Erik A Holzwanger1, Mohammad Bilal2, Jeremy R Glissen Brown2, Shailendra Singh3, Aymeric Becq4, Kenneth Ernest-Suarez5, Tyler M Berzin2. 1. Division of Gastroenterology and Hepatology, Tufts Medical Center, Boston, Massachusetts, United States. 2. Center for Advanced Endoscopy, Division of Gastroenterology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, United States. 3. West Virginia University Health Sciences Center Charleston Division, Charleston, West Virginia, United States. 4. Sorbonne Université, Centre d'Endoscopie Digestive, Hôpital Saint Antoine, APHP, Paris, France. 5. Gastroenterology Department, Hospital México, University of Costa Rica, San Jose, Costa Rica.
Abstract
BACKGROUND: The occurrence of false-positive alerts is an important outcome measure in computer-aided colon polyp detection (CADe) studies. However, there is no consensus definition of a false positive in clinical trials evaluating CADe in colonoscopy. We aimed to study the diagnostic performance of CADe based on different threshold definitions for false-positive alerts. METHODS: A previously validated CADe system was applied to screening/surveillance colonoscopy videos. Different thresholds for false-positive alerts were defined based on the time an alert box was continuously traced by the system. Primary outcomes were false-positive results and specificity using different threshold definitions of false positive. RESULTS: 62 colonoscopies were analyzed. CADe specificity and accuracy were 93.2 % and 97.8 %, respectively, for a threshold definition of ≥ 0.5 seconds, 98.6 % and 99.5 % for a threshold definition of ≥ 1 second, and 99.8 % and 99.9 % for a threshold definition of ≥ 2 seconds. CONCLUSION: Our analysis demonstrated how different threshold definitions of false positive can impact the reported diagnostic performance of CADe for colon polyp detection. Thieme. All rights reserved.
BACKGROUND: The occurrence of false-positive alerts is an important outcome measure in computer-aided colon polyp detection (CADe) studies. However, there is no consensus definition of a false positive in clinical trials evaluating CADe in colonoscopy. We aimed to study the diagnostic performance of CADe based on different threshold definitions for false-positive alerts. METHODS: A previously validated CADe system was applied to screening/surveillance colonoscopy videos. Different thresholds for false-positive alerts were defined based on the time an alert box was continuously traced by the system. Primary outcomes were false-positive results and specificity using different threshold definitions of false positive. RESULTS: 62 colonoscopies were analyzed. CADe specificity and accuracy were 93.2 % and 97.8 %, respectively, for a threshold definition of ≥ 0.5 seconds, 98.6 % and 99.5 % for a threshold definition of ≥ 1 second, and 99.8 % and 99.9 % for a threshold definition of ≥ 2 seconds. CONCLUSION: Our analysis demonstrated how different threshold definitions of false positive can impact the reported diagnostic performance of CADe for colon polyp detection. Thieme. All rights reserved.
Authors: Markus Brand; Joel Troya; Adrian Krenzer; Zita Saßmannshausen; Wolfram G Zoller; Alexander Meining; Thomas J Lux; Alexander Hann Journal: United European Gastroenterol J Date: 2022-05-05 Impact factor: 6.866