Tsunehiko Maruyama1, Mitsugi Shimoda2, Hiroyuki Hakoda3, Akihiro Sako3, Kazumitsu Ueda4, Shuji Suzuki2. 1. Department of Surgery, Mito Saiseikai General Hospital, Japan; Department of Gastroenterological Surgery, Ibaraki Medical Center, Tokyo Medical University, Japan. Electronic address: t-maru@ya2.so-net.ne.jp. 2. Department of Gastroenterological Surgery, Ibaraki Medical Center, Tokyo Medical University, Japan. 3. Department of Surgery, Hitachi General Hospital, Japan. 4. Department of Gastroenterological Surgery, Tsukuba Memorial Hospital, Japan.
Abstract
BACKGROUND: Preoperative nutritional and inflammatory indices have been reported to be associated with the prognosis of patients with malignancy. We evaluated clinicopathological factors, including nutritional and inflammatory indices, and recurrence prognosis in patients with stage IIA colon cancer (CC) who underwent curative surgery. METHODS: This retrospective study included 197 patients with stage IIA CC who had undergone curative resection. We evaluated the association between prognostic nutritional index (PNI), neutrophil-lymphocyte ratio (NLR), and platelet-lymphocyte ratio (PLR) with clinicopathological factors and prognosis for recurrence. For the recurrence-free survival (RFS) analysis, receiver operating characteristic (ROC) curves were used to determine appropriate cutoff values for PNI, NLR, and PLR. RESULTS: Univariate analyses showed that PNI<44.8 (P = 0.028) was significantly associated with worse RFS in patients with stage IIA CC patients. In the multivariate analyses, PNI<44.8 (hazard ratio [HR] 2.082; 95% confidence interval [CI] 1.005-4.317; P = 0.049) independently and significantly predicted RFS. CONCLUSION: PNI is a useful marker for predicting recurrence prognosis in post-resection patients with stage IIA CC.
BACKGROUND: Preoperative nutritional and inflammatory indices have been reported to be associated with the prognosis of patients with malignancy. We evaluated clinicopathological factors, including nutritional and inflammatory indices, and recurrence prognosis in patients with stage IIA colon cancer (CC) who underwent curative surgery. METHODS: This retrospective study included 197 patients with stage IIA CC who had undergone curative resection. We evaluated the association between prognostic nutritional index (PNI), neutrophil-lymphocyte ratio (NLR), and platelet-lymphocyte ratio (PLR) with clinicopathological factors and prognosis for recurrence. For the recurrence-free survival (RFS) analysis, receiver operating characteristic (ROC) curves were used to determine appropriate cutoff values for PNI, NLR, and PLR. RESULTS: Univariate analyses showed that PNI<44.8 (P = 0.028) was significantly associated with worse RFS in patients with stage IIA CC patients. In the multivariate analyses, PNI<44.8 (hazard ratio [HR] 2.082; 95% confidence interval [CI] 1.005-4.317; P = 0.049) independently and significantly predicted RFS. CONCLUSION: PNI is a useful marker for predicting recurrence prognosis in post-resection patients with stage IIA CC.
Authors: Hye Seon Kang; Ah Young Shin; Chang Dong Yeo; Sung Kyoung Kim; Chan Kwon Park; Ju Sang Kim; Seung Joon Kim; Sang Haak Lee; Jin Woo Kim Journal: In Vivo Date: 2021 Nov-Dec Impact factor: 2.155