Mauro Mato1,2, Allegra Franchino1,2, Cristina Garcı A-Morales1,2, Antonio M Echavarren1,2. 1. Institute of Chemical Research of Catalonia (ICIQ), Barcelona Institute of Science and Technology, Av. Països Catalans 16, 43007 Tarragona, Spain. 2. Departament de Quı́mica Analı́tica i Quı́mica Orgànica, Universitat Rovira i Virgili, C/Marcel·li Domingo s/n, 43007 Tarragona, Spain.
Abstract
Three- and four-membered rings, widespread motifs in nature and medicinal chemistry, have fascinated chemists ever since their discovery. However, due to energetic considerations, small rings are often difficult to assemble. In this regard, homogeneous gold catalysis has emerged as a powerful tool to construct these highly strained carbocycles. This review aims to provide a comprehensive summary of all the major advances and discoveries made in the gold-catalyzed synthesis of cyclopropanes, cyclopropenes, cyclobutanes, cyclobutenes, and their corresponding heterocyclic or heterosubstituted analogs.
Three- class="Chemical">and four-membered rings, widesclass="Chemical">pread motifs in nature class="Chemical">pan class="Chemical">and medicinal chemistry, have fascinated chemists ever since their discovery. However, due to energetic considerations, small rings are often difficult to assemble. In this regard, homogeneous gold catalysis has emerged as a powerful tool to construct these highly strained carbocycles. This review aims to provide a comprehensive summary of all the major advances and discoveries made in the gold-catalyzed synthesis of cyclopropanes, cyclopropenes, cyclobutanes, cyclobutenes, and their corresponding heterocyclic or heterosubstituted analogs.
Authors: Zeng Rong Wong; Tim K Schramm; Matthias Loipersberger; Martin Head-Gordon; F Dean Toste Journal: Angew Chem Int Ed Engl Date: 2022-03-30 Impact factor: 16.823