Chunyan Hu1,2, Yi Zhang1,2, Jie Zhang1,2, Yanan Huo3, Qin Wan4, Mian Li1,2, Hongyan Qi1,2, Rui Du1,2, Yuanyue Zhu1,2, Yingfen Qin5, Ruying Hu6, Lixin Shi7, Qing Su8, Xuefeng Yu9, Li Yan10, Guijun Qin11, Xulei Tang12, Gang Chen13, Min Xu1,2, Tiange Wang1,2, Zhiyun Zhao1,2, Yuhong Chen1,2, Zhengnan Gao14, Guixia Wang15, Feixia Shen16, Zuojie Luo5, Li Chen17, Qiang Li18, Zhen Ye6, Yinfei Zhang19, Chao Liu20, Youmin Wang21, Shengli Wu22, Tao Yang23, Huacong Deng24, Lulu Chen25, Jiajun Zhao26, Yiming Mu27, Weiqing Wang1,2, Yu Xu1,2, Yufang Bi1,2, Jieli Lu1,2, Guang Ning1,2. 1. Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. 2. Shanghai National Clinical Research Center for Metabolic Diseases, Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the PR China, Shanghai National Center for Translational Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. 3. Jiangxi Provincial People's Hospital Affiliated to Nanchang University, Nanchang, China. 4. The Affiliated Hospital of Luzhou Medical College, Luzhou, China. 5. The First Affiliated Hospital of Guangxi Medical University, Nanning, China. 6. Zhejiang Provincial Center for Disease Control and Prevention, Hangzhou, China. 7. Affiliated Hospital of Guiyang Medical College, Guiyang, China. 8. Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai, China. 9. Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. 10. Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China. 11. The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China. 12. The First Hospital of Lanzhou University, Lanzhou, China. 13. Fujian Provincial Hospital, Fujian Medical University, Fuzhou, China. 14. Dalian Municipal Central Hospital, Dalian, China. 15. The First Hospital of Jilin University, Changchun, China. 16. The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China. 17. Qilu Hospital of Shandong University, Jinan, China. 18. The Second Affiliated Hospital of Harbin Medical University, Harbin, China. 19. Central Hospital of Shanghai Jiading District, Shanghai, China. 20. Jiangsu Province Hospital on Integration of Chinese and Western Medicine, Nanjing, China. 21. The First Affiliated Hospital of Anhui Medical University, Hefei, China. 22. Karamay Municipal People's Hospital, Xinjiang, China. 23. The First Affiliated Hospital of Nanjing Medical University, Nanjing, China. 24. The First Affiliated Hospital of Chongqing Medical University, Chongqing, China. 25. Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. 26. Shandong Provincial Hospital affiliated to Shandong University, Jinan, China. 27. Chinese People's Liberation Army General Hospital, Beijing, China.
Abstract
BACKGROUND: Age at menarche was reported to be associated with the risk of diabetes. However, the impact of ideal cardiovascular health metrics (ICVHMs) on the association between age at menarche and adulthood diabetes risk was unclear. METHODS: We included 121 431 women from the nationwide, population-based cohort of the REACTION study (Risk Evaluation of Cancers in Chinese Diabetic Individuals: a Longitudinal Study). The diagnosis of diabetes was based on the oral glucose tolerance test (OGTT) and glycosylated hemoglobin (HbA1c) measurement. Logistic regression and multiplicative interaction analysis were conducted to investigate the potential interaction effect between age at menarche and ICVHMs on the development of diabetes. RESULTS: The multivariable-adjusted odds ratios of diabetes across categories of age at menarche (<14, 14-17, and > 17 years) were 1.22 (95% confidence interval [CI]: 1.17, 1.28), 1.00 (reference), and 0.89 (95% CI: 0.85, 0.93), respectively. In subgroup analysis, significant interactions were detected between total cholesterol/blood pressure levels and age at menarche regarding the risk of diabetes (P for interaction = .0091 and .0019, respectively). The increased risk associated with age at menarche <14 years was observed in participants with three or fewer ICVHMs, but not in women with four or more ICVHMs (P for interaction = .0001). CONCLUSIONS: Age at menarche was inversely associated with the risk of diabetes in adulthood in Chinese women, and it appeared to be modified by the presence of ICVHMs. Further studies are needed to clarify the precise interrelationship and the generalizability of our results.
BACKGROUND: Age at menarche was reported to be associated with the risk of diabetes. However, the impact of ideal cardiovascular health metrics (ICVHMs) on the association between age at menarche and adulthood diabetes risk was unclear. METHODS: We included 121 431 women from the nationwide, population-based cohort of the REACTION study (Risk Evaluation of Cancers in Chinese Diabetic Individuals: a Longitudinal Study). The diagnosis of diabetes was based on the oral glucose tolerance test (OGTT) and glycosylated hemoglobin (HbA1c) measurement. Logistic regression and multiplicative interaction analysis were conducted to investigate the potential interaction effect between age at menarche and ICVHMs on the development of diabetes. RESULTS: The multivariable-adjusted odds ratios of diabetes across categories of age at menarche (<14, 14-17, and > 17 years) were 1.22 (95% confidence interval [CI]: 1.17, 1.28), 1.00 (reference), and 0.89 (95% CI: 0.85, 0.93), respectively. In subgroup analysis, significant interactions were detected between total cholesterol/blood pressure levels and age at menarche regarding the risk of diabetes (P for interaction = .0091 and .0019, respectively). The increased risk associated with age at menarche <14 years was observed in participants with three or fewer ICVHMs, but not in women with four or more ICVHMs (P for interaction = .0001). CONCLUSIONS: Age at menarche was inversely associated with the risk of diabetes in adulthood in Chinese women, and it appeared to be modified by the presence of ICVHMs. Further studies are needed to clarify the precise interrelationship and the generalizability of our results.
Authors: Zorimar Rivera-Núñez; Carolyn W Kinkade; Yingting Zhang; Amber Rockson; Elisa V Bandera; Adana A M Llanos; Emily S Barrett Journal: Curr Environ Health Rep Date: 2022-07-22