| Literature DB >> 33137677 |
Alla Mitrofanova1, Antonio M Fontanella2, Sandra Merscher2, Alessia Fornoni3.
Abstract
A critical link between metabolic disorders and a form of low-grade systemic and chronic inflammation has been recently established and named 'Metaflammation'. Metaflammation has been recognized as a key mediator of both microvascular and macrovascular complications of diabetes and as a significant contributor to the development of diabetic kidney disease (DKD). The goal of this review is to summarize the contribution of diabetes-induced inflammation and the related signaling pathways to diabetic complications, with a particular focus on how innate immunity and lipid metabolism influence each other.Entities:
Year: 2020 PMID: 33137677 PMCID: PMC7769904 DOI: 10.1016/j.coph.2020.09.004
Source DB: PubMed Journal: Curr Opin Pharmacol ISSN: 1471-4892 Impact factor: 5.547