista K Bowman; J Michael Elliott; William Desmarais; J Fernando Bazan; Anil Bagri; Marc Tessier-Lavigne; Alexander W Koch; Yan Wu; Ryan J Watts; Christian Wiesmann
Journal: EMBO J Date: 2007-11-08 Impact factor: 11.598

7. Antiviral Activity of a Llama-Derived Single-Domain Antibody against Enterovirus A71.

Authors: Peng-Nien Huang; Hsiang-Ching Wang; Hui-Chen Hung; Sung-Nien Tseng; Teng-Yuan Chang; Min-Yuan Chou; Yu-Jen Chen; Yun-Ming Wang; Shin-Ru Shih; John Tsu-An Hsu
Journal: Antimicrob Agents Chemother Date: 2020-04-21 Impact factor: 5.191

8. Neuropilin 1 is an entry factor that promotes EBV infection of nasopharyngeal epithelial cells.

Authors: Hong-Bo Wang; Hua Zhang; Jing-Ping Zhang; Yan Li; Bo Zhao; Guo-Kai Feng; Yong Du; Dan Xiong; Qian Zhong; Wan-Li Liu; Huamao Du; Man-Zhi Li; Wen-Lin Huang; Sai Wah Tsao; Lindsey Hutt-Fletcher; Yi-Xin Zeng; Elliott Kieff; Mu-Sheng Zeng
Journal: Nat Commun Date: 2015-02-11 Impact factor: 14.919

Effect of a Neuropilin-1-Derived Virus Receptor Trap on Enterovirus A71 Infection In Vitro.

1. Biopharmaceutical benchmarks 2018.

2. Transgenic mouse model for the study of enterovirus 71 neuropathogenesis.

3. Identification and characterization of a cross-neutralization epitope of Enterovirus 71.

4. Cell surface nucleolin facilitates enterovirus 71 binding and infection.

5. Enterovirus 71 uses cell surface heparan sulfate glycosaminoglycan as an attachment receptor.

6. Structural studies of neuropilin/antibody complexes provide insights into semaphorin and VEGF binding.

7. Antiviral Activity of a Llama-Derived Single-Domain Antibody against Enterovirus A71.

8. Neuropilin 1 is an entry factor that promotes EBV infection of nasopharyngeal epithelial cells.

9. Sialylated glycans as receptor and inhibitor of enterovirus 71 infection to DLD-1 intestinal cells.

Review 10. Immunocompetent and Immunodeficient Mouse Models for Enterovirus 71 Pathogenesis and Therapy.

1. External evaluation of published population pharmacokinetic models of polymyxin B.

Review 2. Neuropilin (NRPs) Related Pathological Conditions and Their Modulators.

Review 3. Role of Neuropilin 1 in COVID-19 Patients with Acute Ischemic Stroke.