Literature DB >> 33139277

Impact of Intraoperative Cell Salvage on Concentrations of Antibiotics Used for Surgical Prophylaxis.

Maxwell J Lasko1, Allison M Conelius2, Oscar K Serrano3,4, David P Nicolau1,5, Joseph L Kuti6.   

Abstract

Intraoperative cell salvage (IOCS) is used to administer autologous blood lost during surgery. We studied antibiotic disposition through an ex vivo IOCS system for vancomycin, piperacillin, ampicillin, and cefazolin. Only 2% ± 1% of antibiotic inoculated in whole blood was recovered in the IOCS reinfusion bag, whereas 97% ± 17% was found in the waste. These observations were confirmed for ampicillin in two patients undergoing liver transplantation. Studies measuring the impact of IOCS on perioperative antibiotic concentrations are warranted.
Copyright © 2020 American Society for Microbiology.

Entities:  

Keywords:  cell salvage; pharmacokinetics; prophylaxis

Year:  2020        PMID： 33139277      PMCID： PMC7674051          DOI： 10.1128/AAC.01725-20

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  13 in total

Review 1.  Cell salvage for minimising perioperative allogeneic blood transfusion.

Authors:  Paul A Carless; David A Henry; Annette J Moxey; Dianne O'Connell; Tamara Brown; Dean A Fergusson
Journal:  Cochrane Database Syst Rev       Date:  2010-04-14

2.  Therapeutic drug monitoring of beta-lactams for critically ill patients: unwarranted or essential?

Authors:  Jason A Roberts; William W Hope; Jeffrey Lipman
Journal:  Int J Antimicrob Agents       Date:  2010-03-01       Impact factor: 5.283

3.  In vitro blood culture bottle inoculation of whole blood with clinically relevant antibiotic concentrations: a word of caution.

Authors:  M Grupper; J L Kuti; D P Nicolau
Journal:  Eur J Clin Microbiol Infect Dis       Date:  2016-12-28       Impact factor: 3.267

Review 4.  Perioperative autotransfusion and its correlation to hemostasis and coagulopathies.

Authors:  P Page
Journal:  J Extra Corpor Technol       Date:  1991

5.  Clinical pharmacokinetics and safety of high doses of ceforanide (BL-S786R) and cefazolin.

Authors:  R D Smyth; M Pfeffer; A Glick; D R Van Harken; G H Hottendorf
Journal:  Antimicrob Agents Chemother       Date:  1979-11       Impact factor: 5.191

6.  Comparative penetration of cefonicid and cefazolin into the atrial appendage and pericardial fluid of patients undergoing open-heart surgery.

Authors:  M N Dudley; C H Nightingale; A D Drezner; H B Low; R Quintiliani
Journal:  Antimicrob Agents Chemother       Date:  1984-09       Impact factor: 5.191

Review 7.  Autologous blood salvage in the era of patient blood management.

Authors:  R A Sikorski; N A Rizkalla; W W Yang; S M Frank
Journal:  Vox Sang       Date:  2017-06-05       Impact factor: 2.144

Review 8.  Pharmacokinetic/pharmacodynamic parameters: rationale for antibacterial dosing of mice and men.

Authors:  W A Craig
Journal:  Clin Infect Dis       Date:  1998-01       Impact factor: 9.079

9.  Bactericidal activity of low-dose ceftizoxime plus metronidazole compared with cefoxitin and ampicillin-sulbactam.

Authors:  C D Freeman; C H Nightingale; D P Nicolau; P P Belliveau; P R Tessier; Q Fu; D W Xuan; R Quintiliani
Journal:  Pharmacotherapy       Date:  1994 Mar-Apr       Impact factor: 4.705

10.  Potentially clinically relevant concentrations of Cefazolin, Midazolam, Propofol, and Sufentanil in auto-transfused blood in congenital cardiac surgery.

Authors:  Gerda A Zeilmaker-Roest; Annewil van Saet; Joost van Rosmalen; Soma Bahmany; Antony van Dijk; Enno D Wildschut; Dick Tibboel; Ad J J C Bogers
Journal:  J Cardiothorac Surg       Date:  2018-06-08       Impact factor: 1.637
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  1 in total

1.  Cell Saver Blood Reinfusion Up to 24 Hours Post Collection in Pediatric Cardiac Surgical Patients Does Not Increase Incidence of Hospital-Acquired Infections or Mortality.

Authors:  Laura Boulos; Joseph D Kuebler; Ron Angona; Dawn Sweeney; Hongyue Wang; Elizabeth Nocera; Jill M Cholette
Journal:  J Extra Corpor Technol       Date:  2021-09
  1 in total

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